Difference between revisions of "Proteinuria"

From Anthony Nolan Medical Guidelines
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==Guidance==
 
==Guidance==
  
If protein is detected in the urine, a urine albumin-to-creatinine ratio (ACR) test must be conducted. Proteinuria can be a sign of underlying kidney conditions such as IgA nephropathy or glomerulonephritis, both of which are often undiagnosed. Administration of granulocyte colony-stimulating factor (G-CSF) may worsen these conditions, which is the basis for this precaution.
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If isolated proteinuria is detected, a urine albumin-to-creatinine ratio (ACR) test must be conducted. Proteinuria can be a sign of underlying kidney conditions such as IgA nephropathy or glomerulonephritis, both of which are often undiagnosed. Administration of granulocyte colony-stimulating factor (G-CSF) may worsen these conditions, which is the basis for this precaution.
  
 
To be medically cleared for donation, the donor must have a negative urine protein test, or the ACR is <5 mg/mmol ensuring that kidney disease is unlikely. If proteinuria is present, the algorithm on the following link must be followed:
 
To be medically cleared for donation, the donor must have a negative urine protein test, or the ACR is <5 mg/mmol ensuring that kidney disease is unlikely. If proteinuria is present, the algorithm on the following link must be followed:
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For haematuria, please see [[haematuria]]
 
For haematuria, please see [[haematuria]]
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If both blood and protein are present in the urine, both urine ACR and a MC&S/ MSU must be tested.
  
 
==Pseudonyms or Related Conditions==
 
==Pseudonyms or Related Conditions==

Latest revision as of 12:15, 16 July 2025


Acceptability at Recruitment

ACCEPTABLE

Acceptability at VT / Work-Up

ACCEPTABLE

Individual at risk

Donor

Explanation of Condition

Protein present in urine, found either from a urine dipstick test or a Microbiology, Culture & Sensitive (MC&S) test.

Guidance

If isolated proteinuria is detected, a urine albumin-to-creatinine ratio (ACR) test must be conducted. Proteinuria can be a sign of underlying kidney conditions such as IgA nephropathy or glomerulonephritis, both of which are often undiagnosed. Administration of granulocyte colony-stimulating factor (G-CSF) may worsen these conditions, which is the basis for this precaution.

To be medically cleared for donation, the donor must have a negative urine protein test, or the ACR is <5 mg/mmol ensuring that kidney disease is unlikely. If proteinuria is present, the algorithm on the following link must be followed:

https://www.med-guidelines.org.uk/images/c/ca/Urine_algorithm.jpg

For haematuria, please see haematuria

If both blood and protein are present in the urine, both urine ACR and a MC&S/ MSU must be tested.

Pseudonyms or Related Conditions

IgA Nephropathy

Berger’s disease

Glomerulonephritis

Version 1, Edition 1

Date of Last Update

14/07/2025