Anthony Nolan Medical Guidelines - User contributions [en]

Malaria

2018-08-24T08:48:26Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved and a validated test for malaria antibody is negative, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return and a validated test for malaria antibody is negative, accept.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, and a validated test for malaria antibody is negative, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, and a validated test for malaria antibody is negative, accept.

'''d) For all other donors:'''
-If at least four months and less than 12 months have passed since return from a malaria endemic area, and a validated test for malaria antibody is negative, accept.
-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Malaria

2018-08-24T08:47:17Z

PaulM:

Malaria

2018-08-24T08:46:43Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved and a validated test for malaria antibody is negative, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return and a validated test for malaria antibody is negative, accept.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, and a validated test for malaria antibody is negative, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, and a validated test for malaria antibody is negative, accept.

'''d) For all other donors:'''
-If at least four months and less than 12 months have passed since return from a malaria endemic area, and a validated test for malaria antibody is negative, accept.
<nowiki></nowiki>-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Malaria

2018-08-24T08:45:55Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved and a validated test for malaria antibody is negative, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return and a validated test for malaria antibody is negative, accept.

'''b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:'''
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, and a validated test for malaria antibody is negative, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

'''c) Donors who have EVER been resident in a malaria endemic area for six months or more:'''
If at least four months have passed since the date of the last potential exposure to malaria, and a validated test for malaria antibody is negative, accept.

'''d) For all other donors:'''
-If at least four months and less than 12 months have passed since return from a malaria endemic area, and a validated test for malaria antibody is negative, accept.
<nowiki>Insert non-formatted text here</nowiki>-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Malaria

2018-08-24T08:44:16Z

PaulM:

Malaria

2018-08-24T08:43:36Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
'''a) Donors who have had malaria diagnosed in the past:'''
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved and a validated test for malaria antibody is negative, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return and a validated test for malaria antibody is negative, accept.

b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, and a validated test for malaria antibody is negative, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

c) Donors who have EVER been resident in a malaria endemic area for six months or more:
If at least four months have passed since the date of the last potential exposure to malaria, and a validated test for malaria antibody is negative, accept.

d) For all other donors:
-If at least four months and less than 12 months have passed since return from a malaria endemic area, and a validated test for malaria antibody is negative, accept.
-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Malaria

2018-08-24T08:43:04Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Parasitic infection transmitted by the bite of a female mosquito. Untreated, the condition may be rapidly fatal.

See also [http://en.wikipedia.org/wiki/Malaria Malaria]

==Guidance==
a) Donors who have had malaria diagnosed in the past:
If more than three years have passed since anti-malaria therapy has been completed and symptoms caused by malaria have resolved and a validated test for malaria antibody is negative, accept.
If the donor (with a history of malaria) has revisited a malaria endemic area and at least four months have passed since return and a validated test for malaria antibody is negative, accept.

b) Donors who have EVER had an undiagnosed fever that could have been malaria while in a malaria area or within four months of leaving a malaria endemic area:
If at least four months have passed since the donor returned from the malaria endemic area, or from the date of recovery from symptoms (undiagnosed fever) that may have been caused by malaria, whichever is later, and a validated test for malaria antibody is negative, accept.
NB. this may have to be increased to six months if the area is also identified as a risk area for T. cruzi or a tropical virus; the longest stipulated deferral period must be applied

c) Donors who have EVER been resident in a malaria endemic area for six months or more:
If at least four months have passed since the date of the last potential exposure to malaria, and a validated test for malaria antibody is negative, accept.

d) For all other donors:
-If at least four months and less than 12 months have passed since return from a malaria endemic area, and a validated test for malaria antibody is negative, accept.
-If travel to a malaria endemic area is more than 12 months prior to donation and the donor has never been diagnosed with malaria, has never had an undiagnosed fever while abroad or within four months of leaving a malaria endemic area and has not lived in a malaria endemic area for a continuous period of six months or more at any time of life, the donor can be accepted without the need for malaria antibody testing.
-If less than four months have passed, and if the donor has taken a full course of prophylaxis, the donor may proceed at the transplant centre's discretion. A malaria antibody test will be performed at medical. Inform Transplant Centre at VT

==Pseudonyms or Related Conditions==

==Version==
Version 2, Edition 1

====Date of Last Update====
1 June 2016

Typhoid

2018-08-24T07:25:57Z

PaulM:

==Acceptability at Recruitment==
Qualified

==Acceptability at CT / Work-Up==
Qualified

==Individual at Risk==
Recipient

==Explanation of Condition==
Bacterial Infection causing rash, fever and diarrhoea.

See also [http://en.wikipedia.org/wiki/Typhoid_fever]

==Guidance==
If more than seven days from completion of antibiotic course and last symptoms, accept.

