Anthony Nolan Medical Guidelines - User contributions [en]

West Nile Virus

2013-08-21T14:39:52Z

Dr Robert Lown: /* Explanation of Condition */

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Infection causing fever and, rarely, encephalitis (brain inflammation). It is transmitted by a mosquito bite in endemic areas.

WNV is endemic throughout North America and certain regions of Europe. For the latest European epidemiology see [http://www.ecdc.europa.eu/en/healthtopics/west_nile_fever/West-Nile-fever-maps/Pages/index.aspx European Centre for Disease Prevention and Control]

See also [http://en.wikipedia.org/wiki/West_Nile_virus West Nile Virus]

==Guidance==
Discuss with medical officer.

====Unacceptable====
Diagnosed with, or had a febrile illness consistent with, West Nile Virus less than six months ago;

Less than four weeks since returning from an area in which WNV is thought to be endemic, if WNV NAT (nucleic acid test) testing is unavailable;

====Acceptable====
More than 6 months has passed since the resolution of symptoms from a confirmed or suspected infection;

More than 4 weeks from return from an endemic area if the donor has shown no symptoms of infection;

Less than 4 weeks from return from an endemic area if the donor has shown no symptoms of infection, and a validated WNV NAT is negative

For the most up to date advice on areas with endemic WNV, refer to the [http://www.transfusionguidelines.org.uk/index.aspx?Publication=GDRI&Section=66 Geographical Disease Risk Index]

==Pseudonyms or Related Conditions==
WNV

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Inherited Blood Disorder, first degree relative with

2013-08-21T11:53:30Z

Dr Robert Lown: /* Autosomal dominant/X-linked */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as Fanconi syndrome, Diamond-Blackfan syndrome, Schwachman-Diamond syndrome and congenital dyserythropoietic anaemia. Please see separate guidance for [[Haemoglobin Disorder]]s and [[G6PD Deficiency]].

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, including mode of inheritance as well as the underlying mutation, if known.

===At recruitment===

====Autosomal dominant/X-linked====
May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

====Autosomal recessive====
May join the register if clinically asymptomatic

===At CT/Work-up===

====Autosomal dominant/X-linked====

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation, and has a normal full blood count.

The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

====Autosomal recessive====
May proceed at the discretion of the requesting transplant centre

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
21st August 2013

Inherited Blood Disorder, first degree relative with

2013-08-21T11:49:07Z

Dr Robert Lown: /* Explanation of Condition */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as Fanconi syndrome, Diamond-Blackfan syndrome, Schwachman-Diamond syndrome and congenital dyserythropoietic anaemia. Please see separate guidance for [[Haemoglobin Disorder]]s and [[G6PD Deficiency]].

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, including mode of inheritance as well as the underlying mutation, if known.

===At recruitment===

====Autosomal dominant/X-linked====
May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

====Autosomal recessive====
May join the register if clinically asymptomatic

===At CT/Work-up===

====Autosomal dominant/X-linked====

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

====Autosomal recessive====
May proceed at the discretion of the requesting transplant centre

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
21st August 2013

Diamond-Blackfan Syndrome, family history of

2013-08-21T11:36:07Z

Dr Robert Lown:

The following guidance was received from Dr Adrianna Vlachos (Head, Bone Marrow Failure Program, Steven and Alexandra Cohen Children's Medical Center of New York Hematology/Oncology and Stem Cell Transplantation Feinstein Institute for Medical Research):

Dear Dr. Lown

These are very interesting questions. We know that DBA is found to be inherited as an autosomal dominant in ~45% of RPS19 cases, with parents and other family members often showing mild or no signs of anemia. This was published years ago by Dr. Orfali and Dr. Ball from the UK DBA data.

All of the RPS and RPL mutations known to date are wither auto dominant or new sporadic mutations. Gata1 is inherited as X-linked.

We do recommend that persons with an affected family member be screened with a CBC and erythrocyte ADA activity, and take particular interest if there are family members with congenital anomalies. If a genetic mutation is found in the proband then we do offer genetic testing on the immediate family members.

There was an abstract years ago of a child (age 10) who was a donor for her younger brother with DBA. She was clinically well. Unfortunately the BM did not engraft and 3 years later, at her puberty, the donor presented with anemia and was found to have an elevated eADA.

Having said this, your questions pose an interesting discussion. We of course would not screen the general population for any of these autosomal dominant disorders in a standard way. However if the donor had an affected child and a mutation was known on that child then she should be screened for the same mutation, even if her CBC and eADA were normal. We identify family members all the time in our screening that have the mutation and are "silent" at this time. We don't know what they will do in the future - as we have had patients present as adults. Most importantly, we believe that this bone marrow would probably not engraft well into the patient.

If the mother is negative for the mutation her child has, then there is a small chance of gonadal mosaicism but this would not affect her being a BM donor.

If she was positive I would not count her as a BM donor.

If there is no gene identified then the CBC and eADA could be used as screening tools. If no anemia, macrocytosis or elevated eADA then the accepting physician could make the call about using the donor, especially if this was the only one for that patient.

Inherited Blood Disorder, first degree relative with

2013-08-21T11:35:04Z

Dr Robert Lown: Page created

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as Diamond-Blackfan syndrome, Schwachman-Diamond syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome. Please see separate guidance for [[Haemoglobin Disorder]]s and [[G6PD Deficiency]].

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, including mode of inheritance as well as the underlying mutation, if known.

===At recruitment===

====Autosomal dominant/X-linked====
May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

====Autosomal recessive====
May join the register if clinically asymptomatic

===At CT/Work-up===

====Autosomal dominant/X-linked====

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

====Autosomal recessive====
May proceed at the discretion of the requesting transplant centre

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
21st August 2013

Main Page

2013-08-21T11:34:53Z

Dr Robert Lown: /* I */

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

'''02/05/14. Guidance updated:''' [[Retinoic Acid Derivatives]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, see [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Blood Disorder, first degree relative with]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Inherited Blood Disorder, family history of

2013-08-21T11:20:54Z

Dr Robert Lown: /* Explanation of Condition */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known.

===At recruitment===

May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

===At CT/Work-up===

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
21st August 2013

Inherited Blood Disorder, family history of

2013-08-21T11:19:40Z

Dr Robert Lown: /* Explanation of Condition */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known.

===At recruitment===

May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

===At CT/Work-up===

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
21st August 2013

Diamond-Blackfan Syndrome, family history of

2013-08-21T11:18:52Z

Dr Robert Lown: PAge created

The following guidance was received from Dr Adrianna Vlachos, who specialises in Diamond-Blackfan Syndrome:

Dear Dr. Lown

These are very interesting questions. We know that DBA is found to be inherited as an autosomal dominant in ~45% of RPS19 cases, with parents and other family members often showing mild or no signs of anemia. This was published years ago by Dr. Orfali and Dr. Ball from the UK DBA data.

All of the RPS and RPL mutations known to date are wither auto dominant or new sporadic mutations. Gata1 is inherited as X-linked.

We do recommend that persons with an affected family member be screened with a CBC and erythrocyte ADA activity, and take particular interest if there are family members with congenital anomalies. If a genetic mutation is found in the proband then we do offer genetic testing on the immediate family members.

There was an abstract years ago of a child (age 10) who was a donor for her younger brother with DBA. She was clinically well. Unfortunately the BM did not engraft and 3 years later, at her puberty, the donor presented with anemia and was found to have an elevated eADA.

Having said this, your questions pose an interesting discussion. We of course would not screen the general population for any of these autosomal dominant disorders in a standard way. However if the donor had an affected child and a mutation was known on that child then she should be screened for the same mutation, even if her CBC and eADA were normal. We identify family members all the time in our screening that have the mutation and are "silent" at this time. We don't know what they will do in the future - as we have had patients present as adults. Most importantly, we believe that this bone marrow would probably not engraft well into the patient.

If the mother is negative for the mutation her child has, then there is a small chance of gonadal mosaicism but this would not affect her being a BM donor.

If she was positive I would not count her as a BM donor.

If there is no gene identified then the CBC and eADA could be used as screening tools. If no anemia, macrocytosis or elevated eADA then the accepting physician could make the call about using the donor, especially if this was the only one for that patient.

Inherited Blood Disorder, family history of

2013-08-21T11:15:12Z

Dr Robert Lown: /* Date of Last Update */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital diserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known.

===At recruitment===

May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

===At CT/Work-up===

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
21st August 2013

Inherited Blood Disorder, family history of

2013-08-21T11:14:47Z

Dr Robert Lown: /* =At recruitment */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital diserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known.

===At recruitment===

May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

===At CT/Work-up===

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Inherited Blood Disorder, family history of

2013-08-21T11:14:35Z

Dr Robert Lown: PAge created and updated

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital diserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known.

===At recruitment==

May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.

===At CT/Work-up===

May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.

See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Inherited Blood Disorder, family history of

2013-08-21T11:09:40Z

Dr Robert Lown: /* Explanation of Condition */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital diserythropoietic anaemia, and inherited immune deficiencies such as Wiscott-Aldrich Syndrome.

Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.

==Guidance==

Refer all cases to the medical officer.

