Difference between revisions of "Inherited Blood Disorder, family history of"

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====Date of Last Update====
 
====Date of Last Update====
15th June 2012
+
21st August 2013

Revision as of 11:15, 21 August 2013

Acceptability at Recruitment

QUALIFIED

Acceptability at CT / Work-Up

QUALIFIED

Individual at Risk

Recipient

Explanation of Condition

Inherited disorders of blood production include such disorders as Haemoglobin Disorders, G6PD Deficiency Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital diserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.

Guidance

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known.

At recruitment

May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

At CT/Work-up

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.


See also specific guidance for Diamond-Blackfan Syndrome, family history of

Version

Version 1, Edition 1

Date of Last Update

21st August 2013