Haemoglobin Disorder

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Acceptability at Recruitment


Acceptability at CT / Work-Up


Individual at Risk


Explanation of Condition

Covers a wide variety of inhertied disorders of haemoglobin, of which the most common will be thalassaemia and sickle cell disease.


Discuss with MO and inform transplant centre.


Thalassaemia major or intermedia

Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD)

High affinity haemoglobin

Other clinically significant structural or functional haemoglobinopathies.

If mother or father homozygous or heterozygous for inherited haemoglobin disorders and infant affected

Acceptable if haemoglobin is within normal sex-adjusted range

Alpha or beta thalassaemia trait

Sickle cell trait

HbC, HbDPunjab/Oman, HbE traits

Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait.

There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only.

Pseudonyms or Related Conditions


Version 1, Edition 2

Date of Last Update

1 June 2016