Details of the inherited disease should be noted, as well as the underlying mutation, if known. May join the register only if the potential donor has been tested for this mutation and found to not carry it. Alternatively, if alternative tests exist which make carriage of a particular mutation likelyIf necessary discuss the Specific guidance

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Inherited Blood Disorder, family history of

2013-08-21T11:09:06Z

Dr Robert Lown:

Inherited Blood Disorder, family history of

2013-08-21T11:03:02Z

Dr Robert Lown:

Inherited Blood Disorder, family history of

2013-08-21T11:01:18Z

Dr Robert Lown:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and

==Guidance==
Likely autoimmune aetiology, though unclear. Inform TC if identified at CT/workup.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Inherited Blood Disorder, family history of

2013-08-21T11:01:09Z

Dr Robert Lown:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemaglobin Disorder]]s Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and

==Guidance==
Likely autoimmune aetiology, though unclear. Inform TC if identified at CT/workup.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Inherited Blood Disorder, family history of

2013-08-21T11:00:31Z

Dr Robert Lown: page created

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disorders of blood production include such disorders as [[Haemaglobinopathy]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and

==Guidance==
Likely autoimmune aetiology, though unclear. Inform TC if identified at CT/workup.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Main Page

2013-08-21T10:58:32Z

Dr Robert Lown: /* I */

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

'''02/05/14. Guidance updated:''' [[Retinoic Acid Derivatives]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, see [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Blood Disorder, family history of]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Main Page

2013-08-21T10:57:28Z

Dr Robert Lown: /* I */ added inherited blood disorder

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

'''02/05/14. Guidance updated:''' [[Retinoic Acid Derivatives]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, see [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Blood Disorder]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Main Page

2013-08-21T10:57:02Z

Dr Robert Lown: /* I */

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

'''02/05/14. Guidance updated:''' [[Retinoic Acid Derivatives]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, see [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited blood disorder]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

South American Trypanosomiasis

2013-08-20T15:45:57Z

Dr Robert Lown: Changed to align with WMDA guidance

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
NOT ACCEPTABLE

==Individual at Risk==
Recipient

==Explanation of Condition==
Infection caused by the parasite trypanasoma cruzi, and spread by the triatomine bug. Also known as Chagas disease, it is endemic to many parts of South and Central America. May be fatal if untreated, and may be transferred via blood or bone marrow.

See also [http://en.wikipedia.org/wiki/Chagas_disease Chagas Disease]

==At RECRUITMENT==

A past history of Chagas’ disease should trigger permanent exclusion.

A history of being born or transfused with blood in a Chagas’ endemic area should trigger serological testing to quantify risk.

==At CT/WORK-UP==

A past history of Chagas’ disease may be acceptable if no evidence of acute or chronic infection, at the discretion of the requesting transplant centre.

A history of being born or transfused with blood in a Chagas’ endemic area should trigger serological testing to quantify risk.

A history of being transfused with blood in a Chagas’ endemic area should trigger serological testing to quantify risk.

==Justification for guidance==

The causative organism of Chagas’ disease is the protozoan Trypanosoma cruzi. The infection is a zoonosis that is transmitted to humans by bloodsucking insects of the Reduviidae family (kissing bugs), triatomine subfamily. The animal reservoir includes over 150 species of both wild and domestic mammals.
Infection is life-long, but approximately 70% of infected individuals will remain asymptomatic. Furthermore, parasitaemia occurs not only during the acute phase of infection, but also during asymptomatic chronic phases (albeit intermittently and at low levels).

Accordingly, Chagas’ is well-known to be transfusion-transmissible and asymptomatic parasitaemia has been detected in blood donors. Cases of transmission via solid organ transplantation have also been reported. Though platelet concentrates are the most frequently reported means of transmission, T. cruzi is able to survive refrigeration, freezing and thawing.

Chagas’ is endemic to mainland Latin America; however, the common modes of transmission are such that the risk to travellers is minimal. Instead, the people most at risk are those who spend early childhood in an endemic area in certain types of dwelling, those who receive blood transfusions in endemic areas, and children whose mothers grew up at risk of Chagas’ disease.
Most of this risk can be captured by asking donors their country of birth and whether they have ever received a blood transfusion in a Chagas’-endemic country. The former can be definitively captured at recruitment, while the latter could occur at any time up to work-up.

The detection of antibodies to T. cruzi is an established strategy to prevent transmission of infection through blood transfusion. Where available, this strategy can be adapted to assess the risk of prospective HPC donors with identified risk factors for chronic, asymptomatic Chagas’ disease. Because the prevalence of Chagas’ disease varies widely within the populations of endemic areas, it is likely that most donors with identified risk factors – especially those residing in non-endemic countries – will test negative for T. cruzi antibodies.

The most commonly used format for serological assays is the enzyme-linked immunosorbent assay (ELISA). A number of commercially available ELISAs are available and two have been licensed by the Food and Drug Administration (FDA) in the US. Other serological assay formats include particle agglutination (PA) and indirect haemagglutination assay (IHA). The Abbott Diagnostics ESA Chagas, an enzyme strip assay, is the only confirmatory assay to be approved by the FDA.

==References==

1 Kirchhoff LV. Trypanosoma Species (American Trypanosomiasis, Chagas’ Disease): Biology of Trypanosomes. In Mandell GL, Bennett JE and Dolin R, editors. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 6th ed, 2005:2622-2630.

2 Moncayo A and Silveira AC. Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy. Mem Inst Oswaldo Cruz 2009; 104 (Suppl. 1):17-30.

3 Teixeira AR, Hecht MM, Guimaro MC, Sousa AO, Nitz N. Pathogenesis of Chagas’ disease: parasite persistence and autoimmunity. Clin Microbiol Revs 2011; 24: 592-630.

4 Oliveira I, Torrico F, Munoz J and Gascon J. Congenital transmission of Chagas disease: a clinical approach. Expert Rev Anti Infect Ther 2010; 8:945-956.

5 Stramer SL, Hollinger, FB, Katz, LM, Kleinman, S, Metzel PS, Gregory KR, Dodd, R. Emerging infectious disease agents and their potential threat to transfusion safety. Transfusion. 49. August 2009. Supplement.

6 Schmunis GA. Epidemiology of Chagas disease in non-endemic countries: the role of international migration. Mem Inst Oswaldo Cruz 2007; 102 (Suppl.I):75-85.

7 Albajar-Vinas P. The hidden Chagas disease burden in Europe. Euro Surveill.2011;16(38):pii=19975.

8 Castro E. Chagas’ disease: lessons from routine donation testing. Transfusion Med 2009; 19:16-23.

9 Leiby DA, Herron RM Jr, Garratty G and Herwaldt BL. Trypanosoma cruzi parasitaemia in US blood donors with serologic evidence of infection. J Infect Dis 2008; 198:609-613.

10 CDC. Chagas disease after organ transplantation – Los Angeles, California, 2006. MMWR 2006; 55:798-800.

11 Bern C, Montgomery SP, Katz L, Caglioti S and Stramer SL. Chagas disease and the US blood supply. Curr Opin Infect Dis 2008; 21:476-482.

12 Primavera KS, Umezawa ES, Peres BA, Camargo ME, Hoshino-Shimizu S. Chagas'disease: IgA, IgM and IgG antibodies to T. cruzi amastigote, trypomastigote and epimastigote antigens in acute and in different chronic forms of the disease. Rev Inst Med Trop Sao Paulo. 1990 May-Jun;32(3):172-80.

13 Young C, Losikoff P, Chawla A, Glasser L and Forman E. Transfusion-acquired Trypanosoma cruzi infection. Transfusion 2007; 47:540-544.

Breast Feeding

2013-08-20T12:24:06Z

Dr Robert Lown: /* Guidance */ guidance updated to reflect evidence on G-CSF secretion in breast milk.

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

==Guidance==

We generally recommend that breast-feeding mothers do not donate and, regardless of breast-feeding, donation is not permitted within nine months of a term pregnancy.

However, many breast-feeding donors who are more than nine months following delivery feel very strongly that they would like to donate, and would be prepared to stop or suspend breast-feeding at the time of donation.

'''PBSC harvest'''

G-CSF is known to be secreted in breast milk (Kaida et al, Act Haematol 2007): it is unknown whether oral G-CSF would have any clinical effect on the infant.

Breast-feeding donors may donate by PBSC if they are prepared to stop breast-feeding on commencing G-CSF injections and to abstain for one week following the last dose of G-CSF. It is safe for the mother to express before this one-week period has expired, but the expressed milk should be discarded.

'''Bone marrow harvest'''

Anaesthetic drugs are generally very short-lived in the maternal blood stream. Breast-feeding may continue up until anaesthetic induction prior to the bone marrow harvest, and mothers may recommence feeding 24 hours following recovery from anaesthetic, i.e after 'waking up'. If any other medications are given around the time of the procedure, such as sedating benzodiazepines (e.g. midazolam/diazepam), or opiates (e.g. morphine/codeine) then advice should be sought from the attending anaesthetist.

See also

[[Pregnancy]]

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
24th October 2012

Malaria

2013-08-15T16:19:09Z

Dr Robert Lown: /* If the donor has visited an endemic area and has not suffered a febrile illness */ added caveat of visit within last three years (following discussion at collection centre meeting)

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
====If the donor has visited an endemic area within the last three years and has not suffered a febrile illness====
Acceptable if more than six months have passed since return from an endemic area, and a validated test for malaria antibody is negative. If less than six months has passed, and if the donor has taken a full course of prophylaxis and a validated test for malaria antibody is negative, the donor may proceed at the transplant centre's discretion.

====If the donor has had malaria diagnosed====
Accept if more than three years have passed since recovery and a validated test for malaria antibody is negative. At recruitment, donors may be encouraged to join when this three year period has elapsed.

