Coronavirus - Revision history

Ruta.Maniusyte@anthonynolan.org: /* Pseudonyms or Related Conditions */

2022-08-26T12:45:24Z

Pseudonyms or Related Conditions

← Older revision		Revision as of 12:45, 26 August 2022
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	'''5)''' '''Donor with a positive antibody test:''' requires confirmation with PCR or LFT test.		'''5)''' '''Donor with a positive antibody test:''' requires confirmation with PCR or LFT test.

	~~==Pseudonyms or Related Conditions==~~
	==Version==		==Version==
	Version 3, Edition 1		Version 3, Edition 1
	Date of Last Update		Date of Last Update
	17 August 2022		17 August 2022

Ruta.Maniusyte@anthonynolan.org: /* Version */

2022-08-26T12:44:32Z

Version

← Older revision		Revision as of 12:44, 26 August 2022
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	==Pseudonyms or Related Conditions==		==Pseudonyms or Related Conditions==
	==Version==		==Version==
	Version 2, Edition 2		Version 3, Edition 1
	Date of Last Update		Date of Last Update
	~~27 September 2021~~		17 August 2022

Ruta.Maniusyte@anthonynolan.org at 12:25, 18 August 2022

2022-08-18T12:25:38Z

← Older revision		Revision as of 12:25, 18 August 2022
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	QUALIFIED according to following conditions:		QUALIFIED according to following conditions:

	- If donor is '''COVID19 PCR or LFT positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and ~~according to the policy of~~ the agency ~~used to collect~~ blood samples		- If donor is '''COVID19 PCR or LFT positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and adequate time period has passed that is required by the agency that collects blood samples

	- If donor has '''COVID19 symptoms''' but no positive test result, advise to seek testing and defer until symptom resolution or time period ~~in accordance to~~ the agency who collect blood samples has passed		- If donor has '''COVID19 symptoms''' but no positive test result, advise to seek testing and defer until symptom resolution or time period required by the agency who collect blood samples has passed

	- If donor had '''COVID19 exposure''', donor can proceed. If donor tests positive or develops symptoms at any stage, please follow the advice for COVID19 ~~PCR~~ positive/symptomatic donor		- If donor had '''COVID19 exposure''', donor can proceed. If donor tests positive or develops symptoms at any stage, please follow the advice for COVID19 positive/symptomatic donor

	==Acceptability at Work-Up and for CGT==		==Acceptability at Work-Up and for CGT==
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	'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR or LFT test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''		'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR or LFT test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
	If at least 14 days have passed since the resolution of symptoms (despite donor's vaccination status) and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within 28 days of resolution of symptoms. If less than 24 days have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 24 days.		If at least 14 days have passed since the resolution of symptoms (despite donor's vaccination status) and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within 14 days of resolution of symptoms. If less than 14 days have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 14 days.

	'''4)''' '''Donor shares household with a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 14 days passed from the last contact with the individual with confirmed or suspected Coronavirus infection despite their vaccination status. If less than 14 days have passed since the last contact with the individual or if the exposure is less significant than household contact and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 10 days.		'''4)''' '''Donor shares household with a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 14 days passed from the last contact with the individual with confirmed or suspected Coronavirus infection despite their vaccination status. If less than 14 days have passed since the last contact with the individual or if the exposure is less significant than household contact and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 10 days.

Ruta.Maniusyte@anthonynolan.org at 12:21, 18 August 2022

2022-08-18T12:21:21Z

Ruta.Maniusyte@anthonynolan.org at 11:17, 4 October 2021

2021-10-04T11:17:39Z

← Older revision		Revision as of 11:17, 4 October 2021
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	==Pseudonyms or Related Conditions==		==Pseudonyms or Related Conditions==
	==Version==		==Version==
	Version 1, Edition 1		Version 2, Edition 2
	Date of Last Update		Date of Last Update
	~~20 February 2020~~		27 September 2021

Ruta.Maniusyte@anthonynolan.org at 08:37, 27 September 2021

2021-09-27T08:37:30Z

← Older revision		Revision as of 08:37, 27 September 2021
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	==Acceptability at Recruitment and VT stage==		==Acceptability at Recruitment and VT stage==
	QUALIFIED according to following conditions:		QUALIFIED according to following conditions:

	- If donor is '''COVID19 PCR positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and at least 10 days have passed since the diagnosis		- If donor is '''COVID19 PCR positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and at least 10 days have passed since the diagnosis

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	'''JPAC definition of symptom resolution:'''		'''JPAC definition of symptom resolution:'''
	• Donors can be considered to have recovered if they:
			Donors can be considered to have recovered if they:

	• Are generally well and back to normal activities		• Are generally well and back to normal activities

	• Do not have continuing fatigue which affects daily activities		• Do not have continuing fatigue which affects daily activities

	• Do not have a fever		• Do not have a fever

	• Do not have respiratory symptoms (except for a persistent mild cough)		• Do not have respiratory symptoms (except for a persistent mild cough)

	• Are not experiencing cardiac symptoms (e.g. chest pain, palpitations)		• Are not experiencing cardiac symptoms (e.g. chest pain, palpitations)
	• Are not experiencing any other symptoms e.g. peripheral neurological symptoms in upper or lower limbs, central neurological symptoms such as headache, dizziness.
			• Are not experiencing any other symptoms e.g. peripheral neurological symptoms in upper or lower limbs, central neurological symptoms such as headache, dizziness

	• Some individuals may have a cough or reduced sense of smell or taste for some weeks after resolution of their infection, but can be considered as recovered for the purposes of tissue and cell donation.		• Some individuals may have a cough or reduced sense of smell or taste for some weeks after resolution of their infection, but can be considered as recovered for the purposes of tissue and cell donation.

	'''Fully vaccinated''' is defined as:		'''Fully vaccinated''' is defined as:

	• 14 days have passed since the 2nd dose of vaccine		• 14 days have passed since the 2nd dose of vaccine
	• Donor is above 18 years old		• Donor is above 18 years old

	'''Concessionary release/ non-conformatory''' needs to be raised only if:		'''Concessionary release/ non-conformatory''' needs to be raised only if:

	• Donor is donating in less than 28 days from symptom resolution or diagnosis (depending on which is later).		• Donor is donating in less than 28 days from symptom resolution or diagnosis (depending on which is later).

Ruta.Maniusyte@anthonynolan.org at 08:34, 27 September 2021

2021-09-27T08:34:13Z

← Older revision		Revision as of 08:34, 27 September 2021
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	==Acceptability at Recruitment==		==Acceptability at Recruitment and VT stage==
	QUALIFIED		QUALIFIED according to following conditions:
	==Acceptability at ~~CT /~~ Work-Up==		- If donor is '''COVID19 PCR positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and at least 10 days have passed since the diagnosis
	QUALIFIED
			- If donor has '''COVID19 symptoms''' but no positive test result, advise to seek testing and defer until symptom resolution and at least 10 days have passed since the initial development of symptoms

			- If donor had '''COVID19 exposure''' and has been '''fully vaccinated''', donor can proceed. If donor tests positive or develops symptoms at any stage, please follow the advice for COVID19 PCR positive/symptomatic donor

			- If '''COVID19 exposure''' and '''NOT fully vaccinated''' with, defer for 10 days. If donor tests positive or develops symptoms at any stage, please follow the advice for COVID19 PCR positive donor.

			==Acceptability at Work-Up and for CGT==
			QUALIFIED under the following conditions:

			- If donor is '''COVID19 PCR positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and at least '''28 days''' have passed since the diagnosis until donor receives GCSF or general anaesthetic for bone marrow harvest. In such cases, there is no need for concessionary release forms to be raised. Donor can '''attend medical''' once at least '''10 days''' have passed since the diagnosis (despite the vaccination status) and provided they are feeling well enough to attend the medical. However, if the transplant is extremely urgent or there are severe scheduling issues, please discuss with MO. In such cases concessionary release forms will need to be completed.

			- If donor has '''COVID19 symptoms''', advise to obtain COVID19 PCR test and if develops symptoms to seek medical help as per usual NHS advice. If donor tests positive, please follow COVID19 PCR positive donor advice, if tests negative – discuss with MO as case by case discussion is required.

