Cytomegalovirus - Revision history

Maram.Ghiti@anthonynolan.org: /* Guidance at medical */

2025-07-31T13:49:44Z

Guidance at medical

Maram.Ghiti@anthonynolan.org: /* Guidance at WORK-UP */

2025-07-31T13:49:21Z

Guidance at WORK-UP

PaulM at 08:46, 16 April 2018

2018-04-16T08:46:11Z

PaulM: /* Testing outcomes and guidance */

2016-06-09T17:10:51Z

Testing outcomes and guidance

PaulM: /* Testing outcomes and guidance */

2016-06-09T17:10:34Z

Testing outcomes and guidance

PaulM: /* Testing outcomes and guidance */

2016-06-09T17:09:10Z

Testing outcomes and guidance

PaulM: /* Guidance at WORK-UP */

2016-06-09T17:08:56Z

Guidance at WORK-UP

PaulM at 17:08, 9 June 2016

2016-06-09T17:08:40Z

Dr Robert Lown: Protected "Cytomegalovirus" (‎[edit=sysop] (indefinite) ‎[move=sysop] (indefinite))

2012-06-19T11:37:47Z

Protected "Cytomegalovirus" (‎[edit=sysop] (indefinite) ‎[move=sysop] (indefinite))

Dr Robert Lown: Page created

2012-06-12T14:46:22Z

Page created

New page

==Acceptability at Recruitment==
ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED

==Individual at Risk==
Recipient

==Explanation of Condition==
Member of the herpes virus family. It may cause a mild febrile illness or be completely asymptomatic in normal individuals. However, it can cause life-threatening infection in stem-cell transplant recipients.

==Guidance==
Accept at recruitment.

Allow 2 weeks from recovery before donation if evidence of acute infection.

If identified as CMV IgM postitive at work-up, the harvest centre should request CMV DNA PCR, and the transplant centre must be informed.

==Pseudonyms or Related Conditions==
CMV

==Version==
Version 1, Edition 1

====Date of Last Update====
15th June 2012

@@ Line 20: / Line 20: @@
 ==Guidance at medical ==
-CMV-IgG and IgM should be performed at work-up. If CMV IgM is postitive, CMV-PCR should be undertaken.
+CMV-IgG and IgM should be performed at medical. If CMV IgM is postitive, CMV-PCR should be undertaken.
 ==Testing outcomes and guidance==

← Older revision		Revision as of 13:49, 31 July 2025
Line 18:		Line 18:


−	==Guidance at ~~WORK-UP~~==	+	==Guidance at medical ==

	CMV-IgG and IgM should be performed at work-up. If CMV IgM is postitive, CMV-PCR should be undertaken.		CMV-IgG and IgM should be performed at work-up. If CMV IgM is postitive, CMV-PCR should be undertaken.

@@ Line 46: / Line 46: @@
     CMV-IgM = positive and CMV-IgG = negative and CMV-PCR=negative
-Results should be referred to reference lab for confirmation
+Donor can be cleared. Inform TC.
@@ Line 55: / Line 55: @@
     CMV-PCR = positive
-Donor cannot be cleared. Inform transplant centre and discuss donor deferral
+Donor cannot be cleared. Deferred for 4-6 weeks and repeat CMV PCR then.
 ==Justification for guidance==

@@ Line 34: / Line 34: @@
 Status information should be reported to the transplant centre
-Thdonor can be cleared at workup. If there is a change of CMV status from CT to work-up stage, the transplant centre should be informed immediately.
+The donor can be cleared at workup.
 CMV-IgG weak positive results should be referred to reference lab for confirmation

@@ Line 27: / Line 27: @@
-CMV-IgM = negative, CMV-IgG = positive or negative
+   CMV-IgM = negative, CMV-IgG = positive or negative
-CMV-IgM = positive, CMV-IgG = positive, CMV-PCR negative
+   CMV-IgM = positive, CMV-IgG = positive, CMV-PCR negative
@@ Line 42: / Line 42: @@
-CMV-IgM = positive and CMV-IgG = negative and CMV-PCR=negative
+   CMV-IgM = positive and CMV-IgG = negative and CMV-PCR=negative
 Results should be referred to reference lab for confirmation
@@ Line 51: / Line 51: @@
-CMV-PCR = positive
+   CMV-PCR = positive
 Donor cannot be cleared. Inform transplant centre and discuss donor deferral

@@ Line 25: / Line 25: @@
-)
 CMV-IgM = negative, CMV-IgG = positive or negative
@@ Line 40: / Line 40: @@
-)
 CMV-IgM = positive and CMV-IgG = negative and CMV-PCR=negative
@@ Line 49: / Line 49: @@
-) CMV-PCR = positive
 ==Justification for guidance==

@@ Line 1: / Line 1: @@
-==Acceptability at Recruitment==
+==Condition==
-==Acceptability at CT / Work-Up==
+Herpesvirus causing self-limiting infection in immunocompetent individuals, but with potentially severe consequences in immuno-suppressed transplant patients.
-==Individual at Risk==
+==Individual at risk==
-==Explanation of Condition==
+Recipient
-==Guidance==
+==Guidance at RECRUITMENT==
-Accept at recruitment.
 ==Pseudonyms or Related Conditions==
@@ Line 22: / Line 76: @@
 ==Version==
-Version 1, Edition 1
+Version 2, Edition 1
 ====Date of Last Update====
-th June 2012
+June 2016

← Older revision	Revision as of 11:37, 19 June 2012
(No difference)