Autoimmune diseases and G-CSF

From Anthony Nolan Medical Guidelines
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Acceptability at Recruitment[edit] QUALIFIED - see below

Acceptability at CT / Work-Up[edit] QUALIFIED - see below

Individual at Risk[edit] Donor / Recipient

Explanation of Condition[edit] Autoimmune diseases can be potentially triggered by G-CSF. Also, there is a theoretical risk of transmission of the disease to the recipient.

Guidance[edit] GCSF should be avoided in the following situations: 1. Multisystem autoimmune disorders such as rheumatoid arthritis 2. Single system autoimmune disorders that involve vital organ such as kidney (IgA nephropathy), eye (iritis) or the CNS (MS included) 3. Single system autoimmune disease which is still active or was particularly severe.

In all these situations the donor must be informed and counselled. Regarding Graves Disease, recent Graves disease cannot go ahead but older cases of Graves disease may be accepted

- If in doubt, discuss with Medical Officer. - Inform the transplant centre.

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