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Revision as of 17:19, 9 June 2016
Contents
- 1 About the Anthony Nolan Medical and Lifestyle Guidelines
- 2 Guidance for Recruiters
- 3 Recently Updated Guidance
- 4 Multiple Medical Conditions
- 5 Index of Conditions
- 6 Appendix 1 - Haematologic and biochemical testing at donor medical
- 7 Appendix 2 - Infectious disease marker testing at ET/CT and donor medical
- 8 Appendix 3 - Other investigations at donor medical
- 9 Appendix 4 - Special consideration for donors in the Armed Forces
About the Anthony Nolan Medical and Lifestyle Guidelines
For potential and current donors, please note that these guidelines are primarily intended for use by Anthony Nolan staff.
The Anthony Nolan Medical and Lifestyle Guidelines are put in place to ensure the safety of both our stem cell donors and the recipients of their donations.
Because of the volunteer nature of stem cell donation, we have a responsibility to ensure that our donors are able to donate safely, with minimal risk to their own health. For this reason, our medical criteria are strict, and considerably more strict than medical criteria for having a procedure, such as an operation, for the benefit of your own health.
Some donor medical conditions present a risk to the recipient of the donation. In these cases, we may allow a donor to donate because the benefit for the patient of receiving the transplant outweighs the risk.
Guidance for Recruiters
The list is not exhaustive; therefore, particular cases may require further clarification by our Medical Officer.
IN SUCH CASES PLEASE NOTE THE FOLLOWING: The volunteer should be asked to complete an application form giving full details of their medical status ensuring that the following information is given:
- Name of medical condition.
- Date of diagnosis.
- Name of medication(s) taken.
- Length of time medication has been taken.
- Is the medication seen as a short course or long-term prescription?
- Does the volunteer have any limitations to life-style?
- Is the volunteer’s condition regularly assessed by GP/Consultant?
Once the application has been reviewed the donor will be contacted and informed of the decision.
This list is in place to help us recruit medically eligible volunteer blood stem cell donors. We have a duty to ensure that volunteer donors are put at minimal risk whilst also considering the safety and outcome for transplant recipients.
The criteria, which we use to assess the suitability of a volunteer to donate, are considerably more stringent than those taken into consideration for volunteers undergoing a procedure for their own medical health status.
If you have any queries please contact The Anthony Nolan Donor Support Team
as follows:
Telephone 0303 303 0303 (9am – 5pm) and ask for The Donor Support Team or E-mail: info@anthonynolan.org
Recently Updated Guidance
Review of all guidelines June 2016
Multiple Medical Conditions
Some donors will have more than one medical problem, and the potential combinations are too numerous to list in this guidance. Some combinations of conditions will increase the risk of donor harm, despite being acceptable in isolation.
For example, hypertension, smoking, high cholesterol and diet-controlled diabetes may all be acceptable, but this combination in an older donor would considerably increase their risk of a heart attack or stroke.
If in doubt, please discuss these donors with the medical officer.
