Difference between revisions of "PrEP"

From Anthony Nolan Medical Guidelines
Jump to navigation Jump to search
 
(11 intermediate revisions by 3 users not shown)
Line 3: Line 3:
  
 
==Acceptability at Recruitment==
 
==Acceptability at Recruitment==
−
ACCEPTABLE but inform donors that they should be off PrEP for 3 months before VT
+
Acceptable
  
 
==Acceptability at CT / Work-Up==
 
==Acceptability at CT / Work-Up==
−
Acceptable if donor has been off PrEP for at least 3 months + low sexual risk behaviour.  
+
Acceptable if the donor has not taken PrEP for at least 3 months + there is low sexual risk behaviour. Please discuss with the MO team.
  
 
Otherwise postpone.
 
Otherwise postpone.
Line 14: Line 14:
  
 
==Explanation of Condition==
 
==Explanation of Condition==
−
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).
+
Pre-Exposure Prophylaxis (PrEP) is used to prevent HIV infection  
  
 
==Justification for guidance==
 
==Justification for guidance==
−
Similar to High Risk Sexual Behaviour:
+
PrEP may alter HIV testing, resulting in an unclear or negative result in HIV positive donors, with a potential risk of transmission of this virus to patients.  
−
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.
 
  
−
In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.
+
We care a lot about the health of our donors. If you've been using medications like PrEP or PEP to prevent HIV, it could affect the accuracy of HIV tests for up to 3 months after you stop using them (Seed et al, 2020 - [https://espace.library.uq.edu.au/data/UQ_25f1211/UQ25f1211_OA.pdf?Expires=1700906000&Key-Pair-Id=APKAJKNBJ4MJBJNC6NLQ&Signature=RUtNkW7DAeNiYuVCx7khuVhmRY91jP7jWN7OuPW-G6zerKmiY24GmaaZjqR9b5E3aNimH~Hbx8rDtzJt43UFOUe7~C468BE13pofA72j8eox0QT1W7ceXk8itpALlSHUv~wYYXVw2YyzQcKX9G-8dbdLEwg41bGpE7YfG-0Sc0XHT38w64uG9mGdK4-JUt3Kby6MeIgykqqxH74n-~yVoIFmoe81pJtUKidEfZZdiXELpXsb80Aymx-HxZc2vPveVBybbpBy40Lxknt0o9w9t9QyjZgv~zLcz2hdmyx4IWAQBS6~UhtzFYZl~CB~c6-CWcYHHxWI8F42~-xRyvuYMg__]). Because of this, health authorities worldwide, including the UK, advise that if you've used PrEP or PEP in the last 3 months, you shouldn't donate.

Latest revision as of 13:05, 30 November 2023

PrEP – Pre-Exposure Prophylaxis


Acceptability at Recruitment

Acceptable

Acceptability at CT / Work-Up

Acceptable if the donor has not taken PrEP for at least 3 months + there is low sexual risk behaviour. Please discuss with the MO team.

Otherwise postpone.

Individual at Risk

Recipient

Explanation of Condition

Pre-Exposure Prophylaxis (PrEP) is used to prevent HIV infection

Justification for guidance

PrEP may alter HIV testing, resulting in an unclear or negative result in HIV positive donors, with a potential risk of transmission of this virus to patients.

We care a lot about the health of our donors. If you've been using medications like PrEP or PEP to prevent HIV, it could affect the accuracy of HIV tests for up to 3 months after you stop using them (Seed et al, 2020 - [1]). Because of this, health authorities worldwide, including the UK, advise that if you've used PrEP or PEP in the last 3 months, you shouldn't donate.

Retrieved from "https://www.med-guidelines.org.uk/index.php?title=PrEP&oldid=1853"