			- If donor’s '''household member''' has PCR '''confirmed COVID19 diagnosis''', please follow the COVID19 PCR positive donor advice despite donor’s vaccination status.

			- If donor had '''exposure to non-household contact''' who are either potentially positive for COVID19 or have confirmed COVID19 diagnosis, this will require case by case discussion with MO.

	==Individual at Risk==		==Individual at Risk==
	Recipient		Donor/ Recipient
			==Definitions==

			'''JPAC definition of symptom resolution:'''
			• Donors can be considered to have recovered if they:
			• Are generally well and back to normal activities
			• Do not have continuing fatigue which affects daily activities
			• Do not have a fever
			• Do not have respiratory symptoms (except for a persistent mild cough)
			• Are not experiencing cardiac symptoms (e.g. chest pain, palpitations)
			• Are not experiencing any other symptoms e.g. peripheral neurological symptoms in upper or lower limbs, central neurological symptoms such as headache, dizziness.
			• Some individuals may have a cough or reduced sense of smell or taste for some weeks after resolution of their infection, but can be considered as recovered for the purposes of tissue and cell donation.

			'''Fully vaccinated''' is defined as:
			• 14 days have passed since the 2nd dose of vaccine
			• Donor is above 18 years old

			'''Concessionary release/ non-conformatory''' needs to be raised only if:
			• Donor is donating in less than 28 days from symptom resolution or diagnosis (depending on which is later).

	==Explanation of Condition==		==Explanation of Condition==
	Viral infection that can cause diseases in mammal and birds. In humans, common coronaviruses cause colds and respiratory tract infections but are not considered a risk for transfusion recipients. Since 2002 there have been outbreaks in humans of new strains of coronavirus, associated with severe pulmonary infections and mortality rates of 10-35% e.g. SARS and MERS. There is no evidence at present that coronaviruses can be transmitted by blood transfusion or tissue/cell transplantation and therefore these measures are precautionary.		Viral infection that can cause diseases in mammal and birds. In humans, common coronaviruses cause colds and respiratory tract infections but are not considered a risk for transfusion recipients. Since 2002 there have been outbreaks in humans of new strains of coronavirus, associated with severe pulmonary infections and mortality rates of 10-35% e.g. SARS and MERS. There is no evidence at present that coronaviruses can be transmitted by blood transfusion or tissue/cell transplantation and therefore these measures are precautionary.
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	==Guidance==		==Guidance==
	'''1)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and history of one or more symptoms of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''		'''1)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and history of one or more symptoms of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
	Must not donate within ~~3 months~~ of resolution of symptoms. If less than ~~3 months~~ have passed since resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than ~~3 months~~.		Must not donate within 28 days of resolution of symptoms. If less than 28 days have passed since resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days.

	'''2)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and no history of symptoms of Coronavirus infection as per the UK GOV definition:'''		'''2)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and no history of symptoms of Coronavirus infection as per the UK GOV definition:'''
	Must not donate within ~~3 months~~ of positive result by diagnostic test. If less than ~~3 months~~ have passed since positive result by diagnostic test and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than ~~3 months~~.		Must not donate within 28 days of positive result by diagnostic test. If less than 28 days have passed since positive result by diagnostic test and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days.

	'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''		'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
	If ~~more than 14~~ days have passed since resolution of symptoms and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within ~~3 months~~ of resolution of symptoms. If less than ~~3 months~~ have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than ~~3 months~~.		If at least 10 days have passed since the resolution of symptoms (despite donor's vaccination status) and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within 28 days of resolution of symptoms. If less than 28 days have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days.

	'''4)''' '''Donor is a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 28 days from last contact with the individual with confirmed or suspected Coronavirus infection. If less than 28 days have passed since last contact with the individual and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days~~. Healthcare workers should be referred to the MO for an individual risk assessment~~.		'''4)''' '''Donor shares household with a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 10 days passed from the last contact with the individual with confirmed or suspected Coronavirus infection despite their vaccination status. If less than 10 days have passed since the last contact with the individual or if the exposure is less significant than household contact and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 10 days.

