Difference between revisions of "Pre-Malignant Conditions"

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(Created page with " ==Acceptability at Recruitment== NOT ACCEPTABLE ==Acceptability at CT / Work-Up== QUALIFIED, See below ==Individual at Risk== Recipient ==Explanation of Condition== Inher...")
 
 
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==Acceptability at Recruitment==
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==Acceptability at Recruitment==
 
NOT ACCEPTABLE
 
NOT ACCEPTABLE
  
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===BRCA1/BRCA2 Mutation===
 
===BRCA1/BRCA2 Mutation===
  
Not Acceptable at recruitment
+
RECRUITMENT - Not Acceptable  
Acceptable at VT. Inform TC
 
  
===Familial Adenomatous Polyposis===
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VT - Acceptable if undergoing recommended screening. Inform TC at VT
  
Not Acceptable at recruitment
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All women should have a breast examination at medical
If undergoing regular screening programme and no features of malignant change discuss with TC at VT
 
  
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===Cervical Intraepithelial Neoplasia (CIN)===
==Version==
 
Version 1, Edition 1
 
  
====Date of Last Update====
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RECRUITMENT AND VT - Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.
1 June 2016
 
  
 +
===Familial Adenomatous Polyposis===
  
 +
RECRUITMENT - Not Acceptable
  
 +
VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC
  
 +
===PALB2===
 +
Associated with a high risk of breast cancer and a moderately increased risk of ovarian, pancreatic and possibly other cancers)
  
 +
Recruitment - Unacceptable
  
 +
VT - Acceptable: 
  
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* If compliant with advised regular screening programme (e.g. for women very high risk breast cancer schedule) and no features/symptoms of malignant change – inform/consult MO 
 +
*
 +
* All women should have a breast examination at medical
 +
*
 +
* Inform TC if under a screening/surveillance programme
  
 +
==Version==
 +
Version 1, Edition 1
  
 
+
====Date of Last Update====
 
+
1 June 2016
 
 
 
 
 
 
 
 
 
 
 
 
Women with known positivity for BRCA1 or 2 but no history of cancer are acceptable as donors. All such women should have a breast examination performed at work-up.
 

Latest revision as of 14:22, 26 August 2025

Acceptability at Recruitment

NOT ACCEPTABLE

Acceptability at CT / Work-Up

QUALIFIED, See below

Individual at Risk

Recipient

Explanation of Condition

Inherited conditions predisposing to risk of developing or transforming to malignancy

Guidance

Dependent on diagnosis, see below

BRCA1/BRCA2 Mutation

RECRUITMENT - Not Acceptable

VT - Acceptable if undergoing recommended screening. Inform TC at VT

All women should have a breast examination at medical

Cervical Intraepithelial Neoplasia (CIN)

RECRUITMENT AND VT - Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.

Familial Adenomatous Polyposis

RECRUITMENT - Not Acceptable

VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC

PALB2

Associated with a high risk of breast cancer and a moderately increased risk of ovarian, pancreatic and possibly other cancers)

Recruitment - Unacceptable

VT - Acceptable:

  • If compliant with advised regular screening programme (e.g. for women very high risk breast cancer schedule) and no features/symptoms of malignant change – inform/consult MO
  • All women should have a breast examination at medical
  • Inform TC if under a screening/surveillance programme

Version

Version 1, Edition 1

Date of Last Update

1 June 2016