Justification: Typhoid and paratyphoid are gastrointestinal infections which rarely have a chronic carrier state. It is usually caught while travelling. It is passed by the faecal-oral route and is not transfusion transmitted.
https://www.transfusionguidelines.org/dsg/bm/guidelines/in004-infection-chronic

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Immunisation

2018-08-22T10:04:12Z

PaulM: /* Bacterial */

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==

==Guidance==
Inform transplant centre if vaccinated within the three months prior to harvest. Establish type of vaccination given and whether live-attenuated, killed or subunit.

Live-attenuated vaccines may theoretically cause disease in the immunocompromised recipient.
===Examples of live vaccines===

====Viral====
Measles vaccine, mumps vaccine, rubella vaccine, chicken pox vaccine, oral polio vaccine (Sabin), yellow fever vaccine, and nasal-spray flu vaccine (including the seasonal flu nasal spray and the 2009 H1N1 flu nasal spray). Rabies vaccines are now available in two different attenuated forms, one for use in humans, and one for animal usage.

====Bacterial====
BCG vaccine, typhoid vaccine.

For further information, see JPAC guidelines: https://www.transfusionguidelines.org/dsg/bm/appendices/appendix-3-table-of-immunizations

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Immunisation

2018-08-22T10:04:00Z

PaulM:

Weight

2018-08-21T15:29:08Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==

AT RECRUITMENT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

AT VT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0 (If BMI 40-43 discuss with MO).

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0 (If BMI 35-40 discuss with MO).

Potential donors with BMI >35-40 may have complications prior, during and after the harvest:

- PBSC - poor venous access, need of central line insertion (and its subsequent complications). Risk is less clear than BM so greater discretion may be used.

- BM - should be carefully assessed for additional anaesthetic risk factors (e.g. cardiovascular, respiratory and endocrine disease). If no additional risk factors donor may at discretion of MO proceed to medical assessment when an anaesthetic opinion is mandatory before donor can be cleared to donate. At medical donor must also be examined to decide whether a BMH is technically possible. The collection centre must be alerted to this additional requirement before donor is sent to medical.

==Justification==
BMI is the most reliable tool to assess the body composition within the scientific community, and it is the criteria to based our decision upon.
It should be strictly followed at recruitment although donors outside these limits at work-up should be discus with the medical officer who may allow them to proceed after discussion with the Medical Director.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 3

====Date of Last Update====
3 November 2016

Innoculation Injury

2018-07-31T13:53:11Z

PaulM: /* Guidance */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Accidental penetration of the skin, or splash in the eye, with an object potentially contaminated with bodily fluids.

==Guidance==
Discuss each case with the medical officer.

Acceptable if three months have passed since injury. Unacceptable if needle/instrument may have been contaminated with abnormal prion protein.

This guidance applies as long as NAT testing for hepatitis C remains in place.

==Pseudonyms or Related Conditions==
Needlestick injury

Human bite

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Transfusion

2018-07-18T14:06:53Z

PaulM:

Juvenile Idiopathic Arthritis

2018-07-18T11:42:22Z

PaulM:

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
ACCEPTABLE

==Individual at Risk==
Donor / Recipient

==Explanation of Condition==
Form of inflammatory arthritis diagnosed during childhood that can resolve by puberty.

==Guidance==
If there are no current symptoms and donor has not received any treatment for >5 years --- > acceptable for PBSC/BM.

Otherwise not deemed to donate as risk of disease transmission to patient / disease flare-up in donor following G-CSF.

==Pseudonyms or Related Conditions==
Juvenile idiopathic arthritis

Juvenile rheumatoid arthritis

==Version==
Version 1, Edition 2

====Date of Last Update====
1 June 2016

Transfusion

2018-07-03T15:31:56Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==

Includes transfusion with :

red blood cells

platelets

fresh frozen plasma (FFP)

cryoprecipitate

buffy coat/white cell/neutrophils

intravenous or subcutaneous human normal immunoglobulin

==Guidance==

Establish:-

What blood component the donor received?

In which country the transfusion was given?

Which year the transfusion was given?

RECRUITMENT - Accept if transfused in UK, Europe, Australia, North America. If transfused outside these regions discuss case with MO

VT - Accept if transfused in UK, Europe, Australia, North America AND inform Transplant Centre. If transfused outside these regions discuss case with MO

UNACCEPTABLE:

1. At any time the donor has:

a) Received, or thinks they may have received, a transfusion of blood or
blood components in a country endemic for malaria or South American
trypanosomiasis. See ‘Discretionary’ section below for exceptions.

b) Has received regular treatment with blood-derived coagulation factor
concentrates.
This includes prothrombin complex to reverse over-anticoagulation.

2. Since January 1st 1980:

a) Anywhere in the world, the donor has received, or thinks they may have
received, a transfusion with red cells, platelets, fresh frozen plasma (FFP),
cryoprecipitate, intravenous or subcutaneous human normal
immunoglobulin. This includes mothers whose babies have required intrauterine
transfusion.

b) Had a plasma exchange performed.

