Anthony Nolan Medical Guidelines - User contributions [en]

PrEP

2019-12-17T15:11:30Z

JoseRosSoto:

PrEP

2019-12-17T15:07:54Z

JoseRosSoto: /* Explanation of Condition */

BRAIN BLEED

2019-09-26T14:11:49Z

JoseRosSoto:

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
NOT ACCEPTABLE

==Individual at Risk==
Donor

==Explanation of Condition==
Bleeding involving the brain, usually caused by trauma to the head.

==Guidance==
Unacceptable due to high risk of recurrent bleeding. Outcome can be minimal neurological damage to serious ongoing mental changes.

==Pseudonyms or Related Conditions==
Intracraneal haemorrhage

Epidural haematoma

Sudural haematoma

Subarachnoid haematoma

BRAIN BLEED

2019-09-26T14:11:14Z

JoseRosSoto: Created page with "==Acceptability at Recruitment== NOT ACCEPTABLE ==Acceptability at CT / Work-Up== NOT ACCEPTABLE ==Individual at Risk== Donor ==Explanation of Condition== Bleeding involvin..."

Malaria

2019-09-11T11:42:58Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return, accept.

A test for malaria antibody will be performed at medical.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

A test for malaria antibody will be performed at medical.

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, accept.

A test for malaria antibody will be performed at medical.

'''d) For all other donors:'''

-If at least four months and less than 12 months have passed since return from a malaria endemic area, accept.

-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.

-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Malaria

2019-06-17T09:02:39Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return, accept.

A test for malaria antibody will be performed at medical.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

A test for malaria antibody will be performed at medical.

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, accept.

A test for malaria antibody will be performed at medical.

'''d) For all other donors:'''
-If at least four months and less than 12 months have passed since return from a malaria endemic area, accept.
-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Retinal detachment

2019-06-12T14:50:11Z

JoseRosSoto: Created page with "==Acceptability at Recruitment== QUALIFIED ==Acceptability at CT / Work-Up== QUALIFIED ==Individual at Risk== Donor ==Explanation of Condition== A detached retina is when..."

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
A detached retina is when the thin layer at the back of your eye (retina) becomes loose. It needs to be treated quickly to stop it permanently affecting your sight.

There is a theoretical risk of impact of filgrastim on the small blood vessels of the eyes especially the retina, but data is very limited and there are no cases reported in healthy stem cell donors.

==Guidance==

Donors with a history of retinal disorders or detachment should be deemed for marrow-only, unless a recent ophthalmologic evaluation has ruled out any abnormalities.

Malaria

2019-06-12T14:39:53Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return, accept.

A test for malaria antibody will be performed at medical.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

A test for malaria antibody will be performed at medical.

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, accept.

'''d) For all other donors:'''
-If at least four months and less than 12 months have passed since return from a malaria endemic area, accept.
-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Malaria

2019-06-12T14:39:15Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return, accept.

A test for malaria antibody will be performed at medical.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

A test for malaria antibody will be performed at medical.

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, accept.

'''d) For all other donors:'''
-If at least four months and less than 12 months have passed since return from a malaria endemic area, accept.
-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Hepatitis B

2019-06-12T14:21:43Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Viral liver infection transmitted through contact with blood or other body fluids, most commonly transmitted through sex, from mother to child, or through contaminated blood products or needles.

==Guidance==

Discuss each case with medical officer.

===Current Infection===
Unacceptable if current active infection (HbSAg positive or HBV DNA positive).

===Infected Current Sexual Partner===
Acceptable if evidence of past resolved infection or immunity from vaccination:

Donor is hep B surface antibody positive and hep B surface antigen negative

Core Ab antibody may also be positive if resolved infection

HepB PCR negative (performed at medical)

===Past Infection===
May donate if:

More than 12 months from recovery of acute infection

All serological antigen markers (HBsAntigen, HBeAntigen) are negative and HB core antibody is positive.

PCR test (performed at medical) should be negative.

Inform TC, donor and donor's GP.

===Former Sexual Partner===
A former sexual partner of an infected individual may donate from four months after last sexual contact if either:

All serological markers are negative

OR

positive HB core antibody, positive Hep B surface antibody and all antigen markers negative.