====If the donor has had a febrile illness whilst in a malaria endemic area====
Accept if more than six months have passed since recovery, or return from an endemic area, whichever was the later, and a validated test for malaria antibody is negative.

====If the donor has lived in a endemic area for a continuous period of six months or more at any time in their life====
Accept if more than six months have passed since their return and a validated test for malaria antibody is negative.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Weight

2013-05-23T13:58:06Z

Dr Robert Lown: changed imperial weight to 7st12lb

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==
Acceptable for PBSC if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

Acceptable for BM if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

Donors outside these limits at work-up should be discussed with the medical officer who may allow them to proceed after discussion with the Chief Medical Officer or Medical Director.

Greater discretion may be used with overweight PBSC (rather than BM) donors, in whom an increased risk is less clear.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 2

====Date of Last Update====
23rd May 2013

Main Page

2013-05-02T17:00:43Z

Dr Robert Lown: /* Recently Updated Guidance */

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

'''02/05/14. Guidance updated:''' [[Retinoic Acid Derivatives]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Main Page

2013-05-02T17:00:18Z

Dr Robert Lown: /* Recently Updated Guidance */

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

'''02/05/14. Guidance updated:''' [[Retinoic acid derivatives]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Retinoic Acid Derivatives

2013-05-02T16:59:38Z

Dr Robert Lown: /* Guidance */ updated to be more permissive

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
A group of drugs used to treat a number of inflammatory conditions, such as acne or psoriasis.

However, they can cause severe congenital defects if given to pregnant women.

==Guidance==
Generally unacceptable if ever taken Etretinate (Tigason). Donors having taken, or currently taking, acitretin (Neotigason) or Isotretinoin (Roaccutane) may join the register.

At CT, inform the transplant centre if a donor is taking these medications, or has done so at any point in the last 12 months.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

West Nile Virus

2013-03-26T15:56:55Z

Dr Robert Lown: /* Acceptable */

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Infection causing fever and, rarely, encephalitis (brain inflammation). It is transmitted by a mosquito bite in endemic areas.

See also [http://en.wikipedia.org/wiki/West_Nile_virus West Nile Virus]

==Guidance==
Discuss with medical officer.

====Unacceptable====
Diagnosed with, or had a febrile illness consistent with, West Nile Virus less than six months ago;

Less than four weeks since returning from an area in which WNV is thought to be endemic, if WNV NAT (nucleic acid test) testing is unavailable;

====Acceptable====
More than 6 months has passed since the resolution of symptoms from a confirmed or suspected infection;

More than 4 weeks from return from an endemic area if the donor has shown no symptoms of infection;

Less than 4 weeks from return from an endemic area if the donor has shown no symptoms of infection, and a validated WNV NAT is negative

For the most up to date advice on areas with endemic WNV, refer to the [http://www.transfusionguidelines.org.uk/index.aspx?Publication=GDRI&Section=66 Geographical Disease Risk Index]

==Pseudonyms or Related Conditions==
WNV

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

West Nile Virus

2013-03-26T15:56:39Z

Dr Robert Lown: /* Acceptable */ slight modification to acceptable

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Infection causing fever and, rarely, encephalitis (brain inflammation). It is transmitted by a mosquito bite in endemic areas.

See also [http://en.wikipedia.org/wiki/West_Nile_virus West Nile Virus]

==Guidance==
Discuss with medical officer.

====Unacceptable====
Diagnosed with, or had a febrile illness consistent with, West Nile Virus less than six months ago;

Less than four weeks since returning from an area in which WNV is thought to be endemic, if WNV NAT (nucleic acid test) testing is unavailable;

====Acceptable====
More than 6 months has passed since the resolution of symptoms from a confirmed or suspected infection;
More than 4 weeks from return from an endemic area if the donor has shown no symptoms of infection;
Less than 4 weeks from return from an endemic area if the donor has shown no symptoms of infection, and a validated WNV NAT is negative

For the most up to date advice on areas with endemic WNV, refer to the [http://www.transfusionguidelines.org.uk/index.aspx?Publication=GDRI&Section=66 Geographical Disease Risk Index]

==Pseudonyms or Related Conditions==
WNV

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Surgery

2013-03-26T15:15:28Z

Dr Robert Lown: /* Acceptability at CT / Work-Up */ added caveat regarding proceeding even with recent surgery

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED - if a donor needs to be deferred due to surgery, it is possible for them to proceed with CT, as the time period between CT and donation is usually several months.

==Individual at Risk==
Donor / Recipient

==Explanation of Condition==

==Guidance==

====Questions to ask:====

When was the operation?

What was it performed for?

Was it performed under general or local anaesthetic?

Did you have any complications from the operation or general anaesthetic?

Is the wound fully healed?

Are you still under follow-up by the surgeon who performed the operation?

====Unacceptable====
If for malignancy or any other cause which may prohibit donation, such as inflammatory bowel disease.

====Acceptable====
Most other procedures. Each case should be discussed with the medical officer at CT.

In general, seven days should be allowed after minor procedures (such as dental procedures and excision of skin lesions) and four months after major surgical procedures.

This time period may be shortened as long as:

All wounds are fully healed;

Any post-operative infection is fully resolved;

Normal mobility is regained;

Regular post-operative follow-up is no longer required (this excludes follow-up for the underlying condition).

====Donation before operation====
Occasionally a donor will require an operation shortly after donation. In these circumstances the donor should donate by PBSC only, in order not to compromise pre-operative body iron and haemoglobin levels.

==Pseudonyms or Related Conditions==
Operation

==Version==
Version 1, Edition 1

====Date of Last Update====
26th June 2012

Main Page

2013-01-04T20:12:38Z

Dr Robert Lown: updated weight guidance

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

'''04/01/13. Guidance updated:''' [[Weight]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Weight

2013-01-04T20:10:57Z

Dr Robert Lown: Altered to reflect new BMI guidance

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==
Acceptable for PBSC if over 8 stone (or 50kg) and BMI less than, or equal to, 40.0.

Acceptable for BM if over 8 stone (or 50kg) and BMI less than, or equal to, 35.0.

Donors outside these limits at work-up should be discussed with the medical officer who may allow them to proceed after discussion with the Chief Medical Officer or Medical Director.

Greater discretion may be used with overweight PBSC (rather than BM) donors, in whom an increased risk is less clear.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Vasculitis

2012-10-30T11:18:56Z

Dr Robert Lown: /* Pseudonyms or Related Conditions */ added HSP

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
NOT ACCEPTABLE

==Individual at Risk==
Recipient

==Explanation of Condition==
Autoimmune condition affecting blood vessels and usually a number of major organs.

See also [http://en.wikipedia.org/wiki/Vasculitis Vasculitis]

==Guidance==
Unacceptable if current suffering from, or has a history of, any vasculitic conditions.

==Pseudonyms or Related Conditions==
Churg-Strauss Syndrome

Henoch-Schonlein Purpura

Wegeners granulomatosis

Polyarteritis nodosa

Takayusu arteritis

Temporal arteritis

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Main Page

2012-10-24T11:40:58Z

Dr Robert Lown: /* Appendix 3 - Other investigations at donor medical */

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=
'''20/6/12. Guidance Added:''' [[Essential Tremor]]

'''21/6/12. Guidance Added:''' Bronchitis, See [[Infection, Acute]]

'''22/6/12. Guidance Added:''' [[POTS (Postural Orthostatic Tachycardia Syndrome)]]

'''26/6/12. Guidance Updated:''' [[Surgery]]

'''28/6/12. Guidance Added:''' Blood Clot, See [[Thrombosis]]

'''11/7/12. Guidance Added:''' [[Cluster Headache]]

'''18/7/12. Guidance Added:''' [[Haemangioma]]

'''18/7/12. Guidance Updated:''' [[Alopecia]]

'''8/8/12. Guidance Updated:''' [[Non Steroidal Anti-Inflammatory Drug]]

'''22/8/12. Guidance Added:''' [[Gout]]

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

Electrocardiogram (ECG)

Chest X-ray

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Main Page

2012-10-24T10:56:03Z

Dr Robert Lown: /* Recently Updated Guidance */ added breast feeding

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=
'''20/6/12. Guidance Added:''' [[Essential Tremor]]

'''21/6/12. Guidance Added:''' Bronchitis, See [[Infection, Acute]]

'''22/6/12. Guidance Added:''' [[POTS (Postural Orthostatic Tachycardia Syndrome)]]

'''26/6/12. Guidance Updated:''' [[Surgery]]

'''28/6/12. Guidance Added:''' Blood Clot, See [[Thrombosis]]

'''11/7/12. Guidance Added:''' [[Cluster Headache]]

'''18/7/12. Guidance Added:''' [[Haemangioma]]

'''18/7/12. Guidance Updated:''' [[Alopecia]]

'''8/8/12. Guidance Updated:''' [[Non Steroidal Anti-Inflammatory Drug]]

'''22/8/12. Guidance Added:''' [[Gout]]

'''24/10/12. Guidance Added:''' [[Breast Feeding]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Breast Feeding

2012-10-24T09:59:53Z

Dr Robert Lown: Page created.

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

==Guidance==

We generally recommend that breast-feeding mothers do not donate and, regardless of breast-feeding, donation is not permitted within nine months of a term pregnancy.