Index of Conditions
A
Accident, See Fracture and/or Surgery
Acetylcholinesterase Deficiency
Acitretin, See Acne
Acoustic Schwannoma, See Acoustic Neuroma
ADD, See Attention Deficit Hyperactivity Disorder
Adenocarcinoma, See Malignancy
ADHD, See Attention Deficit Hyperactivity Disorder
Adrenal Hyperplasia, See Congenital Adrenal Hyperplasia
AIDS, See HIV
Alpha 1 Antitrypsin Deficiency
Alpha Mannosidosis, See Inherited Disease
Anabolic Steroids, See Addiction and Drug Abuse
Angina, See Heart, Coronary Artery Disease
Anthrax Vaccine, See Immunisation
Anti-Inflammatory Drug, See Non Steroidal Anti-Inflammatory Drug
Anticonvulsants, See Epilepsy
Antithrombin Deficiency, See Thrombophilia
Aortic Regurgitation, See Heart, Valve Disease
Aortic Stenosis, See Heart, Valve Disease
Aortic Valve Disease, See Heart, Valve Disease
Arrhythmia, See Heart, Arrhythmia
Arthroscopy, See Surgery
Aspirin, See Non Steroidal Anti-Inflammatory Drug
Atherosclerosis, See Heart, Coronary Artery Disease
Atrial Fibrillation, See Heart, Arrhythmia
Atrial Myxoma, See Myxoma
Atrial Septal Defect (ASD), See Heart, Congenital Defect
Attention Deficit Hyperactivity Disorder
Avodart, See Dutasteride
Avulsion Fracture (Other Than Spinal), See Fracture
Avulsion Fracture (Spinal), See Back Conditions
B
Balanitis Xerotica Obliterans (BXO)
BCG Vaccination, See Immunisation
Benign Essential Tremor, See Essential Tremor
Benign Ethnic Neutropenia, See Neutropenia
Benign Intracranial Hypertension, See Idiopathic Intracranial Hypertension
Berger Disease, See Kidney Disease
Beta Blockers, See Medications
Beta Thalassemia, See Haemoglobin Disorder
Bilateral Scleritis, See Eye Disease
Bilharzia, See Schistosomiasis
Bisexual, See Sexual Orientation
Blocked Artery (Heart), See Heart, Coronary Artery Disease
Blood Clot, See Thrombosis
Blood Pressure, See Hypertension
Blood Transfusion, See Transfusion
Bone Density (Abnormal), See Osteoporosis
Bone Graft, See Surgery and/or Back Conditions
Borreliosis, See Lyme Disease
Bowens Disease, See Malignancy
BPH, See Benign Prostatic Hyperplasia
Brain Surgery, See Neurosurgery
BRCA Mutation, See Pre-Malignant Conditions
Breast Augmentation (Implants)
Bronchitis, See Infection, Acute
Brown-Sequard Syndrome, See Central Nervous System Disease
C
C1 Esterase Inhibitor Deficiency
Cancer, See Malignancy
Candidiasis, See Candida Infection
Carcinoid Syndrome, See Malignancy
Cardiac Failure, See Heart, Muscle Disease
Cardiac Syndrome X, See Heart, Coronary Artery Disease
Cardiomegaly, See Heart, Muscle Disease
Cardiomyopathy, See Heart, Muscle Disease
Cat-Scratch Fever, See Infection, Acute
Cellulitis, See Infection, Acute
Central Nervous System Disease
Cerebral Malaria, See Malaria
Cervical Intraepithelial Neoplasia (CIN), See Pre-Malignant Conditions
Cervical Spondylosis, See Back Conditions
Chagas Disease, See South American Trypanosomiasis
Charcot Marie Tooth Syndrome, See Hereditary Motor Sensory Neuropathy
Chlamydia, See Infection, Acute
Cholecystectomy, See Surgery
Cholecystitis, See Gall-Bladder Disease
Christmas Disease, See Bleeding Disorder
Chronic Fatigue Syndrome, See Myalgic Encephalomyelitis
Chronic Obstructive Pulmonary Disease
CJD, See Prion-Associated Disease
Clap, See Gonorrhoea
Coagulation Disorder, See Bleeding Disorder or Thrombophilia
