Bleeding Disorder

Acceptability at Recruitment

QUALIFIED

Acceptability at VT / Work-Up

QUALIFIED

Individual at Risk

Donor

Explanation of Condition

Most haemophilias are inherited disorders of blood clotting. They may be of varying severity, but generally prohibit bone marrow donation.

Some haemophilias are acquired during life, and may be transient.

Guidance

Discuss with medical officer.

For known history:

Unacceptable if history of excessive spontaneous or provoked bleeding, or laboratory demonstrated severe or moderate haemophilia (including asymptomatic factor XI deficiency).

Female carriers of haemophilia A and B should be discussed with medical officer. Consider for PBSC only if bleeding risk thought to be negligeable and after liaison with haemophilia centre.

Not for central venous catheter insertion or bone marrow harvest.

Any degree of factor XII deficiency is acceptable as long as there is no history of thrombosis.

For newly identified clotting abnormalities at medical:

Assess the donor for personal and family history of excessive bleeding and bruising.

• Has the donor ever experienced excessive bleeding, such as prolonged bleeding after cuts or injuries?
• Does the donor have heavy menstrual periods?
• Has the donor ever had difficulty stopping bleeding after surgery or a dental procedure?
• Does the donor experience nosebleeds? If so, how frequently do they occur, do they affect one or both nostrils, how long do they last, and what measures are needed to stop them?
• Has the donor ever had sudden or significant joint swelling that could indicate bleeding into the joints?
• Does the donor bruise easily?
• Is there a family history of bleeding disorders, unusual bleeding, or easy bruising?

If the history is reassuring, repeat the coagulation screen with relevant factor levels as spurious results can occur.

If APTT remains prolonged in isolation but factor levels are normal and there is no bleeding history - the donor can be cleared if the CC are in agreement. If there are concerns from the CC or regarding bleeding history discuss case with a clotting specialist.

Pseudonyms or Related Conditions

Haemophilia A

Haemophilia B

Factor XIII, XI, VIII, VII or V Deficiency

Hypofibrinogenaemia

Dysfibrinogenaemia

Von Willebrand Disease

Platelet Function Defect

Platelet Disorder

Version

Version 1, Edition 1

Date of Last Update

15th June 2012