3. Before January 1st 1999:

Treated with prothrombin complex to reverse over-anticoagulation

For the rest of the case, follow current JPAC guidelines in conjunction with transplant centre:

[http://www.transfusionguidelines.org/dsg/bm/guidelines/tr014-transfusion JPAC Transfusion Guidelines]

==Pseudonyms or Related Conditions==
Blood transfusion

==Version==
Version 1, Edition 2

====Date of Last Update====
3 November 2016

Fever

2018-06-18T11:11:25Z

PaulM: /* Guidance[edit] */

==Acceptability at Recruitment[edit]==

N/A

==Acceptability at CT / Work-Up[edit]==

See below

==Individual at Risk[edit]==
Donor and Recipient

==Explanation of Condition[edit]==
Abnormally high body temperature (>38.0 grades Celsius).

It can have many potential causes: different micro-organisms (bacterias, viruses, parasites), medication (G-CSF included), etc

==Guidance[edit]==

Unacceptable if accompanied by shivering, cough or there is an evident source of infection:

- Shortness of breath, productive/dry cough and or chest pain - respiratory source

- Abdominal pain, diarrhoea and/or vomiting - gastrointestinal source

- Severe headache accompanied with loss of consciousness, delirium and neck pain - meningitis or other brain infections

If isolated fever with no clear source of infection and donor is currently on G-CSF, it can potentially cause self-limited fever and flu-like symptoms, therefore donation may not need to be deferred (as per discretion of attending Medical Officer/Medical Director).

==Pseudonyms or Related Conditions[edit]==

==Version[edit]==
Version 1, Edition 1

==Date of Last Update[edit]==
18th June 2018

Fever

2018-06-18T11:11:12Z

PaulM:

Fever

2018-06-18T11:10:45Z

PaulM:

==Acceptability at Recruitment[edit]==

N/A

==Acceptability at CT / Work-Up[edit]==

See below

Individual at Risk[edit]
Donor and Recipient

Explanation of Condition[edit]
Abnormally high body temperature (>38.0 grades Celsius).

It can have many potential causes: different micro-organisms (bacterias, viruses, parasites), medication (G-CSF included), etc

Guidance[edit]

Unacceptable if accompanied by shivering, cough or there is an evident source of infection:

- Shortness of breath, productive/dry cough and or chest pain - respiratory source

- Abdominal pain, diarrhoea and/or vomiting - gastrointestinal source

- Severe headache accompanied with loss of consciousness, delirium and neck pain - meningitis or other brain infections

If isolated fever with no clear source of infection and donor is currently on G-CSF, it can potentially cause self-limited fever and flu-like symptoms, therefore donation may not need to be deferred (as per discretion of attending Medical Officer/Medical Director).

Pseudonyms or Related Conditions[edit]

Version[edit]
Version 1, Edition 1

Date of Last Update[edit]
18th June 2018

Fever

2018-06-18T11:10:08Z

PaulM: Created page with "Acceptability at Recruitment[edit] N/A Acceptability at CT / Work-Up[edit] See below Individual at Risk[edit] Donor and Recipient Explanation of Condition[edit] Abnormally..."

Acceptability at Recruitment[edit]
N/A

Acceptability at CT / Work-Up[edit]
See below

Individual at Risk[edit]
Donor and Recipient

Explanation of Condition[edit]
Abnormally high body temperature (>38.0 grades Celsius).

It can have many potential causes: different micro-organisms (bacterias, viruses, parasites), medication (G-CSF included), etc

Guidance[edit]

Unacceptable if accompanied by shivering, cough or there is an evident source of infection:

- Shortness of breath, productive/dry cough and or chest pain - respiratory source

- Abdominal pain, diarrhoea and/or vomiting - gastrointestinal source

- Severe headache accompanied with loss of consciousness, delirium and neck pain - meningitis or other brain infections

If isolated fever with no clear source of infection and donor is currently on G-CSF, it can potentially cause self-limited fever and flu-like symptoms, therefore donation may not need to be deferred (as per discretion of attending Medical Officer/Medical Director).

Pseudonyms or Related Conditions[edit]

Version[edit]
Version 1, Edition 1

Date of Last Update[edit]
18th June 2018

Central Nervous System Disease

2018-06-18T10:54:12Z

PaulM: /* Date of Last Update */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor / Recipient

==Explanation of Condition==
Any disorder affecting the brain or spinal cord.

==Guidance==

CNS disease of unknown origin, and clinically isolated syndrome, are reasons for obligatory deferral and to permit individual risk assessment where appropriate.

===Not acceptable if===

Suffering from dementia or Parkinson disease;

History of CNS disease of unknown or suspected infective aetiology such as Creutzfeld Jacob disease (CJD), optic neuritis, clinically isolated syndrome,
transverse myelitis or multiple sclerosis.

Neurodegenerative disease of unknown aetiology.

Stroke, TIA (transient ischaemic attack) or cerebral embolus.

Disability physically prohibits either PBSC or bone marrow donation.

Discuss with medical officer if unclear history or aetiology.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
28th June 2018

Central Nervous System Disease

2018-06-18T10:53:56Z

PaulM: /* Guidance */

Central Nervous System Disease

2018-06-18T10:52:59Z

PaulM: /* Not acceptable if */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor / Recipient

==Explanation of Condition==
Any disorder affecting the brain or spinal cord.

