https://www.med-guidelines.org.uk/index.php?action=history&feed=atom&title=Hereditary_Fructose_Intolerance 2026-05-04T16:53:40Z Revision history for this page on the wiki MediaWiki 1.34.1 https://www.med-guidelines.org.uk/index.php?title=Hereditary_Fructose_Intolerance&diff=2270&oldid=prev 2025-07-15T10:21:56Z

<p><span dir="auto"><span class="autocomment">References</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 10:21, 15 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l46" >Line 46:</td> <td colspan="2" class="diff-lineno">Line 46:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4) https://www.ema.europa.eu/en/documents/product-information/accofil-epar-product-information_en.pdf</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4) https://www.ema.europa.eu/en/documents/product-information/accofil-epar-product-information_en.pdf</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Date of Last Update'''</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Date of Last Update'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>15/07/2025</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>15/07/2025</div></td></tr> <!-- diff cache key localdb-mw_:diff::1.12:old-2269:rev-2270 --> </table>

Frances.Sarkari@anthonynolan.org https://www.med-guidelines.org.uk/index.php?title=Hereditary_Fructose_Intolerance&diff=2269&oldid=prev 2025-07-15T10:21:45Z

<p><span dir="auto"><span class="autocomment">References</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 10:21, 15 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l46" >Line 46:</td> <td colspan="2" class="diff-lineno">Line 46:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4) https://www.ema.europa.eu/en/documents/product-information/accofil-epar-product-information_en.pdf</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4) https://www.ema.europa.eu/en/documents/product-information/accofil-epar-product-information_en.pdf</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''Date of Last Update'''</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">15/07/2025</ins></div></td></tr> <!-- diff cache key localdb-mw_:diff::1.12:old-2268:rev-2269 --> </table>

Frances.Sarkari@anthonynolan.org https://www.med-guidelines.org.uk/index.php?title=Hereditary_Fructose_Intolerance&diff=2268&oldid=prev 2025-07-15T10:20:21Z

<p><span dir="auto"><span class="autocomment">References</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 10:20, 15 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l45" >Line 45:</td> <td colspan="2" class="diff-lineno">Line 45:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3) https://medlineplus.gov/ency/article/000359.htm  </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3) https://medlineplus.gov/ency/article/000359.htm  </div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>4) <del class="diffchange diffchange-inline">Accofil, INN</del>-<del class="diffchange diffchange-inline">filgrastim</del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>4) <ins class="diffchange diffchange-inline">https://www.ema.europa.eu/en/documents/product</ins>-<ins class="diffchange diffchange-inline">information/accofil-epar-product-information_en.pdf</ins></div></td></tr> </table>

Frances.Sarkari@anthonynolan.org https://www.med-guidelines.org.uk/index.php?title=Hereditary_Fructose_Intolerance&diff=2267&oldid=prev 2025-07-15T10:19:44Z

<p><span dir="auto"><span class="autocomment">Guidance</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 10:19, 15 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l17" >Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>People with HFI must not be given Zarzio or Accofil (filgrastim) as they contain fructose/sorbitol (E420).  </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>People with HFI must not be given Zarzio or Accofil (filgrastim) as they contain fructose/sorbitol (E420).  </div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Not acceptable under any circumstances.</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Fructose is present in other medications. People with HFI often have other health-related complications due to the HFI.</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Not acceptable under any circumstances <ins class="diffchange diffchange-inline">for PBSC or BM donation</ins>.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pseudonyms or Related Conditions==</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pseudonyms or Related Conditions==</div></td></tr> <!-- diff cache key localdb-mw_:diff::1.12:old-2266:rev-2267 --> </table>

Frances.Sarkari@anthonynolan.org https://www.med-guidelines.org.uk/index.php?title=Hereditary_Fructose_Intolerance&diff=2266&oldid=prev 2025-07-15T10:18:01Z

<p>Created page with &quot;==Acceptability at Recruitment== UNACCEPTABLE ==Acceptability at VT / Work-Up== UNACCEPTABLE ==Individual at risk== Donor ==Explanation of Condition== Hereditary Fructose...&quot;</p> <p><b>New page</b></p><div>==Acceptability at Recruitment==<br /> UNACCEPTABLE<br /> <br /> ==Acceptability at VT / Work-Up==<br /> UNACCEPTABLE<br /> <br /> ==Individual at risk==<br /> Donor <br /> <br /> ==Explanation of Condition==<br /> Hereditary Fructose Intolerance (HFI) is a disorder in which a person lacks the protein needed to break down fructose. This condition occurs when the body is missing an enzyme called aldolase B. This substance is needed to break down fructose.<br /> If a person with HFI eats fructose or sucrose, complicated chemical changes occur in the body. The body cannot change its stored form of sugar (glycogen) into glucose. As a result, blood sugar falls and dangerous substances build up in the liver.<br /> HFI requires a lifelong avoidance of fructose, sucrose, and sorbitol. These sugars are commonly found in many foods and medications, and even small amounts can trigger severe reactions. HFI can lead to liver damage, kidney problems, and other health issues.<br /> Although HFI is not directly transmissible, the recipient of the bone marrow transplant will be immunocompromised and vulnerable to complications from the donor's dietary restrictions and potential underlying health issues.<br /> <br /> ==Guidance==<br /> People with HFI must not be given Zarzio or Accofil (filgrastim) as they contain fructose/sorbitol (E420). <br /> <br /> Not acceptable under any circumstances.<br /> <br /> ==Pseudonyms or Related Conditions==<br /> <br /> Fructosemia<br /> <br /> Fructose intolerance<br /> <br /> Fructose aldolase B-deficiency<br /> <br /> Fructose-1<br /> <br /> 6-bisphosphate aldolase deficiency<br /> <br /> HFI<br /> <br /> ==Version==<br /> Version 1, Edition 1<br /> <br /> ==References==<br /> 1) https://www.medicines.org.uk/emc/product/6672/smpc#PRECLINICAL_SAFETY <br /> <br /> 2) https://www.ema.europa.eu/en/documents/product-information/zarzio-epar-product-information_en.pdf <br /> <br /> 3) https://medlineplus.gov/ency/article/000359.htm <br /> <br /> 4) Accofil, INN-filgrastim</div>

Frances.Sarkari@anthonynolan.org