Inform transplant centre of all potential exposures.

Four month deferral may be shortened at discretion of transplant centre

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 2

====Date of Last Update====
1 June 2016

Hepatitis B

2019-06-12T14:20:47Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Viral liver infection transmitted through contact with blood or other body fluids, most commonly transmitted through sex, from mother to child, or through contaminated blood products or needles.

==Guidance==

Discuss each case with medical officer.

===Current Infection===
Unacceptable if current active infection (HbSAg positive or HBV DNA positive).

===Infected Current Sexual Partner===
Acceptable if evidence of past resolved infection or immunity from vaccination:

Donor is hep B surface antibody positive and hep B surface antigen negative

Core Ab antibody may also be positive if resolved infection

HepB PCR negative (performed at medical)

===Past Infection===
May donate if:

More than 12 months from recovery of acute infection

All serological antigen markers (HBsAntigen, HBeAntigen) are negative and HB core antibody is positive.

PCR test (performed at medical) should be negative.

Inform TC as soon as past infection identified

===Former Sexual Partner===
A former sexual partner of an infected individual may donate from four months after last sexual contact if either:

All serological markers are negative

OR

positive HB core antibody, positive Hep B surface antibody and all antigen markers negative.

Inform transplant centre of all potential exposures.

Four month deferral may be shortened at discretion of transplant centre

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 2

====Date of Last Update====
1 June 2016

PrEP

2019-04-18T13:17:01Z

JoseRosSoto: /* Justification for guidance */

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
Acceptable BUT inform donors that they should be off PrEP for 3 months to proceed at VT

==Acceptability at CT / Work-Up==
Acceptable if donor has been off PrEP for at least 3 months + there is low sexual risk behaviour.

Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour.

PrEP protects from HIV infection but do not protect against other STDs (sexual transmission diseases) such as gonorrhoea or syphilis. If one of these microorganisms is passed on to an immune-compromised patient, it can be life-threatening. Therefore we have a conservative approach.

PrEP

2019-04-18T13:12:25Z

JoseRosSoto: /* Acceptability at CT / Work-Up */

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
Acceptable BUT inform donors that they should be off PrEP for 3 months to proceed at VT

==Acceptability at CT / Work-Up==
Acceptable if donor has been off PrEP for at least 3 months + there is low sexual risk behaviour.

Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour:
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.

PrEP

2019-04-18T13:12:08Z

JoseRosSoto: /* Acceptability at Recruitment */

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
Acceptable BUT inform donors that they should be off PrEP for 3 months to proceed at VT

==Acceptability at CT / Work-Up==
Acceptable if donor has been off PrEP for at least 3 months + low sexual risk behaviour.

Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour:
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.

Back Conditions

2019-04-18T13:09:55Z

JoseRosSoto: /* Scoliosis */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==General Guidance==

In general, donors undergoing a bone marrow collection run the risk of exacerbating pre-existing mechanical back conditions due to the shearing forces applied to the lower back and pelvis during the procedure. However, many such donors may donate by PBSC.

===Defer in the following cases===

Donors with non-mechanical inflammatory back conditions (eg associated with autoimmune disease)

Any donor receiving regular steroid injections to the spine

Any donor with a back condition which may physically prohibit the donor transferring to an apheresis couch, or lying in an apheresis couch for at least four hours (venous access is not permitted in a wheelchair), or a back condition which might compromise the safety of the donor or staff during collection

==Individual Guidance==

Back complaints should be considered in the subgroups below

==Mild, occasional episodes related to exertion (incl sciatica). Minimal impact on activities of daily living and occasional use of medication==

'''Recruitment''' - Accept

'''VT''' - Accept for PBSC only. Can consider BMH on case-by-case basis following discussion with MO.

==Severe chronic back pain. Impacts on activities of daily living==

'''Recruitment''' - Defer

'''VT''' - Defer

==History of current or past herniated intevertebral disc==

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC only

==History of back surgery==

Defer if less than 4 months from date of surgery.

Donor must be fully recovered from [[surgery]]

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC Only

==Scoliosis==
Discuss case-by-case with MO.

