Anthony Nolan Medical Guidelines - Recent changes [en]

Reactive Hypoglycaemia

Ellouise.Bishop@anthonynolan.org — Tue, 28 Apr 2026 14:39:24 GMT

Created page with "==Acceptability at Recruitment== ACCEPTABLE ==Acceptability at VT / Work-Up== QUALIFIED ==Individual at Risk== Donor ==Explanation of Condition== Reactive hypoglycaemia is..."

New page

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at VT / Work-Up==
QUALIFIED

==Individual at Risk==
Donor

==Explanation of Condition==
Reactive hypoglycaemia is a condition that results in episodes of low blood glucose (blood sugar) levels after eating. These episodes usually occur two to four hours after a meal. It is thought that reactive hypoglycaemia is caused by the over-production of the hormone insulin (which lowers blood glucose levels) following a meal that is high in carbohydrates. Reactive hypoglycaemia is closely linked to what you eat and can often be managed by changes to your diet.

==Guidance==
Discuss with MO

Case by case assessment:
Assess symptom burden and frequency.
Enquire if this condition has been investigated (any formal blood glucose tests, hormone levels, scans etc) and does the donor have results of these tests?

If largely asymptomatic and well controlled can go ahead. If poorly controlled or symptomatic more than weekly, unacceptable -> defer.

==Pseudonyms or Related Conditions==
Low blood sugar / glucose

==Version==
Version 1, Edition 1

====Date of Last Update====
28 April 2026

Main Page

Ellouise.Bishop@anthonynolan.org — Tue, 28 Apr 2026 14:31:53 GMT

Epilepsy

Ellouise.Bishop@anthonynolan.org — Tue, 28 Apr 2026 14:28:12 GMT

Guidance

South American Trypanosomiasis

Ellouise.Bishop@anthonynolan.org — Tue, 28 Apr 2026 14:16:01 GMT

Justification for guidance

Main Page

Ellouise.Bishop@anthonynolan.org — Tue, 28 Apr 2026 14:03:32 GMT

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	[[Reactive Arthritis]]		[[Reactive Arthritis]]
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		+	[[Reactive Hypoglycaemia]]

	[[Reflex Sympathetic Dystrophy]]		[[Reflex Sympathetic Dystrophy]]

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 Chagas’ is endemic to mainland South and Central America. The people most at risk are those who spend early childhood in an endemic area in certain types of dwelling, those who receive blood transfusions in endemic areas, and children whose mothers grew up at risk of Chagas’ disease. Most of this risk can be captured by asking donors their country of birth and whether they have ever received a blood transfusion in a Chagas’-endemic country. The former can be definitively captured at recruitment, while the latter could occur at any time up to work-up.
-Although the risk of Trypanosoma cruzi infection to travellers is considered very low, a possible case (likely false positive) in 2024 involving a donor who had recently returned from a short holiday to South America prompted a revision of guidelines. These updated guidelines recommend screening travellers who may have been exposed to the parasite, namely those who have stayed in rural areas AND in high-risk housing conditions (mud-lined huts, adobe housing, structures with thatched rooves).
+Risk of Trypanosoma cruzi infection to travellers is considered very low. In keeping with JPAC guidelines it is only recommended screening travellers who may have been exposed to the parasite with certain activity in at risk countries: namely those who have lived and/or worked in rural subsistence farming communities for a continuous period of four weeks or more. Camping or trekking in the jungle in South or Central America (including Mexico) is not considered of high enough risk to merit exclusion.
 The detection of antibodies to T. cruzi is an established strategy to prevent transmission of infection through blood transfusion. Where available, this strategy can be adapted to assess the risk of prospective HPC donors with identified risk factors for chronic, asymptomatic Chagas’ disease. Because the prevalence of Chagas’ disease varies widely within the populations of endemic areas, it is likely that most donors with identified risk factors – especially those residing in non-endemic countries – will test negative for T. cruzi antibodies.

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 ==Guidance==
 Unacceptable if has had an epileptic event in the last year or if there is an underlying organic pathology. Otherwise acceptable.
 ==Pseudonyms or Related Conditions==

← Older revision		Revision as of 14:03, 28 April 2026
(One intermediate revision by the same user not shown)