Coccydynia, See Back Conditions
Coldsore, See Herpes Simplex Virus
Cone Biopsy, See Cervical Carcinoma In-Situ
Congenital Adrenal Hyperplasia
Congenital Dwarfism, See Achondroplasia
Conn Syndrome, See Hyperaldosteronism
COPD, See Chronic Obstructive Pulmonary Disease
Coronary Artery Disease, See Heart, Coronary Artery Disease
Coronary Thrombosis, See Heart, Coronary Artery Disease
Coxsackie Virus, See Infection, Acute
Creutzfeld-Jacob Disease, See Prion-Associated Disease
Crimean Fever, See Brucellosis
Crimean-Congo Haemorrhagic Fever, See Congo Fever
Crohns Disease, See Inflammatory Bowel Disease
Crush Fracture (Spinal), See Back Conditions
Cutaneous Leishmaniasis, See Leishmaniasis
D
Deep Vein Thrombosis, See Thrombosis
Dengue Fever, See Infection, Acute
Diamond-Blackfan Syndrome, see Inherited Disease
Diclofenac, See Non Steroidal Anti-Inflammatory Drug
Disc (Removal/Micro Discectomy), See Back Conditions
Disc Protrusion/Prolapse, See Back Conditions
Discoid Lupus, See Systemic Lupus Erythematosus
Double-Jointed, See Hypermobility Syndrome
Drug Abuse, See Injection of Non-Prescription drugs
Drug Treatment, See Medications
Drug Trial, See Clinical Trial
Dwarfism, See Achondroplasia
Dysentery, See Infection, Acute
Dysfibrinogenaemia, See Bleeding Disorder
Dyspepsia, See Gastro-Oesophageal Reflux
Dystonia, See Central Nervous System Disease
E
Ebola Fever,See Viral Haemorrhagic Fever
EBV, See Epstein-Barr Virus
Eclampsia, See Pre-Eclampsia
Elephantiasis, See Filariasis
Emphysema, See Chronic Obstructive Pulmonary Disease
Episcleritis, See Eye Disease
ERPC (Evacuation Of Retained Products Of Conception), See Surgery
Essential Thrombocythemia, See Myeloproliferative Neoplasm
F
Factor 5 Leiden, See Thrombophilia
Factor 5 (V), 7 (VII), 8 (VIII), 9 (IX), 11 (XI) Deficiency, See Bleeding Disorder
Factor V Leiden, See Thrombophilia
Familial Hypercholesterolaemia, See Hyperlipidaemia
Familial Adenomatous Polyposis, See Pre-Malignant Conditions
Felty Syndrome, See Rheumatoid Arthritis
Fertility Treatment, See Hormone Replacement Therapy
Fibrosarcoma, See Malignancy
Flu, See Influenza
G
Gallstones, See Gall-Bladder Disease
Gammopathy, See Malignancy
Gender Reassignment See Transgender
Genetic Traits, See Inherited Disease
Genital Herpes, See Herpes Simplex Virus
Gilles De La Tourette Syndrome
Glandular Fever, See Epstein-Barr Virus
Glaucoma, See Eye Disease
Gluten Intolerance, See Coeliac Disease
Goitre (Enlarged Thyroid), See Thyroid Disease
Graves Disease, See Thyroid Disease
Growth Hormone Therapy, See Hormone Replacement Therapy
Guttate Psoriasis, See Psoriasis
H
H. Pylori, See Helicobacter Pylori
Haemoglobin C, See Haemoglobin Disorder
Haemoglobin Camden, See Haemoglobin Disorder
Haemoglobin D, See Haemoglobin Disorder
Haemoglobin E, See Haemoglobin Disorder
Haemoglobin Level, See Anaemia
Haemoglobin S, , See Haemoglobin Disorder
Haemophilia, See Bleeding Disorder
Haemophilia Carrier, See Bleeding Disorder
Hashimotos Thyroiditis, See Thyroid Disease
Heart Attack, See Heart, Coronary Artery Disease
Heart Block, See Heart, Arrhythmia
Heart Murmur, See Heart, Valve Disease
Heart, Coronary Artery Disease
Heavy Periods, See Menorrhagia
Henoch-Schonlein Purpura, See Vasculitis
Hereditary Haemorrhagic Telangiectasia
Hereditary Motor Sensory Neuropathy