'''Recruitment''' - If previous surgery and now asymptomatic allow donation for PBSC only.

'''VT''' - If previous surgery and now asymptomatic allow donation for PBSC only.

==History of fracture, dislocation or instability==

'''Recruitment''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

'''VT''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

==Version==
Version 2, Edition 1

====Date of Last Update====
9 June 2016

Back Conditions

2019-04-18T13:09:44Z

JoseRosSoto: /* Scoliosis */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==General Guidance==

In general, donors undergoing a bone marrow collection run the risk of exacerbating pre-existing mechanical back conditions due to the shearing forces applied to the lower back and pelvis during the procedure. However, many such donors may donate by PBSC.

===Defer in the following cases===

Donors with non-mechanical inflammatory back conditions (eg associated with autoimmune disease)

Any donor receiving regular steroid injections to the spine

Any donor with a back condition which may physically prohibit the donor transferring to an apheresis couch, or lying in an apheresis couch for at least four hours (venous access is not permitted in a wheelchair), or a back condition which might compromise the safety of the donor or staff during collection

==Individual Guidance==

Back complaints should be considered in the subgroups below

==Mild, occasional episodes related to exertion (incl sciatica). Minimal impact on activities of daily living and occasional use of medication==

'''Recruitment''' - Accept

'''VT''' - Accept for PBSC only. Can consider BMH on case-by-case basis following discussion with MO.

==Severe chronic back pain. Impacts on activities of daily living==

'''Recruitment''' - Defer

'''VT''' - Defer

==History of current or past herniated intevertebral disc==

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC only

==History of back surgery==

Defer if less than 4 months from date of surgery.

Donor must be fully recovered from [[surgery]]

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC Only

==Scoliosis==
Discuss case-by-case with MO.

'''Recruitment''' - if previous surgery and now asymptomatic allow donation for PBSC only.

'''VT''' - If previous surgery and now asymptomatic allow donation for PBSC only.

==History of fracture, dislocation or instability==

'''Recruitment''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

'''VT''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

==Version==
Version 2, Edition 1

====Date of Last Update====
9 June 2016

PrEP

2019-03-29T16:32:32Z

JoseRosSoto:

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
ACCEPTABLE but inform donors that they should be off PrEP for 3 months before VT

==Acceptability at CT / Work-Up==
Acceptable if donor has been off PrEP for at least 3 months + low sexual risk behaviour.

Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour:
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.

Back Conditions

2019-03-29T16:29:29Z

JoseRosSoto: /* Scoliosis */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==General Guidance==

In general, donors undergoing a bone marrow collection run the risk of exacerbating pre-existing mechanical back conditions due to the shearing forces applied to the lower back and pelvis during the procedure. However, many such donors may donate by PBSC.

===Defer in the following cases===

Donors with non-mechanical inflammatory back conditions (eg associated with autoimmune disease)

Any donor receiving regular steroid injections to the spine

Any donor with a back condition which may physically prohibit the donor transferring to an apheresis couch, or lying in an apheresis couch for at least four hours (venous access is not permitted in a wheelchair), or a back condition which might compromise the safety of the donor or staff during collection

==Individual Guidance==

Back complaints should be considered in the subgroups below

==Mild, occasional episodes related to exertion (incl sciatica). Minimal impact on activities of daily living and occasional use of medication==

'''Recruitment''' - Accept

'''VT''' - Accept for PBSC only. Can consider BMH on case-by-case basis following discussion with MO.

==Severe chronic back pain. Impacts on activities of daily living==

'''Recruitment''' - Defer

'''VT''' - Defer

==History of current or past herniated intevertebral disc==

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC only

==History of back surgery==

Defer if less than 4 months from date of surgery.

Donor must be fully recovered from [[surgery]]

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC Only

==Scoliosis==
Discuss case-by-case with MO.

'''Recruitment''' - Accept if asymptomatic/no impact on daily activities, even if previous surgery in the upper back.

'''VT''' - Accept if asymptomatic/no impact on daily activities, even if previous surgery in the upper back.

