Difference between revisions of "Proteinuria"

From Anthony Nolan Medical Guidelines
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==Guidance==
 
==Guidance==
If protein is present in the urine, a urine albumin to creatinine ratio (ACR) test must be performed. Protein is found in people with a kidney disease called Ig Nephropathy, which is frequently undiagnosed as well as Glomerulonephritis. G-CSF can exacerbate this condition, hence the rationale.  
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The donor must have a protein negative urine test to be medically cleared for donation to rule out the possibility of Ig Nephropathy and Glomerulonephritis. If the donor has proteinuria, the following algorithm must be followed:
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If protein is detected in the urine, a urine albumin-to-creatinine ratio (ACR) test must be conducted. Proteinuria can be a sign of underlying kidney conditions such as IgA nephropathy or glomerulonephritis, both of which are often undiagnosed. Administration of granulocyte colony-stimulating factor (G-CSF) may worsen these conditions, which is the basis for this precaution.
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To be medically cleared for donation, the donor must have a negative urine protein test, ensuring that these kidney diseases are unlikely. If proteinuria is present, the following clinical algorithm must be followed:
  
 
For haematuria, please see [[haematuria]]
 
For haematuria, please see [[haematuria]]

Revision as of 09:42, 15 July 2025


Acceptability at Recruitment

ACCEPTABLE

Acceptability at VT / Work-Up

ACCEPTABLE

Individual at risk

Donor

Explanation of Condition

Protein present in urine, found either from a urine dipstick test or a Microbiology, Culture & Sensitive (MC&S) test.

Guidance

If protein is detected in the urine, a urine albumin-to-creatinine ratio (ACR) test must be conducted. Proteinuria can be a sign of underlying kidney conditions such as IgA nephropathy or glomerulonephritis, both of which are often undiagnosed. Administration of granulocyte colony-stimulating factor (G-CSF) may worsen these conditions, which is the basis for this precaution.

To be medically cleared for donation, the donor must have a negative urine protein test, ensuring that these kidney diseases are unlikely. If proteinuria is present, the following clinical algorithm must be followed:

For haematuria, please see haematuria

Pseudonyms or Related Conditions

IgA Nephropathy

Berger’s disease

Glomerulonephritis

Version 1, Edition 1

Date of Last Update

14/07/2025