Herpesvirus causing self-limiting infection in immunocompetent individuals, but with potentially severe consequences in immuno-suppressed transplant patients.
Individual at risk
Guidance at RECRUITMENT
Guidance at CT
CMV IgG should be performed at CT to ascertain donor CMV serostatus.
Guidance at WORK-UP
CMV-IgG and IgM should be performed at work-up. If CMV IgM is postitive, CMV-PCR should be undertaken.
Testing outcomes and guidance
CMV-IgM = negative, CMV-IgG = positive or negative
CMV-IgM = positive, CMV-IgG = positive, CMV-PCR negative
Status information should be reported to the transplant centre
The donor can be cleared at workup.
If there is a change of CMV status from CT to work-up stage, the transplant centre should be informed immediately.
CMV-IgG weak positive results should be referred to reference lab for confirmation
CMV-IgM = positive and CMV-IgG = negative and CMV-PCR=negative
Results should be referred to reference lab for confirmation
CMV-PCR = positive
Donor cannot be cleared. Inform transplant centre and discuss donor deferral
Justification for guidance
CMV can cause devastating complications in post-transplant recipients. Accurate donor CMV serostatus plays an important role in donor selection.
Pergam SA, Xie H, Sandhu R, et al. Efficiency and Risk Factors for CMV Transmission in Seronegative Hematopoietic Stem Cell Recipients. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012;18(9):1391-1400. doi:10.1016/j.bbmt.2012.02.008. 
Pseudonyms or Related Conditions
Version 2, Edition 1
Date of Last Update
9 June 2016