==History of fracture, dislocation or instability==

'''Recruitment''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

'''VT''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

==Version==
Version 2, Edition 1

====Date of Last Update====
9 June 2016

Back Conditions

2019-03-29T16:29:14Z

JoseRosSoto: /* Scoliosis */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==General Guidance==

In general, donors undergoing a bone marrow collection run the risk of exacerbating pre-existing mechanical back conditions due to the shearing forces applied to the lower back and pelvis during the procedure. However, many such donors may donate by PBSC.

===Defer in the following cases===

Donors with non-mechanical inflammatory back conditions (eg associated with autoimmune disease)

Any donor receiving regular steroid injections to the spine

Any donor with a back condition which may physically prohibit the donor transferring to an apheresis couch, or lying in an apheresis couch for at least four hours (venous access is not permitted in a wheelchair), or a back condition which might compromise the safety of the donor or staff during collection

==Individual Guidance==

Back complaints should be considered in the subgroups below

==Mild, occasional episodes related to exertion (incl sciatica). Minimal impact on activities of daily living and occasional use of medication==

'''Recruitment''' - Accept

'''VT''' - Accept for PBSC only. Can consider BMH on case-by-case basis following discussion with MO.

==Severe chronic back pain. Impacts on activities of daily living==

'''Recruitment''' - Defer

'''VT''' - Defer

==History of current or past herniated intevertebral disc==

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC only

==History of back surgery==

Defer if less than 4 months from date of surgery.

Donor must be fully recovered from [[surgery]]

'''Recruitment''' - Accept for PBSC only

'''VT''' - Accept for PBSC Only

==Scoliosis==
Discuss with MO case-by-case.

'''Recruitment''' - Accept if asymptomatic/no impact on daily activities, even if previous surgery in the upper back.

'''VT''' - Accept if asymptomatic/no impact on daily activities, even if previous surgery in the upper back.

==History of fracture, dislocation or instability==

'''Recruitment''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

'''VT''' - Accept for PBSC only provided does not meet criteria for severe chronic back pain

==Version==
Version 2, Edition 1

====Date of Last Update====
9 June 2016

Lichen Sclerosus

2019-03-29T16:24:07Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED - see below

==Acceptability at CT / Work-Up==
QUALIFIED - see below

==Individual at Risk==
Recipient

==Explanation of Condition==
White thickening of the skin typically affecting the genital area in both men and women. It can flare up requiring mainly topical treatment.

See also [http://http://en.wikipedia.org/wiki/Lichen_sclerosus Lichen Sclerosus]

==Guidance==

Acceptable if on topical steroids (management similar to eczema)

Discuss case-by-case with MO as decision depends on clinical severity.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Lichen Sclerosus

2019-03-29T16:23:36Z

JoseRosSoto:

==Acceptability at Recruitment==
QUALIFIED - see below

==Acceptability at CT / Work-Up==
QUALIFIED - see below

==Individual at Risk==
Recipient

==Explanation of Condition==
White thickening of the skin typically affecting the genital area in both men and women. It can flare up requiring mainly topical treatment.

See also [http://http://en.wikipedia.org/wiki/Lichen_sclerosus Lichen Sclerosus]

==Guidance==

Acceptable if on topical steroids (management similar to eczema)

Discuss case-by-case with MO.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

PrEP

2018-12-20T16:22:06Z

JoseRosSoto: /* Acceptability at CT / Work-Up */

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
Acceptable if donor has been off PrEP for at least 3 months + low sexual risk behaviour.

Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour:
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.

PrEP

2018-12-20T16:21:45Z

JoseRosSoto:

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
Acceptable if the donor has been off PrEP for at least 3 months + low sexual risk behaviour.

Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour:
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.

PrEP

2018-12-20T16:20:52Z

JoseRosSoto:

PrEP – Pre-Exposure Prophylaxis

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
Acceptable if the donor has been off PrEP for at least 3 months + low sexual behaviour risk.
Otherwise postpone.

==Individual at Risk==
Recipient

==Explanation of Condition==
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).

==Justification for guidance==
Similar to High Risk Sexual Behaviour:
With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.

High Risk Sexual Behaviour

2018-09-26T10:01:00Z

JoseRosSoto: /* Guidance at VT/WORK-UP */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor themselves currently participate in high-risk behaviour, or currently have sex with someone from a high-risk background. Importantly we rely on donors to assess their own individual risk.

