Epstein-Barr Virus - Revision history

Maram.Ghiti@anthonynolan.org: /* Guidance at Work-up */

2025-07-31T13:48:14Z

Guidance at Work-up

2025-06-12T09:05:18Z

Outcomes and recommended actions based on EBV serology and PCR:

2024-05-16T11:03:37Z

Outcomes and recommended actions based on EBV serology and PCR:

2024-05-16T09:15:46Z

Guidance at Work-up

2020-01-10T14:22:18Z

Outcomes and recommended actions based on EBV serology and PCR:

2020-01-10T14:21:53Z

Outcomes and recommended actions based on EBV serology and PCR:

2020-01-10T14:21:15Z

Outcomes and recommended actions based on EBV serology and PCR:

2018-11-26T17:39:39Z

Guidance at Work-up

2018-04-16T08:49:19Z

2017-11-01T09:45:19Z

Outcomes and recommended actions based on EBV serology and PCR:

@@ Line 18: / Line 18: @@
 The following serological tests should be obtained
-•	VCA-IgM
+•	VCA-IgM - if this is positive or equivocal, an EBV PCR should be obtained.
 •	VCA-IgG
@@ Line 44: / Line 44: @@
 '''
-Ideally, an EBV PCR should have been performed at medical. If not, TC discretion is used to guide whether an EBV PCR is undertaken.
+Request EBV-DNA PCR
-If an EBV PCR is not required, a concessionary release form should be completed.

@@ Line 36: / Line 36: @@
 '''
-''''Donor can be cleared - transplant centre should be informed for serological/PCR status''
+''''Donor can be cleared - transplant centre will be informed of serological status on clearance document''
 ''

← Older revision		Revision as of 11:03, 16 May 2024
Line 39:		Line 39:

	''		''
		+

	2) '''VCA-IgM-pos OR equivocal AND VCA-IgG and/or EBNA positive		2) '''VCA-IgM-pos OR equivocal AND VCA-IgG and/or EBNA positive

@@ Line 40: / Line 40: @@
 ''
-) '''VCA-IgM-pos AND VCA-IgG and/or EBNA positive
+) '''VCA-IgM-pos OR equivocal AND VCA-IgG and/or EBNA positive
 '''
-Inform the TC and proceed donation without EBV-DNA PCR
+Ideally, an EBV PCR should have been performed at medical. If not, TC discretion is used to guide whether an EBV PCR is undertaken.
-)'''VCA-IgM-pos AND VCA-IgG and/or EBNA weak or negative
+)'''VCA-IgM-pos OR equivocal AND VCA-IgG and/or EBNA weak or negative
 Request EBV-DNA PCR

@@ Line 36: / Line 36: @@
 '''
-''Donor can be cleared - transplant centre should be informed for serological/PCR status''
+''''Donor can be cleared - transplant centre should be informed for serological/PCR status''
 ) '''VCA-IgM-pos AND VCA-IgG and/or EBNA positive

@@ Line 40: / Line 40: @@
-) '''VCA-IgM-pos AND VCA-IgG and/or EBNA weak or negative
+) '''VCA-IgM-pos AND VCA-IgG and/or EBNA positive
 '''
-b) Donor has symptoms of viral infection --> Request EBV DNA PCR.
+)'''VCA-IgM-pos AND VCA-IgG and/or EBNA weak or negative
-*The clinical picture (e.g. sore throat, swollen lymph glands) as well as laboratory parameters (lymphocytosis, atypical lymphocytes on blood smear) should be correlated with serology, and taken into account for reasons of donor safety. Consider more specific immunoblots to validate the serology results.  Results should be communicated with transplant centre.''
+b) If EBV-DNA PCR positive --> inform the TC, donation will have to be postponed and EBV serology repeated after 1 month.
 ==Justification for guidance==

@@ Line 22: / Line 22: @@
 •	VCA-IgG
-•	(EBNA-IgG)
+•      (EBNA-IgG)
 ===Outcomes and recommended actions based on EBV serology and PCR:===
@@ Line 32: / Line 32: @@
-) VCA-IgM neg AND VCA-IgG pos or neg.
+) '''VCA-IgM neg AND VCA-IgG pos or neg.
 ''Donor can be cleared - transplant centre should be informed for serological/PCR status''
@@ Line 43: / Line 40: @@
-) VCA-IgM-pos AND VCA-IgG and/or EBNA weak or negative AND EBV-PCR=negative
+) '''VCA-IgM-pos AND VCA-IgG and/or EBNA weak or negative
 '''
-''Donor cannot be cleared. Inform transplant centre and repeat EBV-PCR in 4-6 weeks.
+*The clinical picture (e.g. sore throat, swollen lymph glands) as well as laboratory parameters (lymphocytosis, atypical lymphocytes on blood smear) should be correlated with serology, and taken into account for reasons of donor safety. Consider more specific immunoblots to validate the serology results.  Results should be communicated with transplant centre.''
 ==Justification for guidance==

@@ Line 47: / Line 47: @@
 ''IgM could be non-specific or donor has  acute (inapperent) infection
 The clinical picture (e.g. sore throat, swollen lymph glands) as well as laboratory parameters (lymphocytosis, atypical lymphocytes on blood smear) should be correlated with serology, and taken into account for reasons of donor safety. Consider more specific immunoblots to validate the serology results.  Results should be communicated with transplant centre.''
@@ Line 55: / Line 56: @@
-''Donor cannot be cleared at the current timepoint. Inform transplant centre and repeat EBV-PCR in one month
+''Donor cannot be cleared. Inform transplant centre and repeat EBV-PCR in 4-6 weeks.
 ==Justification for guidance==

← Older revision		Revision as of 09:45, 1 November 2017
Line 55:		Line 55:


−	''Donor cannot be cleared at the current timepoint. Inform transplant centre and repeat EBV-PCR in one month"	+	''Donor cannot be cleared at the current timepoint. Inform transplant centre and repeat EBV-PCR in one month

	==Justification for guidance==		==Justification for guidance==