Hereditary Polyposis, See Familial Polyposis
Hereditary Spastic Paraplegia, See Central Nervous System Disease
Herpes Zoster Virus, See Chicken Pox
High Affinity Haemoglobin, See Haemoglobin Disorder
High Cholesterol, See Hyperlipidaemia
Hodgkin Lymphoma, See Malignancy
HRT, See Hormone Replacement Therapy
Hughes Syndrome, See Anti-Phospholipid Syndrome
Human Bite, See Innoculation Injury
Human Growth Hormone], See Hormone Replacement Therapy
Human Immunodeficiency Virus, See HIV
Hydatidiform Mole, See Pregnancy
Hypercholesterolaemia, See Hyperlipidaemia
Hyperprolactinaemia, See Pituitary Adenoma
Hyperthyroidism, See Thyroid Disease
Hypertrophic Obstructive Cardiomyopathy
Hypoadrenalism, See Addison Disease
Hypofibrinogenaemia, See Bleeding Disorder
Hypothyroidism, See Thyroid Disease
Hysterectomy, See Surgery
I
Ibuprofen, See Non Steroidal Anti-Inflammatory Drug
Idiopathic Intracranial Hypertension
IgA Nephropathy, See Kidney Disease
Immune Deficiency, See Immunosuppression
Immunoglobulin Therapy, See Transfusion
In-vitro Fertilisation, Seee Hormone Replacement Therapy
Infectious Mononucleosis, See Epstein-Barr Virus
Infective Endocarditis, See Endocarditis
Influenza Vaccination, See Immunisation
Inherited Blood Disorder, first degree relative with
Injection of Non-Prescription drugs
Intermittent Claudication, See Peripheral Vascular Disease
Ischaemic Heart Disease, See Heart, Coronary Artery Disease
IVF, See Hormone Replacement Therapy
J
K
Kala-Azar, See Leishmaniasis
Key-Hole Surgery, See Surgery
Kidney Transplant, See Tissue Or Organ Transplant
Kienbock Disease, See Avascular Necrosis
Kyphosis, See Back Conditions
L
Laminectomy, See Back Conditions
Laparoscopy, See Surgery
Latex Allergy, See Allergy
Left Branch Bundle Block, See Heart, Arrhythmia
Legionnaire's Disease, See Infection, Acute
Leptospirosis See Infection, Acute
Leukaemia, See Malignancy
Low Blood Pressure, See Hypotension
Low Haemoglobin, See Anaemia
Low Platelets, See Thrombocytopenia
Lumbar Spine Abnormality, See Back Conditions
Lupus, See Systemic Lupus Erythematosus
Lyme Disease, See Infection, Acute
M
Malignant Melanoma, See Malignancy
Manic Depression, See Bipolar Affective Disorder
Marburg Fever, See Viral Haemorrhagic Fever
Mastectomy, See Surgery
Mastoid Operation, See Surgery
ME, See Myalgic Encephalomyelitis
Medical Trial, See Clinical Trial
Membranous Glomerulonephritis, See Kidney Disease
Meningioma, See Brain Tumour
Meningitis, See Infection, Acute
Metabolic Disease, Seee Inherited Disease
MGUS, See Monoclonal Gammopathy
Micropituitary Adenoma, See Pituitary Adenoma
Mitral Regurgitation, See Heart, Valve Disease
Mitral Stenosis, See Heart, Valve Disease
Mitral Valve Disease, See Heart, Valve Disease
Mononucleosis, See Epstein-Barr Virus
Motor Neurone Disease, See Central Nervous System Disease
Motor Sensory Neuropathy, See Hereditary Motor Sensory Neuropathy
MS, See Multiple Sclerosis
Myelofibrosis, See Myeloproliferative Neoplasm
Myoclonus, See Central Nervous System Disease
Myotonia Congenita, See Muscular Dystrophy
Myotonic Dystrophy, See Muscular Dystrophy
Myxoedema, See Thyroid Disease
N
Needlestick Injury, See Innoculation Injury
Neotigason, See Acne
Nephrectomy (Kidney Removal), See Kidney, Single
Nephritis, See Kidney Disease
Nephropathy, See Kidney Disease
