Anthony Nolan Medical Guidelines - Recent changes [en]

Polyendocrine metabolic ovarian syndrome

Natalie.Murray@anthonynolan.org — Thu, 11 Jun 2026 15:27:32 GMT

Main Page

Natalie.Murray@anthonynolan.org — Thu, 11 Jun 2026 15:18:45 GMT

Polyendocrine metabolic ovarian syndrome

Natalie.Murray@anthonynolan.org — Thu, 11 Jun 2026 15:18:22 GMT

Created page with "==Acceptability at Recruitment== ACCEPTABLE ==Acceptability at VT / Work-Up== ACCEPTABLE ==Individual at Risk== ==Explanation of Condition== Disorder of female sex hormone..."

New page

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at VT / Work-Up==
ACCEPTABLE

==Individual at Risk==

==Explanation of Condition==
Disorder of female sex hormone regulation leading to multiple cysts forming within the ovaries, as well as development of some male sexual characteristics, such as facial hair. May be treated with metformin.

See also [https://en.wikipedia.org/wiki/Polyendocrine_metabolic_ovarian_syndrome]

==Guidance==
Acceptable, even if taking metformin.

Enquire about other drugs and discuss with medical officer if unsure.

==Pseudonyms or Related Conditions==
Polycystic Ovary Syndrome

PCOS

==Version==
Version 1, Edition 1

====Date of Last Update====
11th June 2026

Polycystic Ovarian Syndrome

Natalie.Murray@anthonynolan.org — Thu, 11 Jun 2026 15:17:11 GMT

Main Page

Natalie.Murray@anthonynolan.org — Wed, 10 Jun 2026 10:59:54 GMT

Limb Difference

Natalie.Murray@anthonynolan.org — Wed, 10 Jun 2026 10:51:25 GMT

Acceptability at VT / Work-Up

Limb Difference

Natalie.Murray@anthonynolan.org — Wed, 10 Jun 2026 10:46:57 GMT

Created page with "==Acceptability at Recruitment== ACCEPTED - donor must be informed that they may require a central line at donation. https://www.anthonynolan.org/donation-journey/peripheral-..."

New page

==Acceptability at Recruitment==
ACCEPTED - donor must be informed that they may require a central line at donation.

https://www.anthonynolan.org/donation-journey/peripheral-blood-stem-cell-pbsc-donation/having-a-central-line

==Acceptability at VT / Work-Up==
At VT Consider cause and discuss with medical team.
At work up - on a case by case basis in discussion with collection centre.

Donor should be made aware that they may not be able to proceed depending on review at medical appointment.

==Individual at Risk==
Donor

==Explanation of Condition==
A limb difference is a term used to describe an arm or leg that is shaped differently or functions in a unique way compared to the typical human anatomy. This includes limbs that are missing, underdeveloped, malformed, or have a significant size difference.

==Pseudonyms or Related Conditions==
Erb's Palsy

==Version==
Version 1, Edition 1

====Date of Last Update====
10th June 2026

Main Page

Natalie.Murray@anthonynolan.org — Wed, 10 Jun 2026 10:35:39 GMT

Main Page

Tania.Dexter@anthonynolan.org — Tue, 02 Jun 2026 14:22:09 GMT

Pre-Malignant Conditions

Tania.Dexter@anthonynolan.org — Tue, 02 Jun 2026 14:19:05 GMT

UTERINE HYPERPLASIA

Haemoglobin Disorder

Tania.Dexter@anthonynolan.org — Tue, 02 Jun 2026 12:30:43 GMT

Acceptable if haemoglobin is within normal sex-adjusted range

Transsexual

Frances.Sarkari@anthonynolan.org — Wed, 20 May 2026 14:39:39 GMT

Guidance

Transgender

Frances.Sarkari@anthonynolan.org — Wed, 20 May 2026 14:38:15 GMT

@@ Line 1,226: / Line 1,226: @@
 Polyarteritis Nodosa, See [[Vasculitis]]
-[[Polycystic Ovarian Syndrome]]
+[[Polyendocrine metabolic ovarian syndrome]]
 [[Polycythaemia]]