However, many breast-feeding donors who are more than nine months following delivery feel very strongly that they would like to donate, and would be prepared to stop or suspend breast-feeding at the time of donation.

'''PBSC harvest'''

It is unknown whether Lenograstim (G-CSF) is secreted in breast milk, or whether oral G-CSF would have any clinical effect on the infant.

Breast-feeding donors may donate by PBSC if they are prepared to stop breast-feeding on commencing G-CSF injections and to abstain for one week following the last dose of G-CSF. It is safe for the mother to express before this one-week period has expired, but the expressed milk should be discarded.

'''Bone marrow harvest'''

Anaesthetic drugs are generally very short-lived in the maternal blood stream. Breast-feeding may continue up until anaesthetic induction prior to the bone marrow harvest, and mothers may recommence feeding 24 hours following recovery from anaesthetic, i.e after 'waking up'. If any other medications are given around the time of the procedure, such as sedating benzodiazepines (e.g. midazolam/diazepam), or opiates (e.g. morphine/codeine) then advice should be sought from the attending anaesthetist.

See also

[[Pregnancy]]

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
24th October 2012

Main Page

2012-10-24T09:44:19Z

Dr Robert Lown: /* B */ Added Breast Feeding

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=
'''20/6/12. Guidance Added:''' [[Essential Tremor]]

'''21/6/12. Guidance Added:''' Bronchitis, See [[Infection, Acute]]

'''22/6/12. Guidance Added:''' [[POTS (Postural Orthostatic Tachycardia Syndrome)]]

'''26/6/12. Guidance Updated:''' [[Surgery]]

'''28/6/12. Guidance Added:''' Blood Clot, See [[Thrombosis]]

'''11/7/12. Guidance Added:''' [[Cluster Headache]]

'''18/7/12. Guidance Added:''' [[Haemangioma]]

'''18/7/12. Guidance Updated:''' [[Alopecia]]

'''8/8/12. Guidance Updated:''' [[Non Steroidal Anti-Inflammatory Drug]]

'''22/8/12. Guidance Added:''' [[Gout]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Breast Feeding]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Liver Function, Abnormal

2012-10-16T09:23:55Z

Dr Robert Lown: Page created

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor, Recipient

==Explanation of Condition==
Abnormality of bilirubin and/or one or more of the standard enzyme tests used to assess liver function. These include:

ALT (Alanine transaminase)

AST (Aspartate transaminase)

ALP (Alkaline phosphatase)

GGT (Gamma-glutamyl transpeptidase)

==Guidance==
Acceptable if less than twice the upper limit of normal (as defined by local reference ranges).

If greater than twice upper limit of normal, discuss with medical officer.

LFTs greater than twice upper limit of normal but less than thrice upper limit of normal discovered at pre-harvest medical: arrange urgent liver ultrasound. Accept if normal or fatty liver, and standard hepatitis screen is negative. Inform transplant centre.

==Pseudonyms or Related Conditions==

LFT

LFTs

==Version==
Version 1, Edition 1

====Date of Last Update====
16th October 2012

Main Page

2012-10-16T09:18:14Z

Dr Robert Lown: /* L */ added liver function

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=
'''20/6/12. Guidance Added:''' [[Essential Tremor]]

'''21/6/12. Guidance Added:''' Bronchitis, See [[Infection, Acute]]

'''22/6/12. Guidance Added:''' [[POTS (Postural Orthostatic Tachycardia Syndrome)]]

'''26/6/12. Guidance Updated:''' [[Surgery]]

'''28/6/12. Guidance Added:''' Blood Clot, See [[Thrombosis]]

'''11/7/12. Guidance Added:''' [[Cluster Headache]]

'''18/7/12. Guidance Added:''' [[Haemangioma]]

'''18/7/12. Guidance Updated:''' [[Alopecia]]

'''8/8/12. Guidance Updated:''' [[Non Steroidal Anti-Inflammatory Drug]]

'''22/8/12. Guidance Added:''' [[Gout]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

[[Liver Function, Abnormal]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Schizophrenia

2012-10-16T08:03:57Z

Dr Robert Lown: /* Pseudonyms or Related Conditions */

==Acceptability at Recruitment==
UNACCEPTABLE

==Acceptability at CT / Work-Up==
UNACCEPTABLE

==Individual at Risk==
Donor/Recipient

==Explanation of Condition==
Mental health disorder characterised by a breakdown of though processes and poor emotional responsiveness.

Donors with active schizophrenia may not be able to give fully informed consent.

See also [http://en.wikipedia.org/wiki/Schizophrenia Schizophrenia]

==Guidance==
Unacceptable if current diagnosis of schizophrenia. Donors with a past history of schizophrenia, but currently off medication and not requiring regular psychiatric follow-up may join/donate following discussion with the medical officer.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
16th October 2012

Schizophrenia

2012-10-16T08:03:23Z

Dr Robert Lown:

==Acceptability at Recruitment==
UNACCEPTABLE

==Acceptability at CT / Work-Up==
UNACCEPTABLE

==Individual at Risk==
Donor/Recipient

==Explanation of Condition==
Mental health disorder characterised by a breakdown of though processes and poor emotional responsiveness.

Donors with active schizophrenia may not be able to give fully informed consent.

See also [http://en.wikipedia.org/wiki/Schizophrenia Schizophrenia]

==Guidance==
Unacceptable if current diagnosis of schizophrenia. Donors with a past history of schizophrenia, but currently off medication and not requiring regular psychiatric follow-up may join/donate following discussion with the medical officer.

==Pseudonyms or Related Conditions==
Degenerative arthritis

==Version==
Version 1, Edition 1

====Date of Last Update====
16th October 2012

Schizophrenia

2012-10-16T08:03:08Z

Dr Robert Lown: Page created.

==Acceptability at Recruitment==
UNACCEPTABLE

==Acceptability at CT / Work-Up==
UNACCEPTABLE

==Individual at Risk==
Donor/Recipient

==Explanation of Condition==
Mental health disorder characterised by a breakdown of though processes and poor emotional responsiveness.

Donors with active schizophrenia may not be able to give fully informed consent.

See also [http://en.wikipedia.org/wiki/Schizophrenia Schizophrenia]

==Guidance==
Unacceptable if current diagnosis of schizophrenia. Donors with a past history of schizophrenia, but currently off medication and not requiring regular psychiatric follow-up may join/donate following discussion with the medical officer.

==Pseudonyms or Related Conditions==
Degenerative arthritis

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Main Page

2012-10-16T07:56:21Z

Dr Robert Lown: /* S */ Added schizophrenia

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=
'''20/6/12. Guidance Added:''' [[Essential Tremor]]

'''21/6/12. Guidance Added:''' Bronchitis, See [[Infection, Acute]]

'''22/6/12. Guidance Added:''' [[POTS (Postural Orthostatic Tachycardia Syndrome)]]

'''26/6/12. Guidance Updated:''' [[Surgery]]

'''28/6/12. Guidance Added:''' Blood Clot, See [[Thrombosis]]

'''11/7/12. Guidance Added:''' [[Cluster Headache]]

'''18/7/12. Guidance Added:''' [[Haemangioma]]

'''18/7/12. Guidance Updated:''' [[Alopecia]]

'''8/8/12. Guidance Updated:''' [[Non Steroidal Anti-Inflammatory Drug]]

'''22/8/12. Guidance Added:''' [[Gout]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

[[Schizophrenia]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Costochondritis

2012-10-16T07:49:12Z

Dr Robert Lown: Page created

Costochondritis

2012-10-16T07:47:32Z

Dr Robert Lown: Created page with "==Acceptability at Recruitment== ACCEPTABLE ==Acceptability at CT / Work-Up== ACCEPTABLE ==Individual at Risk== ==Explanation of Condition== Inflammation of cartilage, usu..."

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
ACCEPTABLE

==Individual at Risk==

==Explanation of Condition==
Inflammation of cartilage, usually in the ribs. A common cause of chest pain which may mimic that of a pulmonary embolism or underlying pleural inflammation. See also

==Guidance==
Acceptable at recruitment due to minimum six month deferral from joining to being made available on the register.

Acceptable at CT/work-up only if performed by a NHS healthcare provider, or an independent practitioner who is subject to discipline by a statutory body, including:

The General Medical Council

The Nursing and Midwifery Council

The General Dental Council

The General Chiropractic Council

The General Optical Council

The General Osteopathic Council

The Health Professions Council

If evidence of the above is not given, then a minimum 4 month deferral period applies at CT/Work-up. However, this may be reduced at the discretion of the transplant centre.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Main Page

2012-10-16T07:46:22Z

Dr Robert Lown: /* C */ added costochondritis

=About the Anthony Nolan Medical and Lifestyle Guidelines=

For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.

The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.

Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.

Some donor medical conditions present a risk to the '''recipient''' of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.

=Guidance for Recruiters=

The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.

IN SUCH CASES PLEASE NOTE THE FOLLOWING:
The volunteer should be asked to complete an application form giving full details of their
medical status ensuring that the following information is given:

*Name of medical condition.
*Date of diagnosis.
*Name of medication(s) taken.
*Length of time medication has been taken.
*Is the medication seen as a short course or long-term prescription?
*Does the volunteer have any limitations to life-style?
*Is the volunteer’s condition regularly assessed by GP/Consultant?

Once the application has been reviewed the donor will be contacted and informed
of the decision.

This list is in place to help us recruit medically eligible volunteer blood stem cell donors.
We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.