The aim is to reduce the risk of 'window period' transmissions, where a donor is infected with (for example) HIV, but the infection is too recent to be picked up by our screening tests and the infection is passed to the patient. For this reason, donors who have participated in high risk sexual behaviour say over one year ago, but do not do so currently, should be allowed to donate.

There is no strict definition of what high-risk behaviour/background is, but it would include those who have unprotected vaginal or anal sex with multiple partners (with a higher risk in men who have sex with men, or MSM), those who pay (or are paid) for sex, those from an geographical area with a very high prevalence of HIV and those with other sexually transmitted diseases.

Unprotected sex within a monogamous relationship is not necessarily seen as high-risk behaviour, regardless of whether it is a same-sex relationship.

==Guidance at RECRUITMENT==

UNACCEPTABLE

==Guidance at VT/WORK-UP==

TEMPORARY DEFERRAL

- Someone who has had sex for money or drugs --> defer for 3 months

- Sex with a high risk partner (ie with HIV, HBV, HCV, syphilis, HTLV, person who has received money or drugs for sex, person who has injected or been injected with non- medically prescribed drugs) -> defer for 3 months

- Sex with a partner who has been sexually active in areas where HIV is common --> defer for 3 months

- There is no deferral for men who had sex with men

*QUESTIONNAIRE:

1) Long-term partner/multiple partners?

2) Protected sex?

3) Via: Vaginal / anal / oral

4) Partner/s: From high-prevalence HIV area? On IV drugs?

5) Paid for sex?

6) Time from the last sexual encounter

==Justification for guidance==

With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample oppotunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation with vastly outweigh the risk of transmission of an infectious agent.

For these reasons, the employment of fixed deferral periods for certain groups deemed to be at a higher risk of developing window period infection, particularly men who have had sex with men, is not recommended.

==Version==
Version 1, Edition 3

====Date of Last Update====
1 June 2016

High Risk Sexual Behaviour

2018-09-26T10:00:24Z

JoseRosSoto: /* Guidance at VT/WORK-UP */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor themselves currently participate in high-risk behaviour, or currently have sex with someone from a high-risk background. Importantly we rely on donors to assess their own individual risk.

The aim is to reduce the risk of 'window period' transmissions, where a donor is infected with (for example) HIV, but the infection is too recent to be picked up by our screening tests and the infection is passed to the patient. For this reason, donors who have participated in high risk sexual behaviour say over one year ago, but do not do so currently, should be allowed to donate.

There is no strict definition of what high-risk behaviour/background is, but it would include those who have unprotected vaginal or anal sex with multiple partners (with a higher risk in men who have sex with men, or MSM), those who pay (or are paid) for sex, those from an geographical area with a very high prevalence of HIV and those with other sexually transmitted diseases.

Unprotected sex within a monogamous relationship is not necessarily seen as high-risk behaviour, regardless of whether it is a same-sex relationship.

==Guidance at RECRUITMENT==

UNACCEPTABLE

==Guidance at VT/WORK-UP==

TEMPORARY DEFERRAL

- Someone who has had sex for money or drugs --> defer for 3 months

- Sex with a high risk partner (ie with HIV, HBV, HCV, syphilis, HTLV, person who has received money or drugs for sex, person who has injected or been injected with non- medically prescribed drugs) -> defer for 3 months

- Sex with a partner who has been sexually active in areas where HIV is common --> defer for 3 months

- There is no deferral for men who had sex with men

*QUESTIONNAIRE:

1) Duration: Long-term partner/multiple partners

2) Protected sex?

3) Via: Vaginal / anal / oral

4) Partner/s: From high-prevalence HIV area? On IV drugs?

5) Paid for sex?

6) Time from the last sexual encounter

==Justification for guidance==

With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample oppotunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation with vastly outweigh the risk of transmission of an infectious agent.

For these reasons, the employment of fixed deferral periods for certain groups deemed to be at a higher risk of developing window period infection, particularly men who have had sex with men, is not recommended.