← Older revision		Revision as of 15:17, 11 June 2026
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		+	PAGE OBSOLETE - PLEASE REFER TO [[Polyendocrine metabolic ovarian syndrome]]
		+
	==Acceptability at Recruitment==		==Acceptability at Recruitment==
	ACCEPTABLE		ACCEPTABLE

← Older revision		Revision as of 10:59, 10 June 2026
Line 522:		Line 522:

	[[Epstein-Barr Virus]]		[[Epstein-Barr Virus]]
		+
		+	Erb's Palsy, See [[Limb Difference]]

	ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]		ERPC (Evacuation Of Retained Products Of Conception), See [[Surgery]]

← Older revision		Revision as of 10:35, 10 June 2026
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	[[Lichen Sclerosus]]		[[Lichen Sclerosus]]
		+
		+	[[Limb Difference]]

	[[Lipoma]]		[[Lipoma]]

← Older revision		Revision as of 14:22, 2 June 2026
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	Uterine Fibroid, See [[Fibroids]]		Uterine Fibroid, See [[Fibroids]]
		+
		+	Uterine Hyperplasia, See [[Pre-Malignant Conditions]]

	Uveitis, See [[Eye Disease]]		Uveitis, See [[Eye Disease]]

@@ Line 9: / Line 9: @@
 ==Explanation of Condition==
-Disorder of female sex hormone regulation leading to multiple cysts forming within the ovaries, as well as development of some male sexual characteristics, such as facial hair. May be treated with metformin.
+Previously known as PCOS or polycystic ovary syndrome.
-See also [https://en.wikipedia.org/wiki/Polyendocrine_metabolic_ovarian_syndrome]
+Genealogical disorder of female sex hormone regulation leading to multiple cysts forming within the ovaries, as well as development of some male sexual characteristics, such as facial hair. May be treated with metformin.
 ==Guidance==
@@ Line 19: / Line 21: @@
 ==Pseudonyms or Related Conditions==
-PCOS
+PMOS
 ==Version==

@@ Line 1: / Line 1: @@
 ==Acceptability at Recruitment==
-ACCEPTED - donor must be informed that they may require a central line at donation.
+ACCEPTED - donor must be informed that they may require a central line at donation - for upper limb differences only.
 https://www.anthonynolan.org/donation-journey/peripheral-blood-stem-cell-pbsc-donation/having-a-central-line
 ==Acceptability at VT / Work-Up==
-At VT Consider cause and discuss with medical team.
+At VT consider cause and discuss with medical team.
 At work up - on a case by case basis in discussion with collection centre.
 Donor should be made aware that they may not be able to proceed depending on review at medical appointment.
 ==Individual at Risk==

@@ Line 44: / Line 44: @@
+*
 * Inform TC if under a screening/surveillance programme
 ==Version==

@@ Line 31: / Line 31: @@
 Sickle cell trait
-HbC, HbDPunjab/Oman, HbE traits
+HbC, HbDPunjab/Oman, HbE traits or raised HbF%
 Other asymptomatic traits or  compound haemoglobinopathies e.g. HbC/a-thal trait.
 There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only.
 ==Pseudonyms or Related Conditions==

← Older revision		Revision as of 14:39, 20 May 2026
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	Transgender people are not excluded from joining the Anthony Nolan register. Potential donors who would like to join the register should record their self-identified gender in the ‘male / female’ check-boxes on the application form.		Transgender people are not excluded from joining the Anthony Nolan register. Potential donors who would like to join the register should record their self-identified gender in the ‘male / female’ check-boxes on the application form.
		+
		+	Please also see the [[considerations for transgender and gender non-binary individuals]] page for more information on transgender donors.

	The sex of a potential donor is one of the factors that clinicians consider when identifying the best donor for their particular patient. Therefore, at the point of joining the register, should a potential donor voluntarily disclose that their self-identified gender is different to their sex assigned at birth, we will ask permission to record this on the application form.		The sex of a potential donor is one of the factors that clinicians consider when identifying the best donor for their particular patient. Therefore, at the point of joining the register, should a potential donor voluntarily disclose that their self-identified gender is different to their sex assigned at birth, we will ask permission to record this on the application form.

← Older revision	Revision as of 14:38, 20 May 2026
(One intermediate revision by the same user not shown)
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−	+	Please see the [[Considerations for transgender and gender non-binary individuals]] page.