Pre-Malignant Conditions

Acceptability at Recruitment

NOT ACCEPTABLE

Acceptability at CT / Work-Up

QUALIFIED, See below

Individual at Risk

Recipient

Explanation of Condition

Inherited conditions predisposing to risk of developing or transforming to malignancy

Guidance

Dependent on diagnosis, see below

BRCA1/BRCA2 Mutation

RECRUITMENT - Not Acceptable

VT - Acceptable if undergoing recommended screening. Inform TC at VT

All women should have a breast examination at medical

Cervical Intraepithelial Neoplasia (CIN)

RECRUITMENT AND VT - Acceptable at recruitment and VT if spontaneous resolution, or removed surgically or with cryo/laser therapy, with histologically confirmed Cervical Intra-epithelial Neoplasia (CIN) 1,2 or 3, and donor back on routine national screening programme.

Familial Adenomatous Polyposis

RECRUITMENT - Not Acceptable

VT - If undergoing regular screening programme and no features of malignant change may be acceptable. Discuss with MO and TC

PALB2

Associated with a high risk of breast cancer and a moderately increased risk of ovarian, pancreatic and possibly other cancers)

Recruitment - Unacceptable

VT - Acceptable:

• If compliant with advised regular screening programme (e.g. for women very high risk breast cancer schedule) and no features/symptoms of malignant change – inform/consult MO
• All women should have a breast examination at medical
• Inform TC if under a screening/surveillance programme

Version

Version 1, Edition 1

Date of Last Update

1 June 2016