https://www.med-guidelines.org.uk/index.php?action=history&feed=atom&title=Prion-Associated_DiseasePrion-Associated Disease - Revision history2026-05-04T20:07:06ZRevision history for this page on the wikiMediaWiki 1.34.1https://www.med-guidelines.org.uk/index.php?title=Prion-Associated_Disease&diff=891&oldid=prevDr Robert Lown: Protected "Prion-Associated Disease" ([edit=sysop] (indefinite) [move=sysop] (indefinite))2012-06-19T13:18:56Z<p>Protected "<a href="/Prion-Associated_Disease" title="Prion-Associated Disease">Prion-Associated Disease</a>" ([edit=sysop] (indefinite) [move=sysop] (indefinite))</p>
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</table>Dr Robert Lownhttps://www.med-guidelines.org.uk/index.php?title=Prion-Associated_Disease&diff=455&oldid=prevDr Robert Lown: Page created2012-06-14T12:51:34Z<p>Page created</p>
<p><b>New page</b></p><div>==Acceptability at Recruitment==<br />
NOT ACCEPTABLE<br />
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==Acceptability at CT / Work-Up==<br />
NOT ACCEPTABLE<br />
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==Individual at Risk==<br />
Recipient<br />
<br />
==Explanation of Condition==<br />
Prions are a newly identified type of infectious agent, which (unlike any other type of micro-organism) do not carry any DNA or RNA. They cause a group of diseases known as spongiform encephalopathies, which include scrapie in sheep, mad cow disease (BSE) in cows, and CJD in humans. <br />
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In the 1990s, a new form of CJD (variant CJD) was identified, and has since been proven to be a human form of BSE, contracted through eating infected beef products.<br />
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Variant CJD has not, to date, been transferred by stem cell donation, but a number of cases have been transmitted by blood transfusion. CJD can also be transferred through transplant of ocular (eye) or brain (dura mater) tissues, as well as hormones derived from pituitary tissue.<br />
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See also [http://en.wikipedia.org/wiki/Creutzfeldt-Jakob_disease Creutzfeldt-Jakob Disease]<br />
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==Guidance==<br />
Risk of transmission to recipient. <br />
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====Donor Affected====<br />
Unacceptable if suffered from a prion-associated disease<br />
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====Family History====<br />
Unacceptable if two or more blood relatives have, or have been told by a geneticist that they may be at risk of developing, a prion-associated disease. <br />
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Other family history should be discussed with the medical officer and transplant centre, and the opinion of a geneticist requested if necessary.<br />
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====Ocular tissue or dura mater graft recipient====<br />
Unacceptable if every received an ocular tissue or dura mater graft. Any other transplants should be discussed with the medical officer. <br />
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====Pituitary derived hormone therapy====<br />
Unacceptable if ever received hormones derived from human pituitary tissue. <br />
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==Pseudonyms or Related Conditions==<br />
Sporadic, familial and variant Creutzfeld-Jacob disease (CJD)<br />
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Gerstmann- Sträussler-Scheinker Disease<br />
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Fatal Familial Insomnia<br />
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Kuru<br />
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==Version==<br />
Version 1, Edition 1 <br />
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====Date of Last Update====<br />
15th June 2012</div>Dr Robert Lown