The criteria, which we use to assess the suitability of a volunteer to donate, are considerably
more stringent than those taken into consideration for volunteers undergoing a procedure for
their own medical health status.

If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:

Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or
E-mail: info@anthonynolan.org

=Recently Updated Guidance=
'''20/6/12. Guidance Added:''' [[Essential Tremor]]

'''21/6/12. Guidance Added:''' Bronchitis, See [[Infection, Acute]]

'''22/6/12. Guidance Added:''' [[POTS (Postural Orthostatic Tachycardia Syndrome)]]

'''26/6/12. Guidance Updated:''' [[Surgery]]

'''28/6/12. Guidance Added:''' Blood Clot, See [[Thrombosis]]

'''11/7/12. Guidance Added:''' [[Cluster Headache]]

'''18/7/12. Guidance Added:''' [[Haemangioma]]

'''18/7/12. Guidance Updated:''' [[Alopecia]]

'''8/8/12. Guidance Updated:''' [[Non Steroidal Anti-Inflammatory Drug]]

'''22/8/12. Guidance Added:''' [[Gout]]

=Multiple Medical Conditions=

Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.

For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.

If in doubt, please discuss these donors with the medical officer.

=Index of Conditions=

==A==

Accident, See [[Fracture]] and/or [[Surgery]]

[[Acetylcholinesterase Deficiency]]

[[Achondroplasia]]

Acitretin, See [[Acne]]

[[Acne]]

[[Acoustic Neuroma]]

Acoustic Schwannoma, See [[Acoustic Neuroma]]

[[Acromegaly]]

[[Actinic Prurigo]]

[[Acupuncture]]

ADD, See [[Attention Deficit Hyperactivity Disorder]]

[[Addiction and Drug Abuse]]

[[Addison Disease]]

Adenocarcinoma, See [[Malignancy]]

[[Adenoma]]

ADHD, See [[Attention Deficit Hyperactivity Disorder]]

Adrenal Hyperplasia, See [[Congenital Adrenal Hyperplasia]]

[[African Trypanosomiasis]]

AIDS, See [[HIV]]

[[Albino]]

[[Alcohol Intake]]

[[Allergy]]

[[Alopecia]]

[[Alpha 1 Antitrypsin Deficiency]]

[[Alpha Mannosidosis]]

[[Alports Syndrome]]

Anabolic Steroids, See [[Addiction and Drug Abuse]]

[[Anaemia]]

[[Anaesthetic Complications]]

Angina, See [[Heart, Coronary Artery Disease]]

[[Animal Bite]]

[[Ankylosing Spondylitis]]

Anthrax Vaccine, See [[Immunisation]]

Anti-Inflammatory Drug, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Anti-Phospholipid Syndrome]]

[[Antibiotic Treatment]]

[[Antibodies]]

[[Anticoagulants]]

Anticonvulsants, See [[Epilepsy]]

Antithrombin Deficiency, See [[Thrombophilia]]

[[Anxiety Disorder]]

Aortic Regurgitation, See [[Heart, Valve Disease]]

Aortic Stenosis, See [[Heart, Valve Disease]]

Aortic Valve Disease, See [[Heart, Valve Disease]]

[[Arachnoid Cyst]]

[[Arnold-Chiari Syndrome]]

Arrhythmia, See [[Heart, Arrhythmia]]

[[Arthrogryposis]]

Arthroscopy, See [[Surgery]]

[[Asperger Syndrome]]

Aspirin, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Asthma]]

Atherosclerosis, See [[Heart, Coronary Artery Disease]]

Atrial Fibrillation, See [[Heart, Arrhythmia]]

Atrial Myxoma, See [[Myxoma]]

Atrial Septal Defect (ASD), See [[Heart, Congenital Defect]]

[[Attention Deficit Hyperactivity Disorder]]

[[Avascular Necrosis]]

Avodart, See [[Dutasteride]]

Avulsion Fracture (Other Than Spinal), See [[Fracture]]

Avulsion Fracture (Spinal), See [[Back Conditions]]

==B==

[[B12 Deficiency]]

[[Babesiosis]]

[[Back Conditions]]

[[Balanitis Xerotica Obliterans (BXO)]]

[[Basal Cell Carcinoma]]

BCG Vaccination, See [[Immunisation]]

[[Bells Palsy]]

Benign Essential Tremor, See [[Essential Tremor]]

Benign Ethnic Neutropenia, See [[Neutropenia]]

Benign Intracranial Hypertension, See [[Idiopathic Intracranial Hypertension]]

[[Benign Positional Vertigo]]

[[Benign Prostatic Hyperplasia]]

Berger Disease, See [[Kidney Disease]]

Beta Blockers, See [[Medications]]

Beta Thalassemia, See [[Haemoglobin Disorder]]

Bilateral Scleritis, See [[Eye Disease]]

Bilharzia, See [[Schistosomiasis]]

[[Bipolar Affective Disorder]]

Bisexual, See [[Sexual Orientation]]

[[Bleeding Disorder]]

Blocked Artery (Heart), See [[Heart, Coronary Artery Disease]]

Blood Clot, See [[Thrombosis]]

Blood Pressure, See [[Hypertension]]

Blood Transfusion, See [[Transfusion]]

[[Body Piercing]]

Bone Density (Abnormal), See [[Osteoporosis]]

Bone Graft, See [[Surgery]] and/or [[Back Conditions]]

Borreliosis, See [[Lyme Disease]]

Bowens Disease, See [[Malignancy]]

BPH, See [[Benign Prostatic Hyperplasia]]

Brain Surgery, See [[Neurosurgery]]

[[Brain Tumour]]

[[Breast Augmentation (Implants)]]

[[Bronchiectasis]]

Bronchitis, See [[Infection, Acute]]

Brown-Sequard Syndrome, See [[Central Nervous System Disease]]

[[Brucellosis]]

[[Bursitis]]

==C==

[[C1 Esterase Inhibitor Deficiency]]

Cancer, See [[Malignancy]]

[[Candida Infection]]

Candidiasis, See [[Candida Infection]]

Carcinoid Syndrome, See [[Malignancy]]

Cardiac Failure, See [[Heart, Muscle Disease]]

Cardiac Syndrome X, See [[Heart, Coronary Artery Disease]]

Cardiomegaly, See [[Heart, Muscle Disease]]

Cardiomyopathy, See [[Heart, Muscle Disease]]

[[Carpal Tunnel Syndrome]]

Cat-Scratch Fever, See [[Infection, Acute]]

[[Causalgia]]

Cellulitis, See [[Infection, Acute]]

[[Central Nervous System Disease]]

Cerebral Malaria, See [[Malaria]]

[[Cerebral Palsy]]

[[Cerebroretinal Angiomatosis]]

Cerebrovascular Accident, See [[Stroke]]

[[Cervical Carcinoma In-Situ]]

Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Cervical Spondylosis, See [[Back Conditions]]

Chagas Disease, See [[South American Trypanosomiasis]]

Charcot Marie Tooth Syndrome, See [[Hereditary Motor Sensory Neuropathy]]

[[Chicken Pox]]

Chlamydia, See [[Infection, Acute]]

Cholecystectomy, See [[Surgery]]

Cholecystitis, See [[Gall-Bladder Disease]]

[[Chondromalacia Patellae]]

Christmas Disease, See [[Bleeding Disorder]]

Chronic Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[Chronic Obstructive Pulmonary Disease]]

[[Cirrhosis]]

CJD, See [[Prion-Associated Disease]]

Clap, See [[Gonorrhoea]]

[[Clinical Trial]]

[[Cluster Headache]]

Coagulation Disorder, See [[Bleeding Disorder]] or [[Thrombophilia]]

Coccydynia, See [[Back Conditions]]

[[Coeliac Disease]]

[[Cold]]

Coldsore, See [[Herpes Simplex Virus]]

[[Colitis]]

Cone Biopsy, See [[Cervical Carcinoma In-Situ]]

[[Congenital Adrenal Hyperplasia]]

Congenital Dwarfism, See [[Achondroplasia]]

[[Congenital Naevus]]

[[Congo Fever]]

Conn Syndrome, See [[Hyperaldosteronism]]

[[Conversion Disorder]]

COPD, See [[Chronic Obstructive Pulmonary Disease]]

[[Corneal Transplant]]

Coronary Artery Disease, See [[Heart, Coronary Artery Disease]]

Coronary Thrombosis, See [[Heart, Coronary Artery Disease]]

[[Costochondritis]]

[[Cow Pox]]

Coxsackie Virus, See [[Infection, Acute]]

Creutzfeld-Jacob Disease, See [[Prion-Associated Disease]]

[[Crigler-Najjar Sydrome]]

Crimean Fever, See [[Brucellosis]]

Crimean-Congo Haemorrhagic Fever, See [[Congo Fever]]

Crohns Disease, See [[Inflammatory Bowel Disease]]

Crush Fracture (Spinal), See [[Back Conditions]]

[[Cushing Syndrome/Disease]]

Cutaneous Leishmaniasis, See [[Leishmaniasis]]

[[Cystic Fibrosis]]

[[Cystic Fibrosis Carrier]]

[[Cystinuria]]

[[Cysts]]

[[Cytomegalovirus]]

==D==

[[Darier Disease]]

Deep Vein Thrombosis, See [[Thrombosis]]

Dengue Fever, See [[Infection, Acute]]

[[Depression]]

[[Dermatitis]]

[[Dermatitis Herpetiformis]]

