Difference between revisions of "Autoimmune diseases and G-CSF"
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Acceptability at Recruitment[edit] | Acceptability at Recruitment[edit] | ||
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QUALIFIED - see below | QUALIFIED - see below | ||
Acceptability at CT / Work-Up[edit] | Acceptability at CT / Work-Up[edit] | ||
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QUALIFIED - see below | QUALIFIED - see below | ||
Individual at Risk[edit] | Individual at Risk[edit] | ||
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Donor / Recipient | Donor / Recipient | ||
Explanation of Condition[edit] | Explanation of Condition[edit] | ||
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Autoimmune diseases can be potentially triggered by G-CSF. Also, there is a theoretical risk of transmission of the disease to the recipient. | Autoimmune diseases can be potentially triggered by G-CSF. Also, there is a theoretical risk of transmission of the disease to the recipient. | ||
Guidance[edit] | Guidance[edit] | ||
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GCSF should be [[avoided]] in the following situations: | GCSF should be [[avoided]] in the following situations: | ||
1. Multisystem autoimmune disorders such as rheumatoid arthritis | 1. Multisystem autoimmune disorders such as rheumatoid arthritis | ||
Revision as of 12:02, 13 December 2017
Acceptability at Recruitment[edit]
QUALIFIED - see below
Acceptability at CT / Work-Up[edit]
QUALIFIED - see below
Individual at Risk[edit]
Donor / Recipient
Explanation of Condition[edit]
Autoimmune diseases can be potentially triggered by G-CSF. Also, there is a theoretical risk of transmission of the disease to the recipient.
Guidance[edit]
GCSF should be avoided in the following situations: 1. Multisystem autoimmune disorders such as rheumatoid arthritis 2. Single system autoimmune disorders that involve vital organ such as kidney (IgA nephropathy), eye (iritis) or the CNS (MS included) 3. Single system autoimmune disease which is still active or was particularly severe.
In all these situations the donor must be informed and counselled. Regarding Graves Disease, recent Graves disease cannot go ahead but older cases of Graves disease may be accepted
- If in doubt, discuss with Medical Officer. - Inform the transplant centre.