==Guidance==

Discuss with medical officer.

===Not acceptable if===

Suffering from dementia or Parkinson disease;

History of CNS disease of unknown or suspected infective aetiology such as Creutzfeld Jacob disease (CJD), optic neuritis, clinically isolated syndrome,
transverse myelitis or multiple sclerosis.

Neurodegenerative disease of unknown aetiology.

Stroke, TIA (transient ischaemic attack) or cerebral embolus.

Disability physically prohibits either PBSC or bone marrow donation.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

G6PD Deficiency

2018-06-18T10:49:15Z

PaulM: /* Guidance */

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
Deficiency of an enzyme important in providing energy to cells, particularly red blood cells. Sufferers are prone to breakdown of red blood cells (haemolysis) when exposed to certain drugs or other physiological stresses. This is an X linked red cell enzyme deficiency that is variable in its severity. Suitability as a donor should be discussed with the attending Medical Officer. The condition would be transmissible to recipient of
stem cells so Transplant Centres need to undertake their own risk assessment.

==Guidance==
Discuss with Medical Officer.

Unacceptable if severe.

If mild, may donate. In this case, inform transplant centre. If candidate for BM, discuss with anaesthetist.

==Pseudonyms or Related Conditions==
Glucose-6-Phosphate Deficiency

==Version==
Version 1, Edition 1

====Date of Last Update====
1 June 2016

G6PD Deficiency

2018-06-18T10:46:49Z

PaulM: /* Explanation of Condition */

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
Deficiency of an enzyme important in providing energy to cells, particularly red blood cells. Sufferers are prone to breakdown of red blood cells (haemolysis) when exposed to certain drugs or other physiological stresses. This is an X linked red cell enzyme deficiency that is variable in its severity. Suitability as a donor should be discussed with the attending Medical Officer. The condition would be transmissible to recipient of
stem cells so Transplant Centres need to undertake their own risk assessment.

==Guidance==
Discuss with Medical Officer. Unacceptable if severe. If mild may donate but discuss with anaesthetist and inform transplant centre.

==Pseudonyms or Related Conditions==
Glucose-6-Phosphate Deficiency

==Version==
Version 1, Edition 1

====Date of Last Update====
1 June 2016

Gaucher Disease

2018-06-18T10:43:38Z

PaulM: /* Pseudonyms or Related Conditions */

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
NOT ACCEPTABLE

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited disease causing accumulation of fatty substances in all organs of the body, including the bone marrow.

==Guidance==
Inherited metabolic disease involving the bone marrow. Unacceptable.

==Pseudonyms or Related Conditions==

Glycogen Storage Disease

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Haemoglobin Disorder

2018-06-18T10:09:27Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Covers a wide variety of inhertied disorders of haemoglobin, of which the most common will be thalassaemia and sickle cell disease.

==Guidance==
Discuss with MO and inform transplant centre.

===Unacceptable===
Thalassaemia major or intermedia

Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD)

High affinity haemoglobin

Other clinically significant structural or functional haemoglobinopathies.

If mother or father homozygous or heterozygous for inherited haemoglobin
disorders and infant affected

===Acceptable if haemoglobin is within normal sex-adjusted range===
Alpha or beta thalassaemia trait

Sickle cell trait

HbC, HbDPunjab/Oman, HbE traits

Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait.

There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 2

====Date of Last Update====
1 June 2016

Hepatitis A

2018-06-18T10:05:07Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Viral liver infection transmitted, usually, through contaminated food or water supplies, and sexual activity. It is particularly common in less developed countries, but also found throughout the developed world. The illness is self limiting and there is no risk of long-term infection or carriage of the virus, but it can be fatal.

==Guidance==

Acceptable if:

a) More than 6 months from recovery

b) More than 6 months from recovery of partner , or from last sexual contact if a former sexual partner

c) Fully recovered, documented HAV RNA negative, anti HAV IgG positive after recovery.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Hepatitis E

2018-06-18T09:59:48Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Viral liver infection similar in transmission and illness to hepatitis A.

==Guidance==
Acceptable if

a) More than 6 months from recovery.
b) If less than 6 months from recovery but HEV RNA negative and anti-HEV IgG positive,

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Pregnancy

2018-06-18T09:55:04Z

PaulM: /* Unacceptable */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Guidance==
====Unacceptable====

a) Currently pregnant

b) Less than one week has passed for every completed week of a recent pregnancy up to 6 months. After 6 months post-partum women may donate but check whether still [[breastfeeding]]

c) Less than three months have passed since a first trimester [[Miscarriage]]

d) The pregnancy resulted in a malignant [http://en.wikipedia.org/wiki/Hydatiform_mole hydatidiform mole]

e) The pregnancy resulted in a non-malignant hydatidiform mole and treatment and follow-up is ongoing

f) If less than 7 days from the last dose of methotrexate.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 2