[[Dermatomyositis]]

[[Dextrocardia]]

[[Diabetes Insipidus]]

[[Diabetes Mellitus]]

Diamond-Blackfan Syndrome, See [[Inherited Disease]]

Diclofenac, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Disabled Volunteer]]

Disc (Removal/Micro Discectomy), See [[Back Conditions]]

Disc Protrusion/Prolapse, See [[Back Conditions]]

Discoid Lupus, See [[Systemic Lupus Erythematosus]]

[[Diverticulitis]]

Double-Jointed, See [[Hypermobility Syndrome]]

[[Down Syndrome]]

Drug Abuse, See [[Addiction and Drug Abuse]]

Drug Treatment, See [[Medications]]

Drug Trial, See [[Clinical Trial]]

[[Duodenal Ulcer]]

[[Duplex Kidney]]

[[Dutasteride]]

Dwarfism, See [[Achondroplasia]]

Dysentery, See [[Infection, Acute]]

Dysfibrinogenaemia, See [[Bleeding Disorder]]

Dyspepsia, See [[Gastro-Oesophageal Reflux]]

[[Diastasis Symphysis Pubis]]

Dystonia, See [[Central Nervous System Disease]]

==E==

[[Ebola Fever]]

EBV, See [[Epstein-Barr Virus]]

Eclampsia, See [[Pre-Eclampsia]]

[[Eczema]]

[[Ehlers-Danlos Syndrome]]

[[Electrolysis]]

Elephantiasis, See [[Filariasis]]

Emphysema, See [[Chronic Obstructive Pulmonary Disease]]

[[Encephalitis]]

[[Endocarditis]]

[[Endometriosis]]

[[Epidermolysis Bullosa]]

[[Epilepsy]]

Episcleritis, See [[Eye Disease]]

[[Epistaxis]]

[[Epstein-Barr Virus]]

ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

[[Erysipelas]]

[[Erythema Multiforme]]

[[Erythema Nodosum]]

[[Erythromelalgia]]

Essential Thrombocythemia, See [[Myeloproliferative Neoplasm]]

[[Essential Tremor]]

[[Eye Disease]]

==F==

[[Factor 12 (XII) Deficiency]]

Factor 5 Leiden, See [[Thrombophilia]]

Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See [[Bleeding Disorder]]

Factor V Leiden, See [[Thrombophilia]]

Familial Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Familial Mediterranean Fever]]

[[Familial Polyposis]]

[[Fat Embolism]]

Felty Syndrome, See [[Rheumatoid Arthritis]]

Fertility Treatment, See [[Hormone Replacement Therapy]]

[[Fibroids]]

[[Fibromyalgia]]

Fibrosarcoma, See [[Malignancy]]

[[Fibrosing Alveolitis]]

[[Filariasis]]

[[Finasteride]]

Flu, See [[Influenza]]

[[Folate Deficiency]]

[[Fracture]]

[[Fragile X Syndrome]]

==G==

[[G6PD Deficiency]]

[[Galactosaemia]]

[[Gall-Bladder Disease]]

Gallstones, See [[Gall-Bladder Disease]]

Gammopathy, See [[Malignancy]]

[[Ganglion]]

[[Gastrectomy]]

[[Gastric Ulcer]]

[[Gastritis]]

[[Gastro-Oesophageal Reflux]]

[[Gaucher Disease]]

[[Gender Reassignment]]

Genetic Traits, See [[Inherited Disease]]

Genital Herpes, See [[Herpes Simplex Virus]]

[[Genital Warts]]

[[Giant Cell Tumour]]

[[Giardiasis]]

[[Gilbert Syndrome]]

[[Gilles De La Tourette Syndrome]]

Glandular Fever, See [[Epstein-Barr Virus]]

Glaucoma, See [[Eye Disease]]

[[Glomerulonephritis]]

Gluten Intolerance, See [[Coeliac Disease]]

Goitre (Enlarged Thyroid), See [[Thyroid Disease]]

[[Gonorrhoea]]

[[Gout]]

[[Granuloma Annulare]]

Graves Disease, See [[Thyroid Disease]]

Growth Hormone Therapy, See [[Hormone Replacement Therapy]]

[[Guillain-Barre Syndrome]]

Guttate Psoriasis, See [[Psoriasis]]

==H==

H. Pylori, See [[Helicobacter Pylori]]

[[Haemangioma]]

[[Haematemesis]]

[[Haematuria]]

[[Haemochromatosis]]

Haemoglobin C, See [[Haemoglobin Disorder]]

Haemoglobin Camden, See [[Haemoglobin Disorder]]

Haemoglobin D, See [[Haemoglobin Disorder]]

[[Haemoglobin Disorder]]

Haemoglobin E, See [[Haemoglobin Disorder]]

Haemoglobin Level, See [[Anaemia]]

Haemoglobin S, , See [[Haemoglobin Disorder]]

[[Haemolytic Anaemia]]

[[Haemolytic Uraemic Syndrome]]

Haemophilia, See [[Bleeding Disorder]]

Haemophilia Carrier, See [[Bleeding Disorder]]

[[Hand Foot And Mouth]]

Hashimotos Thyroiditis, See [[Thyroid Disease]]

Heart Attack, See [[Heart, Coronary Artery Disease]]

Heart Block, See [[Heart, Arrhythmia]]

Heart Murmur, See [[Heart, Valve Disease]]

[[Heart, Arrhythmia]]

[[Heart, Congenital Defect]]

[[Heart, Coronary Artery Disease]]

[[Heart, Muscle Disease]]

[[Heart, Valve Disease]]

Heavy Periods, See [[Menorrhagia]]

[[Helicobacter Pylori]]

[[HELLP Syndrome]]

Henoch-Schonlein Purpura, See [[Vasculitis]]

[[Hepatitis A]]

[[Hepatitis B]]

[[Hepatitis C]]

[[Hepatitis E]]

[[Hepatitis Of Unknown Origin]]

[[Hereditary Elliptocytosis]]

[[Hereditary Haemorrhagic Telangiectasia]]

[[Hereditary Motor Sensory Neuropathy]]

Hereditary Polyposis, See [[Familial Polyposis]]

Hereditary Spastic Paraplegia, See [[Central Nervous System Disease]]

[[Hereditary Spherocytosis]]

[[Hernia]]

[[Herpes Simplex Virus]]

Herpes Zoster Virus, See [[Chicken Pox]]

High Affinity Haemoglobin, See [[Haemoglobin Disorder]]

High Cholesterol, See [[Hyperlipidaemia]]

[[High Risk Sexual Behaviour]]

[[Hip Dislocation]]

[[Hirschsprung’s Disease]]

[[HIV]]

Hodgkin Lymphoma, See [[Malignancy]]

[[Hormone Replacement Therapy]]

HRT, See [[Hormone Replacement Therapy]]

[[HTLV Infection]]

Hughes Syndrome, See [[Anti-Phospholipid Syndrome]]

Human Bite, See [[Innoculation Injury]]

Human Growth Hormone], See [[Hormone Replacement Therapy]]

Human Immunodeficiency Virus, See [[HIV]]

[[Human Papilloma Virus]]

[[Huntington Disease]]

Hydatidiform Mole, See [[Pregnancy]]

[[Hydradentis Suppurativa]]

[[Hydrocephalus]]

[[Hydronephrosis]]

[[Hyperaldosteronism]]

Hypercholesterolaemia, See [[Hyperlipidaemia]]

[[Hyperlipidaemia]]

[[Hypermobility Syndrome]]

[[Hyperparathyroidism]]

Hyperprolactinaemia, See [[Pituitary Adenoma]]

[[Hypertension]]

Hyperthyroidism, See [[Thyroid Disease]]

[[Hypertrophic Obstructive Cardiomyopathy]]

Hypoadrenalism, See [[Addison Disease]]

Hypofibrinogenaemia, See [[Bleeding Disorder]]

[[Hypogonadism]]

[[Hypoparathyroidism]]

[[Hypopituiarism]]

[[Hypotension]]

Hypothyroidism, See [[Thyroid Disease]]

Hysterectomy, See [[Surgery]]

==I==

Ibuprofen, See [[Non Steroidal Anti-Inflammatory Drug]]

[[Idiopathic Hypersomnia]]

[[Idiopathic Intracranial Hypertension]]

[[IgA Deficiency]]

IgA Nephropathy, See [[Kidney Disease]]

[[Ileostomy]]

Immune Deficiency, See [[Immunosuppression]]

[[Immune Thrombocytopenia]]

[[Immunisation]]

Immunoglobulin Therapy, See [[Transfusion]]

[[Immunosuppression]]

[[Impetigo]]

In-vitro Fertilisation, Seee [[Hormone Replacement Therapy]]

[[Infection, Acute]]

Infectious Mononucleosis, See [[Epstein-Barr Virus]]

Infective Endocarditis, See [[Endocarditis]]

[[Infertility]]

[[Inflammatory Bowel Disease]]

[[Influenza]]

Influenza Vaccination, See [[Immunisation]]

[[Inherited Disease]]

[[Innoculation Injury]]

Intermittent Claudication, See [[Peripheral Vascular Disease]]

[[Iron Deficiency (Anaemia)]]

[[Irritable Bowel Disease]]

Ischaemic Heart Disease, See [[Heart, Coronary Artery Disease]]

IVF, See [[Hormone Replacement Therapy]]

==J==

[[Jaundice]]

