Proteinuria

Acceptability at Recruitment

ACCEPTABLE

Acceptability at VT / Work-Up

ACCEPTABLE

Individual at risk

Donor

Explanation of Condition

Protein present in urine, found either from a urine dipstick test or a Microbiology, Culture & Sensitive (MC&S) test.

Guidance

If isolated proteinuria is detected, a urine albumin-to-creatinine ratio (ACR) test must be conducted. Proteinuria can be a sign of underlying kidney conditions such as IgA nephropathy or glomerulonephritis, both of which are often undiagnosed. Administration of granulocyte colony-stimulating factor (G-CSF) may worsen these conditions, which is the basis for this precaution.

To be medically cleared for donation, the donor must have a negative urine protein test, or the ACR is <5 mg/mmol ensuring that kidney disease is unlikely. If proteinuria is present, the algorithm on the following link must be followed:

https://www.med-guidelines.org.uk/images/c/ca/Urine_algorithm.jpg

For haematuria, please see haematuria

If both blood and protein are present in the urine, both urine ACR and a MC&S/ MSU must be tested.

Pseudonyms or Related Conditions

IgA Nephropathy

Berger’s disease

Glomerulonephritis

Version 1, Edition 1

Date of Last Update

14/07/2025