Hepatitis B

From Anthony Nolan Medical Guidelines
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Acceptability at Recruitment

QUALIFIED

Acceptability at CT / Work-Up

QUALIFIED

Individual at Risk

Recipient

Explanation of Condition

Viral liver infection transmitted through contact with blood or other body fluids, most commonly transmitted through sex, from mother to child, or through contaminated blood products or needles.

Guidance

Discuss each case with medical officer.

Current Infection

Unacceptable if current active infection (HbSAg positive or HBV DNA positive).

Infected Current Sexual Partner

Acceptable if evidence of past resolved infection or immunity from vaccination:

Donor is hep B surface antibody positive and hep B surface antigen negative

Core Ab antibody may also be positive if resolved infection

HepB PCR negative (performed at medical)

Past Infection

May donate if:

More than 12 months from recovery of acute infection

All serological antigen markers (HBSAntigen, HBeAntigen) are negative, HB core antibody is positive and anti-HBs antibody is positive.

PCR test (performed at medical) should be negative.

Inform TC as soon as past infection identified

Former Sexual Partner

A former sexual partner of an infected individual may donate from four months after last sexual contact if either:

All serological markers are negative

OR

positive HB core antibody, positive Hep B surface antibody and all antigen markers negative.


Inform transplant centre of all potential exposures.

Four month deferral may be shortened at discretion of transplant centre

Pseudonyms or Related Conditions

Version

Version 1, Edition 2

Date of Last Update

1 June 2016