Juvenile Chronic Arthritis, See [[Juvenile Idiopathic Arthritis]]

[[Juvenile Idiopathic Arthritis]]

Juvenile Rheumatoid Arthritis, See [[Juvenile Idiopathic Arthritis]]

==K==

Kala-Azar, See [[Leishmaniasis]]

[[Kallman Syndrome]]

[[Kawasaki Disease]]

Key-Hole Surgery, See [[Surgery]]

[[Kidney Disease]]

Kidney Transplant, See [[Tissue Or Organ Transplant]]

[[Kidney, Single]]

Kienbock Disease, See [[Avascular Necrosis]]

[[Klinefelter Syndrome]]

Kyphosis, See [[Back Conditions]]

==L==

[[Labyrinthitis]]

Laminectomy, See [[Back Conditions]]

Laparoscopy, See [[Surgery]]

[[Laser Treatment]]

[[Lassa Fever]]

Latex Allergy, See [[Allergy]]

Left Branch Bundle Block, See [[Heart, Arrhythmia]]

[[Legionnaire's Disease]]

[[Leishmaniasis]]

[[Leptospirosis]]

Leukaemia, See [[Malignancy]]

[[Lichen Planus]]

[[Lichen Sclerosus]]

[[Lipoma]]

Low Blood Pressure, See [[Hypotension]]

Low Haemoglobin, See [[Anaemia]]

Low Platelets, See [[Thrombocytopenia]]

Lumbar Spine Abnormality, See [[Back Conditions]]

Lupus, See [[Systemic Lupus Erythematosus]]

[[Lupus Anticoagulant]]

[[Lyme Disease]]

[[Lymphadenopathy]]

[[Lymphoedema]]

[[Lymphogranuloma Venereum]]

==M==

[[Macrocytosis]]

[[Malaria]]

[[Malignancy]]

[[Malignant Hyperpyrexia]]

Malignant Melanoma, See [[Malignancy]]

Manic Depression, See [[Bipolar Affective Disorder]]

[[Marburg Fever]]

[[Marfan Syndrome]]

Mastectomy, See [[Surgery]]

[[Mastitis]]

Mastoid Operation, See [[Surgery]]

ME, See [[Myalgic Encephalomyelitis]]

Medical Trial, See [[Clinical Trial]]

[[Medications]]

[[Megaloblastic Anaemia]]

Membranous Glomerulonephritis, See [[Kidney Disease]]

[[Meniere Disease]]

Meningioma, See [[Brain Tumour]]

[[Meningitis]]

Meningoencephalitis, See [[Meningitis]]

[[Menopause]]

[[Menorrhagia]]

Metabolic Disease, Seee [[Inherited Disease]]

MGUS, See [[Monoclonal Gammopathy]]

Micropituitary Adenoma, See [[Pituitary Adenoma]]

[[Migraine]]

[[Miscarriage]]

Mitral Regurgitation, See [[Heart, Valve Disease]]

Mitral Stenosis, See [[Heart, Valve Disease]]

Mitral Valve Disease, See [[Heart, Valve Disease]]

[[Monoclonal Gammopathy]]

[[Mononeuritis]]

Mononucleosis, See [[Epstein-Barr Virus]]

[[Morphoea]]

Motor Neurone Disease, See [[Central Nervous System Disease]]

Motor Sensory Neuropathy, See [[Hereditary Motor Sensory Neuropathy]]

[[MRSA]]

MS, See [[Multiple Sclerosis]]

[[Multiple Sclerosis]]

[[Muscular Dystrophy]]

[[Muscular Dystrophy Carrier]]

[[Myalgic Encephalomyelitis]]

[[Myasthenia Gravis]]

[[Myelodysplasia]]

Myelofibrosis, See [[Myeloproliferative Neoplasm]]

[[Myeloproliferative Neoplasm]]

[[Myocarditis]]

Myoclonus, See [[Central Nervous System Disease]]

[[Myositis]]

Myotonia Congenita, See [[Muscular Dystrophy]]

Myotonic Dystrophy, See [[Muscular Dystrophy]]

Myxoedema, See [[Thyroid Disease]]

[[Myxoma]]

==N==

[[Narcolepsy]]

[[Needle Phobia]]

Needlestick Injury, See [[Innoculation Injury]]

Neotigason, See [[Acne]]

Nephrectomy (Kidney Removal), See [[Kidney, Single]]

Nephritis, See [[Kidney Disease]]

Nephropathy, See [[Kidney Disease]]

Nephrotic Syndrome, See [[Kidney Disease]]

[[Neurofibromatosis]]

Neuroma, See [[Brain Tumour]]

[[Neurosurgery]]

[[Neutropenia]]

[[Non Steroidal Anti-Inflammatory Drug]]

Non-Hodgkin Lymphoma, See [[Malignancy]]

Nose Bleed, See [[Epistaxis]]

NSAID, See [[Non Steroidal Anti-Inflammatory Drug]]

==O==

Obesity, See [[Weight]]

[[Obsessive Compulsive Disorder]]

[[Obstetric Cholestasis]]

[[Obstructive Sleep Apnoea]]

[[Ocular Surgery]]

[[Ocular Tissue Recipient]]

Oesophagitis, See [[Gastro-Oesophageal Reflux]]

[[Onchocerciasis]]

Operation, See [[Surgery]]

[[Optic Neuritis]]

[[Osgood Schlatter Disease]]

Osler-Weber-Rendu Disease, See [[Hereditary Haemorrhagic Telangiectasia]]

[[Osteoarthritis]]

[[Osteochondroma]]

Osteodystrophia Deformans, See [[Paget Disease]]

[[Osteogenesis Imperfecta]]

Osteoma, See [[Osteochondroma]]

[[Osteomalacia]]

[[Osteomyelitis]]

[[Osteopenia]]

[[Osteoporosis]]

[[Otosclerosis]]

[[Ovarian Cyst]]

==P==

Pacemaker, See [[Heart, Arrhythmia]]

[[Paget Disease]]

Paget Disease Of The Nipple, See [[Malignancy]]

[[Palindromic Rheumatism]]

[[Pancreatitis]]

Panic Attacks, See Anxiety Disorder

Paraplegia, See [[Disabled Volunteer]]

Paraprotein, See [[Monoclonal Gammopathy]]

[[Paratyphoid Fever]]

Parkinson Disease, See [[Central Nervous System Disease]]

[[Parvovirus]]

Patent Ductus Arteriosus, See [[Heart, Congenital Defect]]

Patent Foramen Ovale, See [[Heart, Congenital Defect]]

[[Pelvic Inflammatory Disease]]

[[Pemphigoid]]

[[Pemphigus]]

[[Peptic Ulcer]]

[[Pericarditis]]

[[Peripheral Neuropathy]]

[[Peripheral Vascular Disease]]

[[Peritonitis]]

[[Pernicious Anaemia]]

Peroneal Muscular Atrophy, See [[Hereditary Motor Sensory Neuropathy]]

[[Perthes Disease]]

[[Peyronie Disease]]

Phaeochromocytoma, See [[Malignancy]]

[[Phenylketonuria]]

[[Phlebitis]]

[[Pilonidal Sinus]]

[[Pituitary Adenoma]]

[[Pityriasis]]

[[Pleural Effusion]]

[[Pleurisy]]

[[Pneumonia]]

[[Pneumothorax]]

Polio, See [[Disabled Volunteer]]

Polyarteritis Nodosa, See [[Vasculitis]]

[[Polycystic Kidney Disease]]

[[Polycystic Ovarian Syndrome]]

[[Polycythaemia]]

Polycythemia Rubra Vera, See [[Myeloproliferative Neoplasm]]

[[Polymyalgia]]

[[Porphyria (All Types)]]

Positive Cervical Smear, See [[Cervical Carcinoma In-Situ]]

Post-Viral Fatigue Syndrome, See [[Myalgic Encephalomyelitis]]

[[POTS (Postural Orthostatic Tachycardia Syndrome)]]

[[Pre-Cancerous Cells]]

[[Pre-Eclampsia]]

[[Pregnancy]]

[[Prion-Associated Disease]]

[[Proctitis]]

[[Prolactinoma]]

Prolapsed Disc, See [[Back Conditions]]

[[Prostate, Enlarged]]

Prostatism, See [[Benign Prostatic Hyperplasia]]

Protein C Deficiency, See [[Thrombophilia]]

Protein S Deficiency, See [[Thrombophilia]]

Prothrombin Gene Mutation, See [[Thrombophilia]]

[[Psoriasis]]

Psoriatic Arthritis, See [[Psoriasis]]

Pulmonary Embolus, See [[Thrombosis]]

Pulmonary Stenosis / Regurgitation, See [[Heart, Congenital Defect]]

Pulmonary Valvotomy, See [[Heart, Valve Disease]]

[[Purpura]]

Pyelonephritis, See [[Kidney Disease]]

[[Pyloric Stenosis]]

[[Pyruvate Kinase Deficiency]]

==Q==

[[Q Fever]]

==R==

[[Rabies]]

[[Radionuclide Therapy]]

[[Radiotherapy]]

[[Raynaud Disease]]

[[Reactive Arthritis]]

[[Reflex Sympathetic Dystrophy]]

Reflux, See [[Gastro-Oesophageal Reflux]]

Reiter Syndrome, See [[Reactive Arthritis]]

Renal Colic, See [[Kidney Disease]]

Renal Disease, See [[Kidney Disease]]

[[Restless Legs Syndrome]]

