Bleeding Disorder - Revision history

Ellouise.Bishop@anthonynolan.org: /* Guidance */

2026-10-29T18:10:22Z

Guidance

← Older revision		Revision as of 18:10, 29 October 2026
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	Assess the donor for personal and family history of excessive bleeding and bruising:		Assess the donor for personal and family history of excessive bleeding and bruising:

	''*Do you have any bleeding symptoms such as frequent nose bleeds, bleeding from the back passage or bleeding from the gums?		*Do you have any bleeding symptoms such as frequent nose bleeds, bleeding from the back passage or bleeding from the gums?
	*Have you ever consulted a doctor or received treatment for prolonged or unusual bleeding e.g. with nosebleeds or minor wounds?		*Have you ever consulted a doctor or received treatment for prolonged or unusual bleeding e.g. with nosebleeds or minor wounds?
	*Do you experience bruises/haematomas larger than 2cm without trauma, or severe bruising after minor trauma?		*Do you experience bruises/haematomas larger than 2cm without trauma, or severe bruising after minor trauma?
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	If assigned female at birth:		If assigned female at birth:
	*Have you ever consulted a doctor or received treatment for heavy or prolonged menstrual periods (contraceptive pill, iron etc.)?		*Have you ever consulted a doctor or received treatment for heavy or prolonged menstrual periods (contraceptive pill, iron etc.)?
	*Have you given birth - If yes - Did you experience prolonged or excessive bleeding after delivery?''		*Have you given birth - If yes - Did you experience prolonged or excessive bleeding after delivery?

	If the history is reassuring, repeat the coagulation screen with relevant factor levels as spurious results can occur.		If the history is reassuring, repeat the coagulation screen with relevant factor levels as spurious results can occur.

Ellouise.Bishop@anthonynolan.org: /* Guidance */

2026-10-29T18:09:36Z

Guidance

← Older revision		Revision as of 18:09, 29 October 2026
Line 55:		Line 55:
	Assess the donor for personal and family history of excessive bleeding and bruising:		Assess the donor for personal and family history of excessive bleeding and bruising:

	*Do you have any bleeding symptoms such as frequent nose bleeds, bleeding from the back passage or bleeding from the gums?		''*Do you have any bleeding symptoms such as frequent nose bleeds, bleeding from the back passage or bleeding from the gums?
	*Have you ever consulted a doctor or received treatment for prolonged or unusual bleeding e.g. with nosebleeds or minor wounds?		*Have you ever consulted a doctor or received treatment for prolonged or unusual bleeding e.g. with nosebleeds or minor wounds?
	*Do you experience bruises/haematomas larger than 2cm without trauma, or severe bruising after minor trauma?		*Do you experience bruises/haematomas larger than 2cm without trauma, or severe bruising after minor trauma?
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	If assigned female at birth:		If assigned female at birth:
	*Have you ever consulted a doctor or received treatment for heavy or prolonged menstrual periods (contraceptive pill, iron etc.)?		*Have you ever consulted a doctor or received treatment for heavy or prolonged menstrual periods (contraceptive pill, iron etc.)?
	*Have you given birth - If yes - Did you experience prolonged or excessive bleeding after delivery?		*Have you given birth - If yes - Did you experience prolonged or excessive bleeding after delivery?''

	If the history is reassuring, repeat the coagulation screen with relevant factor levels as spurious results can occur.		If the history is reassuring, repeat the coagulation screen with relevant factor levels as spurious results can occur.

Ellouise.Bishop@anthonynolan.org: /* Date of Last Update */

2026-10-29T18:09:08Z

Date of Last Update

← Older revision		Revision as of 18:09, 29 October 2026
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	====Date of Last Update====		====Date of Last Update====
	24th June 2026		24th June 2026

	29th October 2029		29th October 2029

Ellouise.Bishop@anthonynolan.org: /* Explanation of Condition */

2026-10-29T18:08:56Z

Explanation of Condition

← Older revision		Revision as of 18:08, 29 October 2026
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	Some deficiencies cause significant bleeding, either spontaneously or in response to even minimal trauma or minor procedures. Individuals will have been assessed and advised about their condition and bleeding risk. They may have received treatment or been told in the future they would need prophylactic treatment for surgery, dental treatments or any other procedures.		Some deficiencies cause significant bleeding, either spontaneously or in response to even minimal trauma or minor procedures. Individuals will have been assessed and advised about their condition and bleeding risk. They may have received treatment or been told in the future they would need prophylactic treatment for surgery, dental treatments or any other procedures.


	==Guidance==		==Guidance==

Ellouise.Bishop@anthonynolan.org at 18:07, 29 October 2026

2026-10-29T18:07:50Z

← Older revision		Revision as of 18:07, 29 October 2026
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	==Acceptability at Recruitment==		==Acceptability at Recruitment==
	~~UNACCEPTABLE~~		QUALIFIED

	==Acceptability at VT / Work-Up==		==Acceptability at VT / Work-Up==
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	==Explanation of Condition==		==Explanation of Condition==
	~~Most haemophilias~~ are inherited disorders of blood clotting. They may be of varying severity, but generally prohibit bone marrow donation.		Haemophilias are a rare group of mostly inherited/genetic disorders that prevents blood from clotting normally due to a lack of specific blood-clotting proteins (clotting factors). They may be of varying severity, but generally prohibit bone marrow donation. Individuals can have the disease or be a carrier (also known as trait). There are also some haemophilias that are acquired during life, and may be transient.


			Some deficiencies cause significant bleeding, either spontaneously or in response to even minimal trauma or minor procedures. Individuals will have been assessed and advised about their condition and bleeding risk. They may have received treatment or been told in the future they would need prophylactic treatment for surgery, dental treatments or any other procedures.

