Hormone Replacement Therapy

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Acceptability at Recruitment


Acceptability at CT / Work-Up


Individual at Risk


Explanation of Condition

Many conditions require hormone replacement. Today, most hormones are recreated synthetically in laboratories, and thus have negligible risk of carrying infectious organisms. However, some are still derived from human or animal tissue.

Those derived from human pituitary tissue are no longer used, but people who received them before variant CJD was identified are at risk of having contracted the disease, and thus must not donate.

There is considerable debate about the risk of hormones derived from human urine (usually HCG from pregnant women), but this risk is thought to be extremely small.


Unacceptable if derived from human pituitary tissue. Pituitary derived hormones have not been used in the UK since 1985

Acceptable if entirely synthetic or recombinant hormone used.

If derived from human urine, accept at recruitment and inform transplant centre at CT. Urinary hormones used in fertility treatment are Menopur and Merional HP


What condition hormone treatment was used to treat

When and in which country hormone treatment was given

If for IVF name of drug used

Discuss individual cases with MO if required.

Pseudonyms or Related Conditions

Fertility treatment


Growth Hormone


Version 1, Edition 2

Date of Last Update

9 August 2016