Difference between revisions of "Haemoglobin Disorder"
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===Unacceptable=== | ===Unacceptable=== | ||
Thalassaemia major or intermedia | Thalassaemia major or intermedia | ||
| + | |||
Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD) | Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD) | ||
| + | |||
High affinity haemoglobin | High affinity haemoglobin | ||
| + | |||
Other clinically significant structural or functional haemoglobinopathies. | Other clinically significant structural or functional haemoglobinopathies. | ||
===Acceptable if haemoglobin is within normal sex-adjusted range=== | ===Acceptable if haemoglobin is within normal sex-adjusted range=== | ||
Alpha or beta thalassaemia trait | Alpha or beta thalassaemia trait | ||
| + | |||
Sickle cell trait | Sickle cell trait | ||
| + | |||
HbC, HbDPunjab/Oman, HbE traits | HbC, HbDPunjab/Oman, HbE traits | ||
| + | |||
Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait. | Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait. | ||
Revision as of 07:31, 13 June 2012
Contents
Acceptability at Recruitment
QUALIFIED
Acceptability at CT / Work-Up
QUALIFIED
Individual at Risk
Recipient
Explanation of Condition
Covers a wide variety of inhertied disorders of haemoglobin, of which the most common will be thalassaemia and sickle cell disease.
Guidance
Discuss with MO and inform transplant centre.
Unacceptable
Thalassaemia major or intermedia
Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD)
High affinity haemoglobin
Other clinically significant structural or functional haemoglobinopathies.
Acceptable if haemoglobin is within normal sex-adjusted range
Alpha or beta thalassaemia trait
Sickle cell trait
HbC, HbDPunjab/Oman, HbE traits
Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait.
There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only.
Pseudonyms or Related Conditions
Version
Version 1, Edition 1
Date of Last Update
15th June 2012