	~~Some haemophilias are acquired during life, and may be transient.~~

	==Guidance==		==Guidance==
			'''At Recruitment'''

			UNACCEPTABLE - Diagnosis of haemophilia A (Factor VIII deficiency), haemophilia B (Factor IX deficiency), type 2 von Willebrand disease, type 3 von Willebrand disease.

			QUALIFIED - Carriers may join the register if:
			# Have never had any excessive bleeding or bruising, and
			# Have never received any treatment to reduce or prevent excessive bleeding, and
			# Is not requiring monitoring or follow-up, accept.


			'''At CT / Work-up '''

	~~=== Guidance at VT ===~~
	Discuss with medical officer.		Discuss with medical officer.


	<b> For known history: </b>		<b> For known history: </b>

	~~Unacceptable if history~~ of ~~excessive spontaneous or provoked~~ bleeding, or ~~laboratory demonstrated severe or moderate haemophilia (including asymptomatic~~ factor XI deficiency).		Establish what type of bleeding disorder or specific coagulation factor deficiency donor has (or is a carrier of).

	~~Female carriers of~~ haemophilia A ~~and~~ B ~~should be discussed with medical officer. Consider for PBSC only if bleeding risk thought to be negligeable and after liaison with haemophilia centre.~~		Must not donate if diagnosed with haemophilia A (Factor VIII deficiency), haemophilia B (Factor IX deficiency), asymptomatic factor XI deficiency

	~~Not for central venous catheter insertion or bone marrow harvest~~.		3 types of von Willebrand disease: only donors with type 1 are potentially eligible, Type 2 and 3 are more severe and unacceptable.

	Any degree of factor XII deficiency is acceptable as long as there is no history of thrombosis.		Any degree of factor XII deficiency is acceptable as long as there is no history of thrombosis.


			Carriers should be discussed with medical officer. They can be considered for PBSC if they fulfil following criteria:
			* Has not received a transfusion since 1 January 1980, and
			* Has never received any type of coagulation factor treatment, and
			* Has never received any other treatment to reduce or prevent excessive bleeding, and
			* Has not received or been advised that they will require prophylactic treatment, and
			* Has never had any excessive bleeding or bruising, and
			* Is not requiring monitoring or follow-up, and
			* The underlying cause and/or treatment does not preclude donation, accept.


	<b> For newly identified clotting abnormalities at medical: </b>		<b> For newly identified clotting abnormalities at medical: </b>

	Assess the donor for personal and family history of excessive bleeding and bruising.		Assess the donor for personal and family history of excessive bleeding and bruising:

	*Do you have any bleeding symptoms such as frequent nose bleeds, bleeding from the back passage or bleeding from the gums?		*Do you have any bleeding symptoms such as frequent nose bleeds, bleeding from the back passage or bleeding from the gums?
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	Platelet Disorder		Platelet Disorder
	==Version==		==Version==
	Version 2, Edition 1		Version 2, Edition 2

	====Date of Last Update====		====Date of Last Update====
	24th June 2026		24th June 2026
			29th October 2029

Natalie.Murray@anthonynolan.org: /* Date of Last Update */

2026-06-24T10:40:23Z

Date of Last Update

← Older revision		Revision as of 10:40, 24 June 2026
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	====Date of Last Update====		====Date of Last Update====
	~~24TH~~ June 2026		24th June 2026

Natalie.Murray@anthonynolan.org at 09:39, 24 June 2026

2026-06-24T09:39:14Z

← Older revision		Revision as of 09:39, 24 June 2026
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	==Acceptability at Recruitment==		==Acceptability at Recruitment==
	~~QUALIFIED~~		UNACCEPTABLE

	==Acceptability at VT / Work-Up==		==Acceptability at VT / Work-Up==
Line 63:		Line 63:
	Platelet Disorder		Platelet Disorder
	==Version==		==Version==
	Version 1, Edition 2		Version 2, Edition 1

	====Date of Last Update====		====Date of Last Update====
			24TH June 2026

Natalie.Murray@anthonynolan.org: /* Version */

2026-06-24T09:34:54Z

Version

← Older revision		Revision as of 09:34, 24 June 2026
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	Platelet Disorder		Platelet Disorder
	==Version==		==Version==
	Version 2, Edition 1		Version 1, Edition 2

	====Date of Last Update====		====Date of Last Update====
	~~24th June 2026~~

Natalie.Murray@anthonynolan.org: /* Acceptability at Recruitment */

2026-06-24T09:34:40Z

Acceptability at Recruitment

← Older revision		Revision as of 09:34, 24 June 2026
Line 1:		Line 1:
	==Acceptability at Recruitment==		==Acceptability at Recruitment==
	~~UNACCEPTABLE~~		QUALIFIED

	==Acceptability at VT / Work-Up==		==Acceptability at VT / Work-Up==

Natalie.Murray@anthonynolan.org at 09:31, 24 June 2026

2026-06-24T09:31:32Z

← Older revision		Revision as of 09:31, 24 June 2026
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	==Acceptability at Recruitment==		==Acceptability at Recruitment==
	~~QUALIFIED~~		UNACCEPTABLE

	==Acceptability at VT / Work-Up==		==Acceptability at VT / Work-Up==
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	==Guidance==		==Guidance==

	~~=== Guidance at recruitment ===~~

	~~Acceptable~~

	=== Guidance at VT ===		=== Guidance at VT ===
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	Platelet Disorder		Platelet Disorder
	==Version==		==Version==
	Version 1, Edition 2		Version 2, Edition 1

	====Date of Last Update====		====Date of Last Update====
	~~17th September 2025~~		24th June 2026