Nephrotic Syndrome, See Kidney Disease
Neuroma, See Brain Tumour
Non Steroidal Anti-Inflammatory Drug
Non-Hodgkin Lymphoma, See Malignancy
Nose Bleed, See Epistaxis
NSAID, See Non Steroidal Anti-Inflammatory Drug
O
Obesity, See Weight
Oesophagitis, See Gastro-Oesophageal Reflux
Operation, See Surgery
Osler-Weber-Rendu Disease, See Hereditary Haemorrhagic Telangiectasia
Osteodystrophia Deformans, See Paget Disease
Osteoma, See Osteochondroma
P
Pacemaker, See Heart, Arrhythmia
Paget Disease Of The Nipple, See Malignancy
Panic Attacks, See Anxiety Disorder
Paraplegia, See Disabled Volunteer
Paraprotein, See Monoclonal Gammopathy
Parkinson Disease, See Central Nervous System Disease
Patent Ductus Arteriosus, See Heart, Congenital Defect
Patent Foramen Ovale, See Heart, Congenital Defect
Peroneal Muscular Atrophy, See Hereditary Motor Sensory Neuropathy
Phaeochromocytoma, See Malignancy
Pneumonia, See Infection, Acute
Polio, See Disabled Volunteer
Polyarteritis Nodosa, See Vasculitis
Polycythemia Rubra Vera, See Myeloproliferative Neoplasm
Positive Cervical Smear, See Cervical Carcinoma In-Situ
Post-Viral Fatigue Syndrome, See Myalgic Encephalomyelitis
POTS (Postural Orthostatic Tachycardia Syndrome)
Prolactinoma, See Pituitary Adenoma
Prolapsed Disc, See Back Conditions
Prostatism, See Benign Prostatic Hyperplasia
Protein C Deficiency, See Thrombophilia
Protein S Deficiency, See Thrombophilia
Prothrombin Gene Mutation, See Thrombophilia
Psoriatic Arthritis, See Psoriasis
Pulmonary Embolus, See Thrombosis
Pulmonary Stenosis / Regurgitation, See Heart, Congenital Defect
Pulmonary Valvotomy, See Heart, Valve Disease
Pyelonephritis, See Kidney Disease
Q
R
Reflux, See Gastro-Oesophageal Reflux
Reiter Syndrome, See Reactive Arthritis
Renal Colic, See Kidney Disease
Renal Disease, See Kidney Disease
Ricketts, See Disabled Volunteer
Right Bundle Branch Block, See Heart, Arrhythmia
River Blindness, See Onchocerciasis
Roaccutane, See Acne
Rocky Mountain Spotted Fever, See Rickettsial Infection
Rodent Ulcer, See Basal Cell Carcinoma
S
Sacroiliac Joint Problems, See Back Conditions
Sandhoff Disease, See Inherited Disease
Scheuermann Disease, See Back Conditions
Schwannoma, See Acoustic Neuroma
Sciatica, See Back Conditions
Scoliosis, See Back Conditions
Seizures, See Epilepsy
Sex Change, See Gender Reassignment
Shingles, See Chicken Pox
Shwachman-Diamond Syndrome, See Inherited Disease
Sleeping Sickness, See African Trypanosomiasis
Smear - Abnormal Cervical, See Cervical Carcinoma In-Situ
South American Trypanosomiasis
Spasmodic Torticollis, See Back Conditions
Spherocytosis, See Hereditary Spherocytosis
Spinal Fusion, See Back Conditions
Spinal Muscular Atrophy, See Inherited Disease
Spinal Stenosis, See Back Conditions
Spondylolisthesis, See Back Conditions
Spondylosis, See Back Conditions
Spot Baldness, See Alopecia Areata
Spots, See Acne
Stickler Syndrome, See Inherited Disease
Stroke, See Cerebrovascular Disease
Superficial Thrombophlebitis, See Thrombosis
Supraventricular Tachycardia, See Heart, Arrhythmia
Sydenham Chorea, See Rheumatic Fever
T
Tachycardia, See Heart, Arrhythmia
Takayasu Arteritis, See Vasculitis
Tattoo, See Body Piercing
Tay Sachs Disease, See Inherited Disease
Temporal Arteritis, See Vasculitis
Temporal Lobectomy, See Neurosurgery and Epilepsy