	'''5)''' '''Donor with a positive antibody test:''' This is managed case by case. Donors should be referred to the MO for an individual risk assessment.		'''5)''' '''Donor with a positive antibody test:''' requires confirmation with PCR test. This is managed case by case. Donors should be referred to the MO for an individual risk assessment.

	==Pseudonyms or Related Conditions==		==Pseudonyms or Related Conditions==

Rosalina.Naidoo@anthonynolan.org: /* Guidance */

2020-07-13T00:15:50Z

Guidance

← Older revision		Revision as of 00:15, 13 July 2020
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	==Guidance==		==Guidance==
	Must not donate ~~if:~~		'''1)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and history of one or more symptoms of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
	~~a) Less~~ than ~~28 days from a donor’s return from~~ a ~~Coronavirus~~ risk ~~area. This includes transit through an airport in a Coronavirus risk area, even if the traveller has not left the airport~~.		Must not donate within 3 months of resolution of symptoms. If less than 3 months have passed since resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 3 months.

	b) ~~Less~~ than ~~28 days from~~ the ~~last contact with~~ a ~~person with Coronavirus infection~~.		'''2)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and no history of symptoms of Coronavirus infection as per the UK GOV definition:'''
			Must not donate within 3 months of positive result by diagnostic test. If less than 3 months have passed since positive result by diagnostic test and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 3 months.

	c) ~~Less~~ than 28 days since ~~recovery from Coronavirus~~ infection ~~or possible~~ Coronavirus ~~infection~~.		'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
			If more than 14 days have passed since resolution of symptoms and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within 3 months of resolution of symptoms. If less than 3 months have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 3 months.

	~~Discretionary~~:		'''4)''' '''Donor is a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 28 days from last contact with the individual with confirmed or suspected Coronavirus infection. If less than 28 days have passed since last contact with the individual and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days. Healthcare workers should be referred to the MO for an individual risk assessment.

	~~If more than 28 days has passed since:~~		'''5)''' '''Donor with a positive antibody test:''' This is managed case by case. Donors should be referred to the MO for an individual risk assessment.
	~~• returning from a Coronavirus risk area, and/or~~
	~~• last contact~~ with a ~~person affected~~ by ~~Coronavirus, and/or~~
	~~• recovery from proven or presumed Coronavirus infection~~
	~~and the donor has remained well, accept~~.

	~~If less than 28 days has passed since returning from a Coronavirus risk area, or from~~ the last contact with a person affected by Coronavirus, or since recovery from Coronavirus infection or possible Coronavirus infection, refer to designated clinical support officer. Donor may be accepted with individual risk assessment ~~subject to expert microbiological advice~~.

	==Pseudonyms or Related Conditions==		==Pseudonyms or Related Conditions==

Dave.Vernon@anthonynolan.org at 15:28, 2 July 2020

2020-07-02T15:28:28Z

← Older revision		Revision as of 15:28, 2 July 2020
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	~~Coronavirus~~

	==Acceptability at Recruitment==		==Acceptability at Recruitment==
	QUALIFIED		QUALIFIED

Servicedesk: Created page with "Coronavirus ==Acceptability at Recruitment== QUALIFIED ==Acceptability at CT / Work-Up== QUALIFIED ==Individual at Risk== Recipient ==Explanation of Condition== Viral inf..."

2020-02-25T15:51:48Z

Created page with "Coronavirus ==Acceptability at Recruitment== QUALIFIED ==Acceptability at CT / Work-Up== QUALIFIED ==Individual at Risk== Recipient ==Explanation of Condition== Viral inf..."

New page

Coronavirus

==Acceptability at Recruitment==
QUALIFIED
==Acceptability at CT / Work-Up==
QUALIFIED
==Individual at Risk==
Recipient
==Explanation of Condition==
Viral infection that can cause diseases in mammal and birds. In humans, common coronaviruses cause colds and respiratory tract infections but are not considered a risk for transfusion recipients. Since 2002 there have been outbreaks in humans of new strains of coronavirus, associated with severe pulmonary infections and mortality rates of 10-35% e.g. SARS and MERS. There is no evidence at present that coronaviruses can be transmitted by blood transfusion or tissue/cell transplantation and therefore these measures are precautionary.
See also Coronavirus

==Guidance==
Must not donate if:
a) Less than 28 days from a donor’s return from a Coronavirus risk area. This includes transit through an airport in a Coronavirus risk area, even if the traveller has not left the airport.

b) Less than 28 days from the last contact with a person with Coronavirus infection.

c) Less than 28 days since recovery from Coronavirus infection or possible Coronavirus infection.

