PrEP

From Anthony Nolan Medical Guidelines
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PrEP – Pre-Exposure Prophylaxis


Acceptability at Recruitment

ACCEPTABLE but inform donors that they should be off PrEP for 3 months before VT

Acceptability at CT / Work-Up

Acceptable if donor has been off PrEP for at least 3 months + low sexual risk behaviour.

Otherwise postpone.

Individual at Risk

Recipient

Explanation of Condition

Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

Justification for guidance

Similar to High Risk Sexual Behaviour: With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.