[[Retinitis Pigmentosa]]

[[Retinoic Acid Derivatives]]

[[Reye Syndrome]]

[[Rheumatic Fever]]

[[Rheumatoid Arthritis]]

[[Rhinitis]]

Ricketts, See [[Disabled Volunteer]]

[[Rickettsial Infection]]

Right Bundle Branch Block, See [[Heart, Arrhythmia]]

[[Ringworm]]

River Blindness, See [[Onchocerciasis]]

Roaccutane, See [[Acne]]

Rocky Mountain Spotted Fever, See [[Rickettsial Infection]]

Rodent Ulcer, See [[Basal Cell Carcinoma]]

[[Rosacea]]

==S==

Sacroiliac Joint Problems, See [[Back Conditions]]

Sandhoff Disease, See [[Inherited Disease]]

[[Sarcoidosis]]

[[Scarlet Fever]]

Scheuermann Disease, See [[Back Conditions]]

[[Schistosomiasis]]

Schwannoma, See [[Acoustic Neuroma]]

Sciatica, See [[Back Conditions]]

[[Scleroderma]]

Scoliosis, See [[Back Conditions]]

[[Sebaceous Cyst]]

[[Seborrhoeic Dermatitis]]

Seizures, See [[Epilepsy]]

[[Septicaemia]]

Sex Change, See [[Gender Reassignment]]

[[Sexual Orientation]]

[[Sexually Transmitted Diseases]]

Shingles, See [[Chicken Pox]]

Shwachman-Diamond Syndrome, See [[Inherited Disease]]

[[Sickle Cell Disease]]

[[Sickle Cell Trait]]

[[Simple Cyst]]

[[Situs Inversus]]

[[Sjogren’s Syndrome]]

Sleeping Sickness, See [[African Trypanosomiasis]]

Smear - Abnormal Cervical, See [[Cervical Carcinoma In-Situ]]

[[South American Trypanosomiasis]]

Spasmodic Torticollis, See [[Back Conditions]]

Spherocytosis, See [[Hereditary Spherocytosis]]

[[Spina Bifida]]

Spinal Fusion, See [[Back Conditions]]

Spinal Muscular Atrophy, See [[Inherited Disease]]

Spinal Stenosis, See [[Back Conditions]]

[[Spitz Naevus]]

[[Splenectomy]]

Spondylolisthesis, See [[Back Conditions]]

Spondylosis, See [[Back Conditions]]

Spot Baldness, See [[Alopecia Areata]]

Spots, See [[Acne]]

[[Steroid Treatment]]

[[Stevens-Johnson Syndrome]]

Stickler Syndrome, See [[Inherited Disease]]

[[Still Disease]]

[[Stroke]]

[[Subarachnoid Haemorrhage]]

[[Subdural Haematoma]]

[[Subglottic Stenosis]]

Superficial Thrombophlebitis, See [[Thrombosis]]

Supraventricular Tachycardia, See [[Heart, Arrhythmia]]

[[Surgery]]

[[Suxamethonium Allergy]]

Sydenham Chorea, See [[Rheumatic Fever]]

[[Syphilis]]

[[Syringomyelia]]

[[Systemic Lupus Erythematosus]]

==T==

Tachycardia, See [[Heart, Arrhythmia]]

Takayasu Arteritis, See [[Vasculitis]]

Tattoo, See [[Body Piercing]]

Tay Sachs Disease, See [[Inherited Disease]]

Temporal Arteritis, See [[Vasculitis]]

Temporal Lobectomy, See [[Neurosurgery]] and [[Epilepsy]]

Termination Of Pregnancy, See [[Pregnancy]] and [[Surgery]]

Testosterone Injections, See [[Hormone Replacement Therapy]] and [[Addiction and Drug Abuse]]

Tetralogy Of Fallot, See [[Heart, Congenital Defect]]

Tetraplegia, See [[Disabled Volunteer]]

Thalassaemia Major, See [[Haemoglobin Disorder]]

Thalassaemia Trait (Minor), See [[Haemoglobin Disorder]]

[[Thoracic Outlet Syndrome]]

Thrombocythemia, See [[Thrombocytosis]]

[[Thrombocytopenia]]

[[Thrombocytosis]]

[[Thrombophilia]]

Thrombophlebitis, See [[Thrombosis]]

[[Thrombosis]]

Thrush, See [[Candida Infection]]

[[Thyroid Disease]]

Thyrotoxicosis, See [[Thyroid Disease]]

Tick Typhus, See [[Rickettsial Infection]]

[[Tissue Or Organ Transplant]]

[[Toxoplasmosis]]

[[Transfusion]]

Transient Ischaemic Attack (TIA), See [[Stroke]]

[[Transsexual]]

Treacher-Collins Syndrome, See [[Inherited Disease]]

Trial, See [[Clinical Trial]]

Tricuspid Regurgitation, See [[Heart, Valve Disease]]

Tricuspid Stenosis, See [[Heart, Valve Disease]]

[[Trigeminal Neuralgia]]

Trypanosoma Cruzi Infection, See [[South American Trypanosomiasis]]

[[Tuberculosis]]

[[Turner Syndrome]]

[[Typhoid]]

==U==

Ulcerative Colitis, See [[Inflammatory Bowel Disease]]

[[Urticaria]]

Uterine Fibroid, See [[Fibroids]]

Uveitis, See [[Eye Disease]]

==V==

Vaccine, See [[Immunisation]]

Vaccination, See [[Immunisation]]

Varicella Zoster, See [[Chicken Pox]]

[[Varicose Veins]]

[[Vasculitis]]

[[Vasovagal Attack]]

[[Venesection]]

Ventricular Septal Defect, See [[Heart, Congenital Defect]]

Vestibular Schwannoma, See [[Acoustic Neuroma]]

Visceral Leishmaniasis, See [[Leishmaniasis]]

[[Vitiligo]]

Von Recklinghausen Disease, See [[Neurofibromatosis]]

Von Willebrand Disease, See [[Bleeding Disorder]]

==W==

Warts, See [[Human Papilloma Virus]]

Wegener Granulomatosis, See [[Vasculitis]]

[[Weight]]

Weil Disease, See [[Leptospirosis]]

Werdnig-Hoffmann Disease, See [[Inherited Disease]]

[[West Nile Virus]]

[[Wilson Disease]]

Wolff-Parkinson-White Syndrome, See [[Heart, Arrhythmia]]

==X==

==Y==

[[Yaws]]

Yellow Fever, See [[Infection, Acute]]

Yellow Fever Vaccine, See [[Immunisation]]

==Z==

=Appendix 1 - Haematologic and biochemical testing at donor medical=

'''The following haematological and biochemical tests are performed at the donor medical:'''

Full blood count

Urea and Electrolytes

Liver function tests

Bone function tests

Cholesterol

Random glucose

Coagulation screen (PT, APTT and fibrinogen)

ABO and Rh blood grouping

Pregnancy test (B-HCG), if relevant

=Appendix 2 - Infectious disease marker testing at ET/CT and donor medical=

'''The following infectious disease markers are tested for all donors at the donor medical:'''

HIV (P24 antigen and antibody)

Hepatitis B (surface antigen and core antibody)

Hepatitis C (antibody and RNA)

HTLV I+II (antibody)

Syphilis (antibody)

Toxoplama (antibody)

EBV (VCA/NA IgG)

CMV (IgG)

Varicella (IgG)

'''The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:'''

Malarial antigen/antibodies

T.cruzi (Chagas disease) antibodies

West nile virus NAT

=Appendix 3 - Other investigations at donor medical=

=Appendix 4 - Special consideration for donors in the Armed Forces=

'''Guidance for Armed Forces donors'''

It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.

As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.

Hypertension

2012-10-08T13:17:08Z

Dr Robert Lown: added description of stage 2 hypertension

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
High blood pressure.

==Guidance==
===Acceptable===

Controlled with medication.

===Unacceptable===

Hypertension is under investigation;

Medication has been commenced or changed within the last four weeks;

Donor is feeling faint or giddy from medication;

There is evidence of heart failure or renal failure;

A threshold of 150/95 is set at donor workup, which equates to stage 2 hypertension. Above this leve the donor should be deferred and the hypertension investigated. High blood pressure readings at work-up should be repeated at least twice on the same occasion.

If a donor has persistently raised readings, this should be repeated on a separate occasion by a GP or other healthcare professional. If the blood pressure is then found to be within acceptable limits, the donor may be cleared to donate. Otherwise they should be temporarily deferred until the hypertension has been managed and treatment instigated if necessary.

==Pseudonyms or Related Conditions==
High blood pressure
Blood pressure

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Arachnoid Cyst

2012-09-17T10:31:59Z

Dr Robert Lown: /* Explanation of Condition */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
Benign fluid-filled swelling (cyst) in the brain. Rarely causes symptoms.

See also [http://http://en.wikipedia.org/wiki/Arachnoid_cyst Arachnoid Cyst]

==Guidance==
Accept if asymptomatic and no secondary hydrocephalus.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
17th September 2012

Arachnoid Cyst

2012-09-17T10:31:41Z

Dr Robert Lown: Page created

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
Benign fluid-filled swelling (cyst) in the brain. Rarely causes symptom.

See also [http://http://en.wikipedia.org/wiki/Arachnoid_cyst Arachnoid Cyst]

==Guidance==
Accept if asymptomatic and no secondary hydrocephalus.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
17th September 2012