Pre-Malignant Conditions - Revision history

Ellouise.Bishop@anthonynolan.org: /* Guidance */

2025-08-26T14:22:30Z

Guidance

PaulM: /* Familial Adenomatous Polyposis */

2016-06-09T17:01:58Z

Familial Adenomatous Polyposis

PaulM: /* Cervical Intraepithelial Neoplasia (CIN) */

2016-06-09T17:01:24Z

Cervical Intraepithelial Neoplasia (CIN)

PaulM: /* BRCA1/BRCA2 Mutation */

2016-06-09T17:00:55Z

BRCA1/BRCA2 Mutation

PaulM: /* Guidance */

2016-06-01T16:18:59Z

Guidance

PaulM at 16:14, 1 June 2016

2016-06-01T16:14:48Z

PaulM: /* Familial Adenomatous Polyposis */

2016-06-01T16:10:19Z

Familial Adenomatous Polyposis

PaulM: /* BRCA1/BRCA2 Mutation */

2016-06-01T16:10:04Z

BRCA1/BRCA2 Mutation

PaulM: Created page with " ==Acceptability at Recruitment== NOT ACCEPTABLE ==Acceptability at CT / Work-Up== QUALIFIED, See below ==Individual at Risk== Recipient ==Explanation of Condition== Inher..."

2016-06-01T16:09:43Z

Created page with " ==Acceptability at Recruitment== NOT ACCEPTABLE ==Acceptability at CT / Work-Up== QUALIFIED, See below ==Individual at Risk== Recipient ==Explanation of Condition== Inher..."

New page

==Acceptability at Recruitment==
NOT ACCEPTABLE

==Acceptability at CT / Work-Up==
QUALIFIED, See below

==Individual at Risk==
Recipient

==Explanation of Condition==
Inherited conditions predisposing to risk of developing or transforming to malignancy

==Guidance==
Dependent on diagnosis, see below

===BRCA1/BRCA2 Mutation===

Not Acceptable at recruitment
Acceptable at VT. Inform TC

===Familial Adenomatous Polyposis===

Not Acceptable at recruitment
If undergoing regular screening programme and no features of malignant change discuss with TC at VT

==Version==
Version 1, Edition 1

====Date of Last Update====
1 June 2016

Women with known positivity for BRCA1 or 2 but no history of cancer are acceptable as donors. All such women should have a breast examination performed at work-up.

← Older revision		Revision as of 14:22, 26 August 2025
Line 31:		Line 31:

	VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC		VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC
		+
		+	===PALB2===
		+	Associated with a high risk of breast cancer and a moderately increased risk of ovarian, pancreatic and possibly other cancers)
		+
		+	Recruitment - Unacceptable
		+
		+	VT - Acceptable:
		+
		+	* If compliant with advised regular screening programme (e.g. for women very high risk breast cancer schedule) and no features/symptoms of malignant change – inform/consult MO
		+	*
		+	* All women should have a breast examination at medical
		+	*
		+	* Inform TC if under a screening/surveillance programme

	==Version==		==Version==

@@ Line 24: / Line 24: @@
 ===Cervical Intraepithelial Neoplasia (CIN)===
-Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.
+RECRUITMENT AND VT - Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.
 ===Familial Adenomatous Polyposis===

@@ Line 16: / Line 16: @@
 ===BRCA1/BRCA2 Mutation===
-Not Acceptable at recruitment
+RECRUITMENT - Not Acceptable
-Acceptable at VT if undergoing recommended screening. Inform TC at VT
+VT - Acceptable if undergoing recommended screening. Inform TC at VT
 All women should have a breast examination at medical
 ===Cervical Intraepithelial Neoplasia (CIN)===

← Older revision		Revision as of 16:18, 1 June 2016
Line 21:		Line 21:

	All women should have a breast examination at medical		All women should have a breast examination at medical
		+
		+
		+	===Cervical Intraepithelial Neoplasia (CIN)===
		+
		+	Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.
		+

	===Familial Adenomatous Polyposis===		===Familial Adenomatous Polyposis===

@@ Line 28: / Line 28: @@
 ===Familial Adenomatous Polyposis===
-Not Acceptable at recruitment
+RECRUITMENT - Not Acceptable
-If undergoing regular screening programme and no features of malignant change discuss with TC at VT
+VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC
 ==Version==

@@ Line 1: / Line 1: @@
- ==Acceptability at Recruitment==
+==Acceptability at Recruitment==
 NOT ACCEPTABLE
@@ Line 18: / Line 18: @@
 Not Acceptable at recruitment
-Acceptable at VT. Inform TC at VT
+Acceptable at VT if undergoing recommended screening. Inform TC at VT
 ===Familial Adenomatous Polyposis===
@@ Line 31: / Line 33: @@
 ====Date of Last Update====
 June 2016