Pre-Malignant Conditions: Difference between revisions
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===BRCA1/BRCA2 Mutation=== | ===BRCA1/BRCA2 Mutation=== | ||
Not Acceptable | RECRUITMENT - Not Acceptable | ||
Acceptable | VT - Acceptable if undergoing recommended screening. Inform TC at VT | ||
All women should have a breast examination at medical | All women should have a breast examination at medical | ||
===Cervical Intraepithelial Neoplasia (CIN)=== | |||
RECRUITMENT AND VT - Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme. | |||
===Familial Adenomatous Polyposis=== | ===Familial Adenomatous Polyposis=== | ||
Not Acceptable at | RECRUITMENT - Not Acceptable | ||
VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC | |||
===PALB2=== | |||
Associated with a high risk of breast cancer and a moderately increased risk of ovarian, pancreatic and possibly other cancers) | |||
Recruitment - Unacceptable | |||
VT - Acceptable: | |||
* If compliant with advised regular screening programme (e.g. for women very high risk breast cancer schedule) and no features/symptoms of malignant change – inform/consult MO | |||
* | |||
* All women should have a breast examination at medical | |||
* | |||
* Inform TC if under a screening/surveillance programme | |||
===Uterine Hyperplasia=== | |||
RECRUITMENT - Unacceptable | |||
VT/WORKUP - Unacceptable if there are abnormal cells (aplasia) and the donor remains on monitoring. Consider if discharged from regular follow up on a case-by-case basis. | |||
==Version== | ==Version== | ||
Latest revision as of 14:19, 2 June 2026
Acceptability at Recruitment
NOT ACCEPTABLE
Acceptability at CT / Work-Up
QUALIFIED, See below
Individual at Risk
Recipient
Explanation of Condition
Inherited conditions predisposing to risk of developing or transforming to malignancy
Guidance
Dependent on diagnosis, see below
BRCA1/BRCA2 Mutation
RECRUITMENT - Not Acceptable
VT - Acceptable if undergoing recommended screening. Inform TC at VT
All women should have a breast examination at medical
Cervical Intraepithelial Neoplasia (CIN)
RECRUITMENT AND VT - Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.
Familial Adenomatous Polyposis
RECRUITMENT - Not Acceptable
VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC
PALB2
Associated with a high risk of breast cancer and a moderately increased risk of ovarian, pancreatic and possibly other cancers)
Recruitment - Unacceptable
VT - Acceptable:
- If compliant with advised regular screening programme (e.g. for women very high risk breast cancer schedule) and no features/symptoms of malignant change – inform/consult MO
- All women should have a breast examination at medical
- Inform TC if under a screening/surveillance programme
Uterine Hyperplasia
RECRUITMENT - Unacceptable
VT/WORKUP - Unacceptable if there are abnormal cells (aplasia) and the donor remains on monitoring. Consider if discharged from regular follow up on a case-by-case basis.
Version
Version 1, Edition 1
Date of Last Update
1 June 2016