Discretionary:

If more than 28 days has passed since:
• returning from a Coronavirus risk area, and/or
• last contact with a person affected by Coronavirus, and/or
• recovery from proven or presumed Coronavirus infection
and the donor has remained well, accept.

If less than 28 days has passed since returning from a Coronavirus risk area, or from the last contact with a person affected by Coronavirus, or since recovery from Coronavirus infection or possible Coronavirus infection, refer to designated clinical support officer. Donor may be accepted with individual risk assessment subject to expert microbiological advice.

==Pseudonyms or Related Conditions==
==Version==
Version 1, Edition 1
Date of Last Update
20 February 2020

← Older revision		Revision as of 12:21, 18 August 2022
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	==Acceptability at Recruitment and VT stage==		==Acceptability at Recruitment==
			All donors with present or past COVID-19 infection are accepted. Please note on donor's file to check at later stage if matched to check if no long-COVID-19 symptoms are present and if fully recovered.

			==Acceptability at VT stage==
	QUALIFIED according to following conditions:		QUALIFIED according to following conditions:

	- If donor is '''COVID19 PCR positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and ~~at least 10 days have passed since the diagnosis~~		- If donor is '''COVID19 PCR or LFT positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and according to the policy of the agency used to collect blood samples

	~~- If donor has '''COVID19 symptoms''' but no positive test result, advise~~ to ~~seek testing and defer until symptom resolution and at least 10 days have passed since~~ the ~~initial development~~ of ~~symptoms~~

	- If donor ~~had~~ '''COVID19 ~~exposure~~''' and ~~has been '''fully vaccinated''', donor can proceed. If donor tests positive~~ or ~~develops symptoms at any stage, please follow~~ the ~~advice for COVID19 PCR positive/symptomatic donor~~		- If donor has '''COVID19 symptoms''' but no positive test result, advise to seek testing and defer until symptom resolution or time period in accordance to the agency who collect blood samples has passed

	- If '''COVID19 exposure''' ~~and '''NOT fully vaccinated''' with~~, ~~defer for 10 days~~. If donor tests positive or develops symptoms at any stage, please follow the advice for COVID19 PCR positive donor.		- If donor had '''COVID19 exposure''', donor can proceed. If donor tests positive or develops symptoms at any stage, please follow the advice for COVID19 PCR positive/symptomatic donor

	==Acceptability at Work-Up and for CGT==		==Acceptability at Work-Up and for CGT==
	QUALIFIED under the following conditions:		QUALIFIED under the following conditions:

	- If donor is '''COVID19 PCR positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and at least '''28 days''' have passed since the diagnosis until donor receives GCSF or general anaesthetic for bone marrow harvest. In such cases, there is no need for concessionary release forms to be raised. Donor can '''attend medical''' ~~once at least '''10 days''' have passed since~~ the ~~diagnosis (despite the vaccination status)~~ and provided they are feeling well enough to attend the medical. However, if the transplant is extremely urgent or there are severe scheduling issues, please discuss with MO. In such cases concessionary release forms will need to be completed.		- If donor is '''COVID19 PCR or LFT positive''', await resolution of symptoms (see JPAC guidelines on definition of symptom resolution) and at least '''14 days''' have passed since the diagnosis until donor receives GCSF or '''7 weeks''' have passed from diagnosis to the general anaesthetic for bone marrow harvest. In such cases, there is no need for concessionary release forms to be raised. Donor can '''attend medical''' based on the local collection centre rules and provided they are feeling well enough to attend the medical. However, if the transplant is extremely urgent or there are severe scheduling issues, please discuss with MO. In such cases concessionary release forms will need to be completed.

