Bleeding Disorder

Acceptability at Recruitment

QUALIFIED

Acceptability at CT / Work-Up

QUALIFIED

Individual at Risk

Donor

Explanation of Condition

Most haemophilias are inherited disorders of blood clotting. They may be of varying severity, but generally prohibit bone marrow donation.

Some haemophilias are acquired during life, and may be transient.

Guidance

Discuss with medical officer.

For known history:

Unacceptable if history of excessive spontaneous or provoked bleeding, or laboratory demonstrated severe or moderate haemophilia (including asymptomatic factor XI deficiency).

Female carriers of haemophilia A and B should be discussed with medical officer. Consider for PBSC only if bleeding risk thought to be negligeable and after liaison with haemophilia centre.

Not for central venous catheter insertion or bone marrow harvest.

Any degree of factor XII deficiency is acceptable as long as there is no history of thrombosis.

For newly identified clotting abnormalities at medical:

Assess the donor for personal and family history of excessive bleeding and bruising.

• Has the donor noticed any excessive bleeding – e.g. after injuries or cuts?

• Does the donor experience heavy periods?

• Have there been any issues with bleeding that was difficult to stop following an operation or tooth extraction?

• Does the donor experience nosebleeds? If so, how often do they happen, are the nosebleeds from one nostril or both, how long do they take to stop and what measures are needed for the nosebleeds to stop?

• Has the donor ever experienced significant joint swelling? (i.e. potentially bleeding into their joints).

• Has the donor noticed any easy bruising?

• Has the donor had any blood clots in the past?

• Are there any family members with bleeding disorders, or abnormal bleeding or bruising?

• Are there any family members who have had blood clots?

If the history is reassuring, repeat the coagulation screen with relevant factor levels as spurious results can occur.

If APTT remains prolonged in isolation but factor levels are normal and there is no bleeding history - the donor can be cleared if the CC are in agreement. If there are concerns from the CC or regarding bleeding history discuss case with a clotting specialist.

Pseudonyms or Related Conditions

Haemophilia A

Haemophilia B

Factor XIII, XI, VIII, VII or V Deficiency

Hypofibrinogenaemia

Dysfibrinogenaemia

Von Willebrand Disease

Platelet Function Defect

Platelet Disorder

Version

Version 1, Edition 1

Date of Last Update

15th June 2012