==Version==
Version 1, Edition 3

====Date of Last Update====
1 June 2016

High Risk Sexual Behaviour

2018-09-26T10:00:11Z

JoseRosSoto: /* Guidance at VT/WORK-UP */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor themselves currently participate in high-risk behaviour, or currently have sex with someone from a high-risk background. Importantly we rely on donors to assess their own individual risk.

The aim is to reduce the risk of 'window period' transmissions, where a donor is infected with (for example) HIV, but the infection is too recent to be picked up by our screening tests and the infection is passed to the patient. For this reason, donors who have participated in high risk sexual behaviour say over one year ago, but do not do so currently, should be allowed to donate.

There is no strict definition of what high-risk behaviour/background is, but it would include those who have unprotected vaginal or anal sex with multiple partners (with a higher risk in men who have sex with men, or MSM), those who pay (or are paid) for sex, those from an geographical area with a very high prevalence of HIV and those with other sexually transmitted diseases.

Unprotected sex within a monogamous relationship is not necessarily seen as high-risk behaviour, regardless of whether it is a same-sex relationship.

==Guidance at RECRUITMENT==

UNACCEPTABLE

==Guidance at VT/WORK-UP==

TEMPORARY DEFERRAL

- Someone who has had sex for money or drugs --> defer for 3 months

- Sex with a high risk partner (ie with HIV, HBV, HCV, syphilis, HTLV, person who has received money or drugs for sex, person who has injected or been injected with non- medically prescribed drugs) -> defer for 3 months

- Sex with a partner who has been sexually active in areas where HIV is common --> defer for 3 months

- There is no deferral for men who had sex with men

=QUESTIONNAIRE:

1) Duration: Long-term partner/multiple partners

2) Protected sex?

3) Via: Vaginal / anal / oral

4) Partner/s: From high-prevalence HIV area? On IV drugs?

5) Paid for sex?

6) Time from the last sexual encounter

==Justification for guidance==

With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample oppotunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation with vastly outweigh the risk of transmission of an infectious agent.

For these reasons, the employment of fixed deferral periods for certain groups deemed to be at a higher risk of developing window period infection, particularly men who have had sex with men, is not recommended.

==Version==
Version 1, Edition 3

====Date of Last Update====
1 June 2016

High Risk Sexual Behaviour

2018-09-26T09:59:54Z

JoseRosSoto: /* Guidance at VT/WORK-UP */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor themselves currently participate in high-risk behaviour, or currently have sex with someone from a high-risk background. Importantly we rely on donors to assess their own individual risk.

The aim is to reduce the risk of 'window period' transmissions, where a donor is infected with (for example) HIV, but the infection is too recent to be picked up by our screening tests and the infection is passed to the patient. For this reason, donors who have participated in high risk sexual behaviour say over one year ago, but do not do so currently, should be allowed to donate.

There is no strict definition of what high-risk behaviour/background is, but it would include those who have unprotected vaginal or anal sex with multiple partners (with a higher risk in men who have sex with men, or MSM), those who pay (or are paid) for sex, those from an geographical area with a very high prevalence of HIV and those with other sexually transmitted diseases.

Unprotected sex within a monogamous relationship is not necessarily seen as high-risk behaviour, regardless of whether it is a same-sex relationship.

==Guidance at RECRUITMENT==

UNACCEPTABLE

==Guidance at VT/WORK-UP==

TEMPORARY DEFERRAL

- Someone who has had sex for money or drugs --> defer for 3 months

- Sex with a high risk partner (ie with HIV, HBV, HCV, syphilis, HTLV, person who has received money or drugs for sex, person who has injected or been injected with non- medically prescribed drugs) -> defer for 3 months

- Sex with a partner who has been sexually active in areas where HIV is common --> defer for 3 months

- There is no deferral for men who had sex with men

QUESTIONNAIRE:

1) Duration: Long-term partner/multiple partners

2) Protected sex?

3) Via: Vaginal / anal / oral

4) Partner/s: From high-prevalence HIV area? On IV drugs?

5) Paid for sex?

6) Time from the last sexual encounter

==Justification for guidance==

With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample oppotunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation with vastly outweigh the risk of transmission of an infectious agent.