====Date of Last Update====
June 2016

Pregnancy

2018-06-18T09:54:33Z

PaulM: /* Unacceptable */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Guidance==
====Unacceptable====

Currently pregnant

Less than one week has passed for every completed week of a recent pregnancy up to 6 months. After 6 months post-partum women may donate but check whether still [[breastfeeding]]

Less than three months have passed since a first trimester [[Miscarriage]]

The pregnancy resulted in a malignant [http://en.wikipedia.org/wiki/Hydatiform_mole hydatidiform mole]

The pregnancy resulted in a non-malignant hydatidiform mole and treatment and follow-up is ongoing

If less than 7 days from the last dose of methotrexate.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 2

====Date of Last Update====
June 2016

Organ or tissue transplant

2018-06-18T09:45:53Z

PaulM:

==Acceptability at Recruitment==
See below

==Acceptability at CT / Work-Up==
See below

==Individual at Risk==
Recipient

==Explanation of Condition==

The transfer of tissues or organs between individuals and species has
lead to the spread of infection.

==Guidance==

UNACCEPTABLE IF:

1. At any time:

a) Has needed immunosuppression.

b) Dura mater transplanted.

c) Ocular tissue transplanted.

d) Xenotransplant performed.

2. Since January 1st 1980:

Any allogeneic human tissue or organ transplanted.

ACCEPTABLE IF:

a) If an allogeneic tissue or cell transplant was performed before
January 1st 1980 and there is no other reason to exclude the donor.

b) If at anytime an autologous tissue, or cells, has been transplanted.

c) For donations of heart valves, skin, ocular tissue and pancreatic islets: If
at anytime a allogeneic tissue, or cells, has been transplanted

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
18th June 2018

Organ or tissue transplant

2018-06-18T09:45:09Z

PaulM:

==Acceptability at Recruitment==
See below

==Acceptability at CT / Work-Up==
See below

==Individual at Risk==
Recipient

==Explanation of Condition==

==Guidance==

UNACCEPTABLE IF:

1. At any time:

a) Has needed immunosuppression.

b) Dura mater transplanted.

c) Ocular tissue transplanted.

d) Xenotransplant performed.

2. Since January 1st 1980:

Any allogeneic human tissue or organ transplanted.

ACCEPTABLE IF:

a) If an allogeneic tissue or cell transplant was performed before
January 1st 1980 and there is no other reason to exclude the donor.

b) If at anytime an autologous tissue, or cells, has been transplanted.

c) For donations of heart valves, skin, ocular tissue and pancreatic islets: If
at anytime a allogeneic tissue, or cells, has been transplanted

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
18th June 2018

Organ or tissue transplant

2018-06-18T09:44:39Z

PaulM: Created page with "==Acceptability at Recruitment== See below ==Acceptability at CT / Work-Up== See below ==Individual at Risk== Recipient ==Explanation of Condition== ==Guidance== UNACCEP..."

Transfusion

2018-06-18T09:39:28Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==

Includes transfusion with :

red blood cells

platelets

fresh frozen plasma (FFP)

cryoprecipitate

buffy coat/white cell/neutrophils

intravenous or subcutaneous human normal immunoglobulin

==Guidance==

Establish:-

What blood component the donor received?

In which country the transfusion was given?

Which year the transfusion was given?

RECRUITMENT - Accept if transfused in UK, Europe, Australia, North America. If transfused outside these regions discuss case with MO

VT - Accept if transfused in UK, Europe, Australia, North America AND inform Transplant Centre. If transfused outside these regions discuss case with MO

UNACCEPTABLE:

1. At any time the donor has:

a) Received, or thinks they may have received, a transfusion of blood or
blood components in a country endemic for malaria or South American
trypanosomiasis. See ‘Discretionary’ section below for exceptions.

b) Has received regular treatment with blood derived coagulation factor
concentrates.
Treated with blood derived coagulation factor concentrates. This includes
prothrombin complex to reverse over-anticoagulation.

2. Since January 1st 1980:

a) Anywhere in the world, the donor has received, or thinks they may have
received, a transfusion with red cells, platelets, fresh frozen plasma (FFP),
cryoprecipitate, intravenous or subcutaneous human normal
immunoglobulin. This includes mothers whose babies have required intrauterine
transfusion.

b) Had a plasma exchange performed.

3. Before January 1st 1999:

Treated with prothrombin complex to reverse over-anticoagulation

For the rest of the case, follow current JPAC guidelines in conjunction with transplant centre:

[http://www.transfusionguidelines.org/dsg/bm/guidelines/tr014-transfusion JPAC Transfusion Guidelines]

==Pseudonyms or Related Conditions==
Blood transfusion

==Version==
Version 1, Edition 2

====Date of Last Update====
3 November 2016

Transfusion

2018-06-18T09:39:05Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==

Includes transfusion with :

red blood cells

platelets

fresh frozen plasma (FFP)

cryoprecipitate

buffy coat/white cell/neutrophils

intravenous or subcutaneous human normal immunoglobulin

==Guidance==

Establish:-

What blood component the donor received?

