Asthma

Acceptability at Recruitment

ACCEPT if condition is controlled with (daily) inhalers or non-steroidal oral medication (e.g. Monteleukast)

DEFER if condition requires oral steroids or steroid sparing agents (e.g. Omalizumab)

Acceptability at CT / Work-Up

PBSC

ACCEPT if condition is controlled with (daily) inhalers or non-steroidal oral medication (e.g. monteleukast)

DEFER if condition is poorly controlled and/or requires oral steroids or steroid sparing agents (e.g. Omalizumab)

BM

MAY BE ACCEPTABLE if condition is controlled with (daily) inhalers or non-steroidal oral medication. However, all cases should be discussed with an anaesthetist at the time of work-up.

DEFER if condition is severe and/or requires oral steroids or steroid sparing agents

All donors If a donor is unsuitable for bone marrow harvest, the requesting transplant centre must be informed that there will not be an option of rescue marrow harvest in the case of failed mobilization.

Individual at Risk

Donor

Explanation of Condition

Constriction of the airways which may be triggered by external stimuli (such as cold air, pollen or pollution) or may be spontaneous. Usually controlled by a combination of bronchodilator inhalers (such as salbutamol) and steroid inhalers (such as beclometasone). More severe asthma may require tablet therapy such as theophylline, montelukast or steroids.

Asthmatics are at a higher risk from donation, and from general anaesthetic in particular.

Guidance

Mild asthma is acceptable. However, the condition must be reassessed and evaluated in case of a HR/CT or work up request. The risk for exacerbation is increased if the condition is severe.

Pseudonyms or Related Conditions

Bronchospasm

Version

Version 1, Edition 1

Date of Last Update

15th June 2012