For these reasons, the employment of fixed deferral periods for certain groups deemed to be at a higher risk of developing window period infection, particularly men who have had sex with men, is not recommended.

==Version==
Version 1, Edition 3

====Date of Last Update====
1 June 2016

High Risk Sexual Behaviour

2018-09-26T09:59:24Z

JoseRosSoto: /* Guidance at VT/WORK-UP */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor themselves currently participate in high-risk behaviour, or currently have sex with someone from a high-risk background. Importantly we rely on donors to assess their own individual risk.

The aim is to reduce the risk of 'window period' transmissions, where a donor is infected with (for example) HIV, but the infection is too recent to be picked up by our screening tests and the infection is passed to the patient. For this reason, donors who have participated in high risk sexual behaviour say over one year ago, but do not do so currently, should be allowed to donate.

There is no strict definition of what high-risk behaviour/background is, but it would include those who have unprotected vaginal or anal sex with multiple partners (with a higher risk in men who have sex with men, or MSM), those who pay (or are paid) for sex, those from an geographical area with a very high prevalence of HIV and those with other sexually transmitted diseases.

Unprotected sex within a monogamous relationship is not necessarily seen as high-risk behaviour, regardless of whether it is a same-sex relationship.

==Guidance at RECRUITMENT==

UNACCEPTABLE

==Guidance at VT/WORK-UP==

TEMPORARY DEFERRAL

- Someone who has had sex for money or drugs --> defer for 3 months

- Sex with a high risk partner (ie with HIV, HBV, HCV, syphilis, HTLV, person who has received money or drugs for sex, person who has injected or been injected with non- medically prescribed drugs) -> defer for 3 months

- Sex with a partner who has been sexually active in areas where HIV is common --> defer for 3 months

- There is no deferral for men who had sex with men

* QUESTIONNAIRE:

1) Duration: Long-term partner/multiple partners

2) Protected sex?

3) Via: Vaginal / anal / oral

4) Partner/s: From high-prevalence HIV area? On IV drugs?

5) Paid for sex?

6) Time from the last sexual encounter

==Justification for guidance==

With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample oppotunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation with vastly outweigh the risk of transmission of an infectious agent.

For these reasons, the employment of fixed deferral periods for certain groups deemed to be at a higher risk of developing window period infection, particularly men who have had sex with men, is not recommended.

==Version==
Version 1, Edition 3

====Date of Last Update====
1 June 2016

High Risk Sexual Behaviour

2018-09-26T09:58:57Z

JoseRosSoto: /* Guidance at VT/WORK-UP */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor themselves currently participate in high-risk behaviour, or currently have sex with someone from a high-risk background. Importantly we rely on donors to assess their own individual risk.

The aim is to reduce the risk of 'window period' transmissions, where a donor is infected with (for example) HIV, but the infection is too recent to be picked up by our screening tests and the infection is passed to the patient. For this reason, donors who have participated in high risk sexual behaviour say over one year ago, but do not do so currently, should be allowed to donate.

There is no strict definition of what high-risk behaviour/background is, but it would include those who have unprotected vaginal or anal sex with multiple partners (with a higher risk in men who have sex with men, or MSM), those who pay (or are paid) for sex, those from an geographical area with a very high prevalence of HIV and those with other sexually transmitted diseases.

Unprotected sex within a monogamous relationship is not necessarily seen as high-risk behaviour, regardless of whether it is a same-sex relationship.

==Guidance at RECRUITMENT==

UNACCEPTABLE

==Guidance at VT/WORK-UP==

TEMPORARY DEFERRAL

- Someone who has had sex for money or drugs --> defer for 3 months

- Sex with a high risk partner (ie with HIV, HBV, HCV, syphilis, HTLV, person who has received money or drugs for sex, person who has injected or been injected with non- medically prescribed drugs) -> defer for 3 months

- Sex with a partner who has been sexually active in areas where HIV is common --> defer for 3 months

- There is no deferral for men who had sex with men

* Questionnaire:

1) Duration: Long-term partner/multiple partners

2) Protected sex?

