Difference between revisions of "Haemoglobin Disorder"
| Line 31: | Line 31: | ||
Sickle cell trait | Sickle cell trait | ||
| − | HbC, HbDPunjab/Oman, HbE traits | + | HbC, HbDPunjab/Oman, HbE traits or raised HbF% |
Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait. | Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait. | ||
There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only. | There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only. | ||
| + | |||
| + | Inform TC on clearance document. | ||
==Pseudonyms or Related Conditions== | ==Pseudonyms or Related Conditions== | ||
Latest revision as of 12:30, 2 June 2026
Contents
Acceptability at Recruitment
QUALIFIED
Acceptability at VT / Work-Up
QUALIFIED
Individual at Risk
Recipient
Explanation of Condition
Covers a wide variety of inhertied disorders of haemoglobin, of which the most common will be thalassaemia and sickle cell disease.
Guidance
Discuss with MO and inform transplant centre.
Unacceptable
Thalassaemia major or intermedia
Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD)
High affinity haemoglobin
Other clinically significant structural or functional haemoglobinopathies.
If mother or father homozygous or heterozygous for inherited haemoglobin disorders and infant affected
Acceptable if haemoglobin is within normal sex-adjusted range
Alpha or beta thalassaemia trait
Sickle cell trait
HbC, HbDPunjab/Oman, HbE traits or raised HbF%
Other asymptomatic traits or compound haemoglobinopathies e.g. HbC/a-thal trait.
There is no evidence of clinically significant sickling during PBSC in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC, so those with sickle cell trait must donate by BM only.
Inform TC on clearance document.
Pseudonyms or Related Conditions
Version
Version 1, Edition 2
Date of Last Update
1 June 2016