In which country the transfusion was given?

Which year the transfusion was given?

RECRUITMENT - Accept if transfused in UK, Europe, Australia, North America. If transfused outside these regions discuss case with MO

VT - Accept if transfused in UK, Europe, Australia, North America AND inform Transplant Centre. If transfused outside these regions discuss case with MO

UNACCEPTABLE:

1. At any time the donor has:

a) Received, or thinks they may have received, a transfusion of blood or
blood components in a country endemic for malaria or South American
trypanosomiasis. See ‘Discretionary’ section below for exceptions.

b) Has received regular treatment with blood derived coagulation factor
concentrates.
Treated with blood derived coagulation factor concentrates. This includes
prothrombin complex to reverse over-anticoagulation.

2. Since January 1st 1980:

a) Anywhere in the world, the donor has received, or thinks they may have
received, a transfusion with red cells, platelets, fresh frozen plasma (FFP),
cryoprecipitate, intravenous or subcutaneous human normal
immunoglobulin. This includes mothers whose babies have required intrauterine
transfusion.

b) Had a plasma exchange performed.

3. Before January 1st 1999:

Treated with prothrombin complex to reverse over-anticoagulation

For the rest of the case, follow current JPAC guidelines in conjunction with transplant centre:

[http://www.transfusionguidelines.org/dsg/bm/guidelines/tr014-transfusion JPAC Transfusion Guidelines]

==Pseudonyms or Related Conditions==
Blood transfusion

==Version==
Version 1, Edition 2

====Date of Last Update====
3 November 2016

Transfusion

2018-06-18T09:38:38Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==

Includes transfusion with :

red blood cells

platelets

fresh frozen plasma (FFP)

cryoprecipitate

buffy coat/white cell/neutrophils

intravenous or subcutaneous human normal immunoglobulin

==Guidance==

Establish:-

What blood component the donor received?

In which country the transfusion was given?

Which year the transfusion was given?

RECRUITMENT - Accept if transfused in UK, Europe, Australia, North America. If transfused outside these regions discuss case with MO

VT - Accept if transfused in UK, Europe, Australia, North America AND inform Transplant Centre. If transfused outside these regions discuss case with MO

UNACCEPTABLE:

1. At any time the donor has:

a) Received, or thinks they may have received, a transfusion of blood or
blood components in a country endemic for malaria or South American
trypanosomiasis. See ‘Discretionary’ section below for exceptions.

b) Has received regular treatment with blood derived coagulation factor
concentrates.
Treated with blood derived coagulation factor concentrates. This includes
prothrombin complex to reverse over-anticoagulation.

2. Since January 1st 1980:

a) Anywhere in the world, the donor has received, or thinks they may have
received, a transfusion with red cells, platelets, fresh frozen plasma (FFP),
cryoprecipitate, intravenous or subcutaneous human normal
immunoglobulin. This includes mothers whose babies have required intrauterine
transfusion.

b) Had a plasma exchange performed.

3. Before January 1st 1999:

Treated with prothrombin complex to reverse over-anticoagulation

For the rest of the case, follow current JPAC guidelines in conjunction with transplant centre:

[http://www.transfusionguidelines.org/dsg/bm/guidelines/tr014-transfusion JPAC Transfusion Guidelines]

==Pseudonyms or Related Conditions==
Blood transfusion

==Version==
Version 1, Edition 2

====Date of Last Update====
3 November 2016

Viral Haemorrhagic Fever

2018-06-18T09:30:13Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Viral haemorrhagic fever.

==Guidance==

For up-to-date guidance also see [[http://www.transfusionguidelines.org/dsg/bm]]

Unacceptable:

a) Was present in an area during an active outbreak

b) Under investigation for viral haemorrhagic fever

c) Has been in contact with an individual who was present in an area
during an active outbreak

d) Was in contact with an individual infected with, or was under
investigation for viral haemorrhagic fever

e) less than six months after return to UK from an endemic area when
there was no active outbreak.

Acceptable:

a. If more than 6 months after return to UK from an endemic area when
there was no active outbreak at the time of visit

b. If the individual, or the contact person, under investigation had viral
haemorrhagic fever infection excluded as diagnosis.

==Examples of viral haemorrhagic fever==
Ebola

Marburg

Lassa

Crimean-Congo Haemorrhagic Fever

==version==

Version 1.0.

1 June 2016

Viral Haemorrhagic Fever

2018-06-18T09:29:52Z

PaulM:

Viral Haemorrhagic Fever

2018-06-18T09:29:19Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Viral haemorrhagic fever.

==Guidance==

For up-to-date guidance also see [[http://www.transfusionguidelines.org/dsg/bm]]

Unacceptable:
a) Was present in an area during an active outbreak
b) Under investigation for viral haemorrhagic fever
c) Has been in contact with an individual who was present in an area
during an active outbreak
d) Was in contact with an individual infected with, or was under
investigation for viral haemorrhagic fever
e) less than six months after return to UK from an endemic area when
there was no active outbreak.