Termination Of Pregnancy, See Pregnancy and Surgery
Testosterone Injections, See Hormone Replacement Therapy and Addiction and Drug Abuse
Tetralogy Of Fallot, See Heart, Congenital Defect
Tetraplegia, See Disabled Volunteer
Thalassaemia Major, See Haemoglobin Disorder
Thalassaemia Trait (Minor), See Haemoglobin Disorder
Thrombocythemia, See Thrombocytosis
Thrombophlebitis, See Thrombosis
Thrush, See Candida Infection
Thyrotoxicosis, See Thyroid Disease
Tick Typhus, See Rickettsial Infection
Transient Ischaemic Attack (TIA), See Stroke
Treacher-Collins Syndrome, See Inherited Disease
Trial, See Clinical Trial
Tricuspid Regurgitation, See Heart, Valve Disease
Tricuspid Stenosis, See Heart, Valve Disease
Trypanosoma Cruzi Infection, See South American Trypanosomiasis
U
Ulcerative Colitis, See Inflammatory Bowel Disease
Uterine Fibroid, See Fibroids
Uveitis, See Eye Disease
V
Vaccine, See Immunisation
Vaccination, See Immunisation
Varicella Zoster, See Chicken Pox
Ventricular Septal Defect, See Heart, Congenital Defect
Vestibular Schwannoma, See Acoustic Neuroma
Visceral Leishmaniasis, See Leishmaniasis
Von Recklinghausen Disease, See Neurofibromatosis
Von Willebrand Disease, See Bleeding Disorder
W
Warts, See Human Papilloma Virus
Wegener Granulomatosis, See Vasculitis
Weil Disease, See Leptospirosis
Werdnig-Hoffmann Disease, See Inherited Disease
Wolff-Parkinson-White Syndrome, See Heart, Arrhythmia
X
Y
Yellow Fever, See Infection, Acute
Yellow Fever Vaccine, See Immunisation
Z
Appendix 1 - Haematologic and biochemical testing at donor medical
The following haematological and biochemical tests are performed at the donor medical:
Full blood count
Urea and Electrolytes
Liver function tests
Bone function tests
Cholesterol
Random glucose
Coagulation screen (PT, APTT and fibrinogen)
ABO and Rh blood grouping
Pregnancy test (B-HCG), if relevant
Appendix 2 - Infectious disease marker testing at ET/CT and donor medical
The following infectious disease markers are tested for all donors at the donor medical:
HIV (P24 antigen and antibody)
Hepatitis B (surface antigen and core antibody)
Hepatitis C (antibody and RNA)
HTLV I+II (antibody)
Syphilis (antibody)
Toxoplama (antibody)
EBV (VCA/NA IgG)
CMV (IgG)
Varicella (IgG)
The following infectious disease markers may be tested if a relevant travel history is given by the donor, at the discretion of the harvest physician or Anthony Nolan medical officer:
Malarial antigen/antibodies
T.cruzi (Chagas disease) antibodies
West nile virus NAT
Appendix 3 - Other investigations at donor medical
Electrocardiogram (ECG)
Chest X-ray
Appendix 4 - Special consideration for donors in the Armed Forces
Guidance for Armed Forces donors
It is recognised that members of the Armed Forces will need to get permission from the Commanding Officer prior to donation. Certain occupations within the MOD, such as aircrew within the RAF, will not allow donation by bone marrow harvest unless it is to a family member, although peripheral blood stem cell donation is permitted.
As a consequence, members of the Armed Forces are permitted to join the register as ‘PBSC only’ if there are concerns about the impact of bone marrow harvest on their ability to fulfil their role, or concerns about possible impact on their career.