	- If donor has '''COVID19 symptoms''', advise to obtain COVID19 PCR test and if develops symptoms to seek medical help as per usual NHS advice. If donor tests positive, please follow COVID19 ~~PCR~~ positive donor advice, if tests negative – discuss with MO as case by case discussion is required.		- If donor has '''COVID19 symptoms''', advise to obtain COVID19 PCR or LFT test and if develops symptoms to seek medical help as per usual NHS advice. If donor tests positive, please follow COVID19 positive donor advice, if tests negative – discuss with MO as case by case discussion is required.

	- If donor’s '''household member''' has PCR '''confirmed COVID19 diagnosis''', please follow the COVID19 ~~PCR~~ positive donor advice despite donor’s vaccination status.		- If donor’s '''household member''' has PCR or LFT '''confirmed COVID19 diagnosis''', please follow the COVID19 positive donor advice despite donor’s vaccination status.

	- If donor had '''exposure to non-household contact''' who are either potentially positive for COVID19 or have confirmed COVID19 diagnosis, this will require case by case discussion with MO.		- If donor had '''exposure to non-household contact''' who are either potentially positive for COVID19 or have confirmed COVID19 diagnosis, this will require case by case discussion with MO.
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	'''Concessionary release/ non-conformatory''' needs to be raised only if:		'''Concessionary release/ non-conformatory''' needs to be raised only if:

	• Donor is donating in less than 28 days from symptom resolution or diagnosis (depending on which is later).		• Donor is donating in less than 14 days from symptom resolution or diagnosis (depending on which is later).

	==Explanation of Condition==		==Explanation of Condition==
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	==Guidance==		==Guidance==
	'''1)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and history of one or more symptoms of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''		'''1)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR or LFT test and history of one or more symptoms of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
	Must not donate within 28 days of resolution of symptoms. If less than 28 days have passed since resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days.		Must not donate within 14 days of resolution of symptoms. If less than 14 days have passed since resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 14 days.

	'''2)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR test and no history of symptoms of Coronavirus infection as per the UK GOV definition:'''		'''2)''' '''Donor with confirmed Coronavirus infection on diagnostic PCR or LFT test and no history of symptoms of Coronavirus infection as per the UK GOV definition:'''
	Must not donate within 28 days of positive result by diagnostic test. If less than 28 days have passed since positive result by diagnostic test and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days.		Must not donate within 14 days of positive result by diagnostic test. If less than 14 days have passed since positive result by diagnostic test and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 14 days.

	'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''		'''3)''' '''Donor with suspected Coronavirus infection ie. NO confirmation of infection on diagnostic PCR or LFT test, but does have a history of one or more symptoms suggestive of Coronavirus infection as per the UK GOV definition (a new persistent cough; high temperature; loss of/change in normal sense of smell or taste):'''
	If at least 10 days have passed since the resolution of symptoms (despite donor's vaccination status) and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within 28 days of resolution of symptoms. If less than 28 days have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 28 days.		If at least 14 days have passed since the resolution of symptoms (despite donor's vaccination status) and the donor has been tested and advised that they do not have coronavirus infection then accept. If the donor has never been tested and never been advised that they do not have infection with Coronavirus then they must not donate within 28 days of resolution of symptoms. If less than 24 days have passed since of resolution of symptoms and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 24 days.

	'''4)''' '''Donor shares household with a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 10 days passed from the last contact with the individual with confirmed or suspected Coronavirus infection despite their vaccination status. If less than 10 days have passed since the last contact with the individual or if the exposure is less significant than household contact and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 10 days.		'''4)''' '''Donor shares household with a contact of a confirmed or suspected case of Coronavirus infection as per definitions above:''' Must not donate if less than 14 days passed from the last contact with the individual with confirmed or suspected Coronavirus infection despite their vaccination status. If less than 14 days have passed since the last contact with the individual or if the exposure is less significant than household contact and the transplant is urgent then refer to the designated MO for a risk assessment and consideration of proceeding sooner than 10 days.

	'''5)''' '''Donor with a positive antibody test:''' requires confirmation with PCR test~~. This is managed case by case. Donors should be referred to the MO for an individual risk assessment~~.		'''5)''' '''Donor with a positive antibody test:''' requires confirmation with PCR or LFT test.

	==Pseudonyms or Related Conditions==		==Pseudonyms or Related Conditions==