Acceptable:
a. If more than 6 months after return to UK from an endemic area when
there was no active outbreak at the time of visit
b. If the individual, or the contact person, under investigation had viral
haemorrhagic fever infection excluded as diagnosis.
==Examples of viral haemorrhagic fever==
Ebola

Marburg

Lassa

Crimean-Congo Haemorrhagic Fever

==version==

Version 1.0.

1 June 2016

Epidermolysis Bullosa

2018-05-22T08:16:07Z

PaulM:

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
ACCEPTABLE

==Individual at Risk==
Donor

==Explanation of Condition==
Inherited disorder where skin becomes very fragile after minor trauma or friction due to a defect in attachment within the skin layers.
It produces hemorrhagic blisters and subsequent broken skin, that can lead to anaemia.

==Guidance==
Unacceptable if patients develop blisters easily, mainly in the upper arms and trunk (injection site for G-CSF) and/or lower back (for BM harvest). Also if develops anaemia and haemoglobin drops below the acceptable cut-off value.

If small blisters located in areas such as lower limbs and normal haemoglobin, proceed.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Epidermolysis Bullosa

2018-05-22T08:14:30Z

PaulM:

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
ACCEPTABLE

==Individual at Risk==
Donor

==Explanation of Condition==
Inherited disorder where skin becomes very fragile after minor trauma or friction due to a defect in attachment within the skin layers.
It produces hemorrhagic blisters and subsequent broken skin.

==Guidance==
Unacceptable if patients develop blisters easily, mainly in the upper arms and trunk (injection site for G-CSF) and/or lower back (for BM harvest).

If small blisters located in areas such as lower limbs, proceed.

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Epidermolysis Bullosa

2018-05-22T08:13:30Z

PaulM:

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
ACCEPTABLE

==Individual at Risk==
Donor

==Explanation of Condition==
Inherited disorder where skin becomes very fragile after minor trauma or friction due to a defect in attachment within the skin layers.
It produces hemorrhagic blisters and subsequent broken skin.

==Guidance==
Unacceptable if patients develop blisters easily, mainly in the upper arms and trunk (injection site for G-CSF) and/or lower back (for BM harvest).

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

Weight

2018-05-05T10:16:56Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==

AT RECRUITMENT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

AT VT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0 (If BMI 40-43 discuss with MO).

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0 (If BMI 35-40 discuss with MO).

Potential donors with BMI >35-40 may have complications prior, during and after the harvest:

- PBSC - poor venous access, need of central line insertion (and it subsequent complications). Risk is less clear than BM so greater discretion may be used.

- BM - should be carefully assessed for additional anaesthetic risk factors (e.g. cardiovascular, respiratory and endocrine disease). If no additional risk factors donor may at discretion of MO proceed to medical assessment when an anaesthetic opinion is mandatory before donor can be cleared to donate. At medical donor must also be examined to decide whether a BMH is technically possible. The collection centre must be alerted to this additional requirement before donor is sent to medical.

==Justification==
BMI is the most reliable tool to assess the body composition within the scientific community, and it is the criteria to based our decision upon.
It should be strictly followed at recruitment although donors outside these limits at work-up should be discus with the medical officer who may allow them to proceed after discussion with the Medical Director.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 3

====Date of Last Update====
3 November 2016

Weight

2018-05-05T10:16:37Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==

AT RECRUITMENT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

AT VT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0 (If BMI 40-43 discuss with MO).

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0 (If BMI 35-40 discuss with MO).

Potential donors with BMI >35-40 may have complications prior, during and after the harvest:

- PBSC - poor venous access, need of central line insertion (and it subsequent complications). Risk is less clear than BM so greater discretion may be used.

- BM - should be carefully assessed for additional anaesthetic risk factors (e.g. cardiovascular, respiratory and endocrine disease). If no additional risk factors donor may at discretion of MO proceed to medical assessment when an anaesthetic opinion is mandatory before donor can be cleared to donate. At medical donor must also be examined to decide whether a BMH is technically possible. The collection centre must be alerted to this additional requirement before donor is sent to medical.

==Justification==
BMI is the most reliable tool to assess the body composition within the scientific community, and it is the criteria to based our decision upon.
It should be strictly followed at recruitment although donors outside these limits at work-up should be discus with the medical officer who may allow them to proceed after discussion with the Medical Director.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 3

====Date of Last Update====
3 November 2016

Weight

2018-05-05T10:15:55Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==

AT RECRUITMENT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

AT VT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0 (If BMI 40-43 discuss with MO).

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0 (If BMI 35-40 discuss with MO).

Potential donors with BMI >35-40 may have complications prior, during and after the harvest:

- PBSC - poor venous access, need of central line insertion (and it subsequent complications). Risk is less clear than BM so greater discretion may be used.

- BM - should be carefully assessed for additional anaesthetic risk factors (e.g. cardiovascular, respiratory and endocrine disease). If no additional risk factors donor may at discretion of MO proceed to medical assessment when an anaesthetic opinion is mandatory before donor can be cleared to donate. At medical donor must also be examined to decide whether a BMH is technically possible. The collection centre must be alerted to this additional requirement before donor is sent to medical.

