Heart, Congenital Defect
Acceptability at Recruitment
Acceptability at CT / Work-Up
Individual at Risk
Explanation of Condition
This covers a wide range of heart abnormalities that are, by definition, present from birth. The most common defects are simple 'hole-in-the-heart' abnormalities, such as an atrial septal defect (ASD), patent foramen ovale (PFO) or ventricular septal defect (VSD).
Apheresis and bone marrow harvest may increase the risk of small clots passing across such a defect in the heart and into the circulation of the brain, leading to a stroke. With a normal heart, these clots would be harmlessly filtered out by the lungs. In addition, there is a theoretical risk of infection in the heart (endocarditis), particularly if a central venous catheter is inserted.
Many people with congenital heart disease or with previous heart surgery take long-term antibiotics to prevent endocarditis. However, the evidence to support this use is weak, and there is no evidence to support their use in people with simple congenital defects such as an atrial or ventricular septal defect. As a result, this should not be used as a criteria to accept or decline a donor.
In addition, the latest NICE (National Institute of Clinical Evidence) guidance suggests that there is no increased risk of infectious endocarditis is those with a simple atrial septal defect, or surgically corrected ASD, VSD or PDA following invasive procedures.
Surgically corrected simple defect (ASD, VSD, PFO), or uncorrected small asymptomatic ventricular septal defect.
Surgically corrected PDA provided no further symptoms or related cardiac problems. Discuss with cardiac team if still under follow-up
Uncorrected atrial septal defect (ASD) or patent foramen ovale (PFO)
Large ventricular septal defect (VSD)
Any complex congenital defect, such as Tetralogy of Fallot (TOF), Transposition of the Great Arteries (TGA), Anomalous pulmonary circulation.
See also Heart, Valve Disease
Discuss each case with medical officer.
Pseudonyms or Related Conditions
Ventricular septal defect (VSD)
Atrial septal defect (ASD)
Patent foramen ovale (PFO)
Tetralogy of Fallot
Hole in the heart
Patent ductus arteriosus (PDA)
Transposition of the great vessels
Anomolous pulmonary venous return
Version 1, Edition 2
Date of Last Update
1 June 2016