3) Via: Vaginal / anal / oral

4) Partner/s: From high-prevalence HIV area? On IV drugs?

5) Paid for sex?

6) Time from the last sexual encounter

==Justification for guidance==

With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample oppotunity to identify those donors at increased risk of contracting a window-period infection.

In many cases, the benefit to the recipient of receiving a donation with vastly outweigh the risk of transmission of an infectious agent.

For these reasons, the employment of fixed deferral periods for certain groups deemed to be at a higher risk of developing window period infection, particularly men who have had sex with men, is not recommended.

==Version==
Version 1, Edition 3

====Date of Last Update====
1 June 2016

Syphilis

2018-09-26T09:53:56Z

JoseRosSoto: /* Guidance */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Sexually transmitted disease causing local genital disease as well as widespread organ disease, including heart and brain.

See also [http://en.wikipedia.org/wiki/Syphilis Syphilis]

==Guidance==
May be acceptable if fully treated and more than 12 months have passed since recovery + confirmatory microbiological tests must be performed to exclude recent infection.

After deferral period, a full sexual history should be taken to re-establish donor risk - see "High Risk Sexual Behaviour" for guidance

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Syphilis

2018-09-26T09:53:44Z

JoseRosSoto: /* Guidance */

Syphilis

2018-09-26T09:53:37Z

JoseRosSoto: /* Guidance */

Syphilis

2018-09-26T09:53:23Z

JoseRosSoto: /* Guidance */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Sexually transmitted disease causing local genital disease as well as widespread organ disease, including heart and brain.

See also [http://en.wikipedia.org/wiki/Syphilis Syphilis]

==Guidance==
May be acceptable if fully treated and more than 12 months have passed since recovery + confirmatory microbiological tests must be performed to exclude recent infection.

Discuss with a microbiologist if necessary.

After deferral period, a full sexual history should be taken to re-establish donor risk - see "High Risk Sexual Behaviour" for guidance

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Gonorrhoea

2018-09-26T09:52:46Z

JoseRosSoto: /* Guidance */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Bacterial infection commonly affecting the genital tract, caused by the organism Neisseria gonorrhoea.

==Guidance==
Acceptable if more than 12 months from completing treatment + confirmatory microbiological tests must be performed to exclude recent infection.

After deferral period, a full sexual history should be taken to re-establish donor risk - see "High Risk Sexual Behaviour" for guidance

==Pseudonyms or Related Conditions==
Clap

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Syphilis

2018-09-26T09:51:16Z

JoseRosSoto: /* Guidance */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Sexually transmitted disease causing local genital disease as well as widespread organ disease, including heart and brain.

See also [http://en.wikipedia.org/wiki/Syphilis Syphilis]

==Guidance==
May be acceptable if fully treated and more than 12 months have passed since recovery. Confirmatory microbiological tests must be performed to exclude recent infection.
Discuss with a microbiologist if necessary.

After deferral period, a full sexual history should be taken to re-establish donor risk - see "High Risk Sexual Behaviour" for guidance

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Thyroid Disease

2018-09-24T17:17:30Z

JoseRosSoto: /* Acceptable */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor / Recipient

==Explanation of Condition==
The thyroid gland produces thyroxine, which controls the body's rate of metabolism.

==Guidance==
====Unacceptable====
Malignant (cancerous);

Any thyroid disorder under investigation;

Graves disease (hyperthyroidism or thyrotoxicosis) within six months of treatment with radioactive iodine therapy;

Graves disease (hyperthyroidism or thyrotoxicosis) within 2 years of completing anti-thyroid tablet therapy (e.g. carbimazole);

Currently taking beta-blockers;

====Acceptable====
Hypothyroid (including Hashimoto thyroiditis) and stable for at least three months on thyroid replacement therapy;

Benign thyroid tumour (e.g. oncocytoma);

If in doubt, discuss with medical officer.

==Pseudonyms or Related Conditions==
Hypothyroidism

Hyperthyroidism

Hashimoto thyroiditis

Thyrotoxicosis

Graves disease/thyroiditis

Thyroid carcinoma

Oncocytoma of thyroid,

==Version==
Version 1, Edition 2

====Date of Last Update====
1 June 2016