BMI is the most reliable tool to assess the body composition within the scientific community, and it is the criteria to based our decision upon.
It should be strictly followed at recruitment although donors outside these limits at work-up should be discus with the medical officer who may allow them to proceed after discussion with the Medical Director.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 3

====Date of Last Update====
3 November 2016

Weight

2018-05-05T10:15:40Z

PaulM: /* Guidance */

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==

AT RECRUITMENT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

AT VT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0 (If BMI 40-43 discuss with MO).

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0 (If BMI 35-40 discuss with MO).

Potential donors with BMI >35-40 may have complications prior, during and after the harvest:

- PBSC - poor venous access, need of central line insertion (and it subsequent complications). Risk is less clear than BM so greater discretion may be used.

- BM - should be carefully assessed for additional anaesthetic risk factors (e.g. cardiovascular, respiratory and endocrine disease). If no additional risk factors donor may at discretion of MO proceed to medical assessment when an anaesthetic opinion is mandatory before donor can be cleared to donate. At medical donor must also be examined to decide whether a BMH is technically possible. The collection centre must be alerted to this additional requirement before donor is sent to medical.

BMI is the most reliable tool to assess the body composition within the scientific community, and it is the criteria to based our decision upon.
It should be strictly followed at recruitment although donors outside these limits at work-up should be discus with the medical officer who may allow them to proceed after discussion with the Medical Director.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 3

====Date of Last Update====
3 November 2016

Weight

2018-05-05T10:15:23Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==

To calculate BMI, use this calculator:

[http://www.nhs.uk/Tools/Pages/Healthyweightcalculator.aspx NHS BMI Calculator]

==Guidance==

AT RECRUITMENT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0.

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0.

AT VT

Acceptable

- For PBSC - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 40.0 (If BMI 40-43 discuss with MO).

- For BM - if over 50kg (or 7st 12lb) and BMI less than, or equal to, 35.0 (If BMI 35-40 discuss with MO).

Potential donors with BMI >35-40 may have complications prior, during and after the harvest:

- PBSC - poor venous access, need of central line insertion (and it subsequent complications). Risk is less clear than BM so greater discretion may be used.

- BM - should be carefully assessed for additional anaesthetic risk factors (e.g. cardiovascular, respiratory and endocrine disease). If no additional risk factors donor may at discretion of MO proceed to medical assessment when an anaesthetic opinion is mandatory before donor can be cleared to donate. At medical donor must also be examined to decide whether a BMH is technically possible. The collection centre must be alerted to this additional requirement before donor is sent to medical.

BMI is the most reliable tool to assess the body composition within the scientific community, and it is the criteria to based our decision upon.
It should be strictly followed at recruitment although donors outside these limits at work-up should be discus with the medical officer who may allow them to proceed after discussion with the Medical Director.

==Pseudonyms or Related Conditions==
Obesity

==Version==
Version 1, Edition 3

====Date of Last Update====
3 November 2016

Breastfeeding

2018-04-25T15:17:38Z

PaulM:

==Acceptability at Recruitment==
ACCEPTABLE, but should be deferred for 6 months after labour.

==Acceptability at CT / Work-Up==
QUALIFIED, see below

==Individual at Risk==
Donor

==Guidance==

For Bone Marrow - donors willing to donate BM and who wish to resume breastfeeding post donation, should wait for at least 24 hours after the last dose of anaesthetic was administered, to avoid transfer it to the baby (general anaesthesia may cause severe events in the baby).

For PBSC - donors willing to donate PBSC should stop breastfeeding prior to the first dose of G-CSF and resume it at least 48 hours after the last dose has been administered, also to avoid contact of the baby with G-CSF. The safety profile of G-CSF has not been tested during pregnancy thus the it is unknown whether baby is at risk of adverse events.

==Pseudonyms or Related Conditions==

Breastfeeding

2018-04-25T15:17:16Z

PaulM: Created page with "==Acceptability at Recruitment== ACCEPTABLE, but should be deferred for 6 months after labour. ==Acceptability at CT / Work-Up== QUALIFIED, see below ==Individual at Risk==..."

Pregnancy

2018-04-25T15:00:45Z

PaulM:

==Acceptability at Recruitment==
QUALIFIED

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Guidance==
====Unacceptable====
Currently pregnant;

Less than one week has passed for every completed week of a recent pregnancy up to 6 months. After 6 months post-partum women may donate but check whether still [[breastfeeding]]

Less than three months have passed since a first trimester [[Miscarriage]]

The pregnancy resulted in a malignant [http://en.wikipedia.org/wiki/Hydatiform_mole hydatidiform mole]

The pregnancy resulted in a non-malignant hydatidiform mole and treatment and follow-up is ongoing

==Pseudonyms or Related Conditions==

==Version==
Version 1, Edition 2

====Date of Last Update====
June 2016