Inherited Blood Disorder, family history of - Revision history

82.45.134.242: /* Autosomal recessive */

2013-08-21T11:32:44Z

Autosomal recessive

2013-08-21T11:32:00Z

2013-08-21T11:31:15Z

Guidance

2013-08-21T11:27:42Z

Explanation of Condition

2013-08-21T11:26:21Z

Explanation of Condition

2013-08-21T11:20:54Z

Explanation of Condition

2013-08-21T11:19:40Z

Explanation of Condition

2013-08-21T11:15:12Z

Date of Last Update

2013-08-21T11:14:47Z

=At recruitment

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PAge created and updated

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 ====Autosomal recessive====
-May proceed at the discretion of the requesting transplant centre
+May join the register if clinically asymptomatic
 ===At CT/Work-up===

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 ====Autosomal recessive====
-May proceed at the discretion of the requesting transplant centreSee also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]
+May proceed at the discretion of the requesting transplant centre
 ==Version==

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 Refer all cases to the medical officer.
-Details of the inherited disease should be noted, as well as the underlying mutation, if known.
+Details of the inherited disease should be noted, including mode of inheritance as well as the underlying mutation, if known.
 ===At recruitment===
 May join the register only if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation.
 ===At CT/Work-up===
 May proceed if the potential donor has been tested for the causative mutation and found to not carry it, or if they have been told by a geneticist or haematologist that they do not carry the mutation. The transplant centre must be told of the family history, regardless of any genetic testing or counselling.
+====Autosomal recessive====
-See also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]
+May proceed at the discretion of the requesting transplant centreSee also specific guidance for [[Diamond-Blackfan Syndrome, family history of]]
 ==Version==

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 ==Explanation of Condition==
-Inherited disorders of blood production include such disorders as Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome. Please see separate guidance for [[Haemoglobin Disorder]]s and [[G6PD Deficiency]].
+Inherited disorders of blood production include such disorders as Diamond-Blackfan syndrome, Schwachman-Diamond syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome. Please see separate guidance for [[Haemoglobin Disorder]]s and [[G6PD Deficiency]].
 Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.

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 ==Explanation of Condition==
-Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.
+Inherited disorders of blood production include such disorders as Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome. Please see separate guidance for [[Haemoglobin Disorder]]s and [[G6PD Deficiency]].
 Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.

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 Inherited disorders of blood production include such disorders as [[Haemoglobin Disorder]]s, [[G6PD Deficiency]] Diamond-Blackfan syndrome, Blackfan-Schwachmann syndrome and congenital dyserythropoietic anaemia, as well as the inherited immune deficiencies such as Wiscott-Aldrich Syndrome.
-Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may cause clinical symptoms.
+Potential donors with a family history of an inherited blood disorder may carry the genetic abnormality that causes the syndrome, even though they do not show symptoms of the illness. This abnormality may be passed on to the recipient of transplant where it may limit engraftment or otherwise cause clinical symptoms.
 ==Guidance==