PrEP
PrEP – Pre-Exposure Prophylaxis
Contents
Acceptability at Recruitment
Acceptable BUT inform donors that they should be off PrEP for 3 months to proceed at VT
Acceptability at CT / Work-Up
Acceptable if donor has been off PrEP for at least 3 months + low sexual risk behaviour.
Otherwise postpone.
Individual at Risk
Recipient
Explanation of Condition
Pre-Exposure Prophylaxis (PrEP) is a course of HIV drugs (Truvada= tenofovir + emtricitabine) taken by HIV negative people who are at high risk of infection with HIV. It lowers the risk of becoming HIV positive. It can be taken either regularly or “on-demand” (before and after sexual encounters).
Justification for guidance
Similar to High Risk Sexual Behaviour: With use of modern screening techniques, the risk of unintended transmission of an infectious disease is very small. Stem cell donors undergo in-depth medical and sexual health questionnaires, and will have a face-to-face interview with donor centre staff, allowing ample opportunity to identify those donors at increased risk of contracting a window-period infection.
In many cases, the benefit to the recipient of receiving a donation will vastly outweigh the risk of transmission of an infectious agent. Therefore, this time period me be reduced at the discretion of the requesting transplant centre.